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Paper · 200930

Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.

Sugino A and 3 others. Proc Natl Acad Sci U S A, 1977. Cited by 750 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme. Papers, record 200930. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/200930

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
750
iCite
Relative citation ratio, by iCite
18.5
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sugino AA
2Peebles CLC L
3Kreuzer KNK N
4Cozzarelli NRN R

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Bacterial ProteinsMajor topic
DNA ReplicationMajor topic
DNA Topoisomerases, Type IMajor topic
Enzyme InhibitorsMajor topic
Escherichia coliMajor topic
Nalidixic AcidMajor topic
Coliphages
DNA, Superhelical
Molecular Weight
Oxolinic Acid
Protein Biosynthesis
Transduction, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1143,235The mechanism of action of inhibitors of DNA synthesis.Annu Rev Biochem1977https://conductscience.org/library/papers/143235PubMed
2186,775DNA gyrase: an enzyme that introduces superhelical turns into DNA.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/186775PubMed
3138,139A mechanism of duplex DNA replication revealed by enzymatic studies of phage phi X174: catalytic strand separation in advance of replication.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/138139PubMed
4266,716Role of DNA gyrase in phiX replicative-form replication in vitro.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/266716PubMed
5794,878Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/794878PubMed
6792,880Identification and radiochemical purification of the recA protein of Escherichia coli K-12.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/792880PubMed
74,333,036An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay).Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4333036PubMed
84,601,794The identification of late bacteriophage T4 proteins on sodium dodecyl sulfate polyacrylamide gels.Virology1974https://conductscience.org/library/papers/4601794PubMed
94,552,408Prophage lambda at unusual chromosomal locations. I. Location of the secondary attachment sites and the properties of the lysogens.J Mol Biol1972https://conductscience.org/library/papers/4552408PubMed
10172,901Conformational fluctuations of DNA helix.Proc Natl Acad Sci U S A1975https://conductscience.org/library/papers/172901PubMed

1 to 10 of 16

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Cited by353

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 750 citations.

PMIDTitleJournalYearIn PapersSource
42,836,310Adaptation-coupled CRISPRi identifies antibiotic-sensitizing genes leading to a novel plasmid selection marker.Nucleic Acids Res2026https://conductscience.org/library/papers/42836310PubMed
42,509,778A Review of Fluoroquinolones with a Focus on Veterinary-Approved Agents.Biomolecules2026https://conductscience.org/library/papers/42509778PubMed
42,363,830Pyocyanin produced by Pseudomonas aeruginosa creates legacy effects that promote antibiotic resistance evolution in enterococci.Antimicrob Agents Chemother2026https://conductscience.org/library/papers/42363830PubMed
42,242,421Novel Bacterial Topoisomerase Inhibitors: A New Front in an Old War.J Mol Biol2026https://conductscience.org/library/papers/42242421PubMed
41,613,789A Holistic Review of Oncological Drug Targets and Trajectories of Resistance in Cancer Therapy.Oncol Res2026https://conductscience.org/library/papers/41613789PubMed
41,060,329High-content high-resolution microscopy and deep learning-assisted analysis reveals host and bacterial heterogeneity during Shigella infection.Elife2025https://conductscience.org/library/papers/41060329PubMed
40,978,566Electrostatic Loading and Photoredox-Accelerated Release of Antibiotics from Oligoviologen-Crosslinked Hydrogels Using Red Light.Mater Today Chem2024https://conductscience.org/library/papers/40978566PubMed
40,770,476A Comprehensive Review on Discovery, Development, the Chemistry of Quinolones, and Their Antimicrobial Resistance.Curr Top Med Chem2026https://conductscience.org/library/papers/40770476PubMed
40,127,125Structural Mechanisms of Topoisomerase-Targeting Drugs.Annu Rev Biochem2025https://conductscience.org/library/papers/40127125PubMed
39,952,913Nucleotide-induced hyper-oligomerization inactivates transcription termination factor ρ.Nat Commun2025https://conductscience.org/library/papers/39952913PubMed

1 to 10 of 353

See all 353 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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