Paper · 20161830

Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format.

Liu K and 6 others. Curr Chem Genomics, 2008. Cited by 35 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format. Papers, record 20161830. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20161830

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format.; PubMed
Journal: Curr Chem Genomics; PubMed
Year: 2008; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/20161830/; PubMed
DOI: https://doi.org/10.2174/1875397300801010070; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2774619/; PubMed
The journal: https://conductscience.org/library/journal-index/101513465; PubMed
Citations, by iCite: 35; iCite
Relative citation ratio, by iCite: 0.82; iCite
Revised in PubMed: 2025-05-29; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Liu K	Ke
2	Titus S	Steve
3	Southall N	Noel
4	Zhu P	Pingjun
5	Inglese J	James
6	Austin CP	Christopher P
7	Zheng W	Wei

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
Z01 HG200319	Intramural NIH HHS	United States	Z01HG200319	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	16,965,760	D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.	Anal Biochem	2006	https://conductscience.org/library/papers/16965760	PubMed
2	10,081,013	Measurement of [Ca2+] using the Fluorometric Imaging Plate Reader (FLIPR).	Methods Mol Biol	1999	https://conductscience.org/library/papers/10081013	PubMed
3	12,605,869	Scintillation proximity assay of inositol phosphates in cell extracts: high-throughput measurement of G-protein-coupled receptor activation.	Anal Biochem	2003	https://conductscience.org/library/papers/12605869	PubMed
4	16,864,780	Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.	Proc Natl Acad Sci U S A	2006	https://conductscience.org/library/papers/16864780	PubMed
5	16,506,892	Application of cryopreserved cells to HERG screening using a non-radioactive Rb+ efflux assay.	Assay Drug Dev Technol	2006	https://conductscience.org/library/papers/16506892	PubMed
6	15,090,194	High throughput screening technologies for direct cyclic AMP measurement.	Assay Drug Dev Technol	2003	https://conductscience.org/library/papers/15090194	PubMed
7	8,381,210	Inositol trisphosphate and calcium signalling.	Nature	1993	https://conductscience.org/library/papers/8381210	PubMed
8	15,090,209	A 1536-well cAMP assay for Gs- and Gi-coupled receptors using enzyme fragmentation complementation.	Assay Drug Dev Technol	2004	https://conductscience.org/library/papers/15090209	PubMed
9	2,175,603	Muscarinic acetylcholine receptor subtypes which selectively couple to phospholipase C: pharmacological and biochemical properties.	Biochem Biophys Res Commun	1990	https://conductscience.org/library/papers/2175603	PubMed
10	17,637,779	High-throughput screening assays for the identification of chemical probes.	Nat Chem Biol	2007	https://conductscience.org/library/papers/17637779	PubMed

1 to 10 of 23

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Cited by19

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 35 citations.

PMID	Title	Journal	Year	In Papers	Source
41,904,228	A luminescent calcium biosensor enabling endpoint measurement of GPCR-mediated calcium signaling.	Commun Biol	2026	https://conductscience.org/library/papers/41904228	PubMed
40,649,291	Molecular Recognition and Modification Strategies of Umami Dipeptides with T1R1/T1R3 Receptors.	Molecules	2025	https://conductscience.org/library/papers/40649291	PubMed
40,430,029	Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40430029	PubMed
39,395,094	Quantifying Gq Signaling Using the IP1 Homogenous Time-Resolved Fluorescence (HTRF) Assay.	Methods Mol Biol	2025	https://conductscience.org/library/papers/39395094	PubMed
38,385,004	The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models.	Front Behav Neurosci	2024	https://conductscience.org/library/papers/38385004	PubMed
35,850,480	Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity.	SLAS Discov	2022	https://conductscience.org/library/papers/35850480	PubMed
33,659,379	Assessing Gαq/15-signaling with IP-One: Single Plate Transfection and Assay Protocol for Cell-Based High-Throughput Assay.	Bio Protoc	2020	https://conductscience.org/library/papers/33659379	PubMed
33,053,342	PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity.	Cell Rep	2020	https://conductscience.org/library/papers/33053342	PubMed
27,830,715	Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.	Sci Rep	2016	https://conductscience.org/library/papers/27830715	PubMed
27,148,852	The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.	Sci Rep	2016	https://conductscience.org/library/papers/27148852	PubMed

1 to 10 of 19

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Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
AVPR1B	553	PubTator's text mining	https://conductscience.org/library/genes/553	NCBI Gene
CHRM1	1,128	PubTator's text mining	https://conductscience.org/library/genes/1128	NCBI Gene
FFAR1	2,864	PubTator's text mining	https://conductscience.org/library/genes/2864	NCBI Gene
NPSR1	387,129	PubTator's text mining	https://conductscience.org/library/genes/387129	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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