Gene · 1128
CHRM1: cholinergic receptor muscarinic 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CHRM1: cholinergic receptor muscarinic 1. Genes, record 1128. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1128
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P11229 | Muscarinic acetylcholine receptor M1 | 460 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents61
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026062654 A | 2026-04-10 | 39 | P11229 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 41208 | P11229 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 926 | P11229 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 926 | P11229 | Espacenet |
| US 12298319 B2 | 2025-05-13 | 2 | P11229 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 26355 | P11229 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 26355 | P11229 | Espacenet |
| JP 2023156353 A | 2023-10-24 | 39 | P11229 | Espacenet |
| JP 2023153821 A | 2023-10-18 | 11 | P11229 | Espacenet |
| JP 2023089681 A | 2023-06-28 | 5 | P11229 | Espacenet |
1 to 10 of 61
See all 61 patentsDrugs68
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AFACIFENACIN | CHEMBL3545165 | Muscarinic acetylcholine receptor antagonist | ANTAGONIST | ChEMBL |
| ANISOTROPINE | CHEMBL1186610 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| ANISOTROPINE METHYLBROMIDE | CHEMBL1578 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| ASM-024 | CHEMBL3707249 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| ATROPINE | CHEMBL517712 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| ATROPINE SULFATE | CHEMBL2146146 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| BENZTROPINE | CHEMBL1201203 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| BENZTROPINE MESYLATE | CHEMBL1200383 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| BIPERIDEN | CHEMBL1101 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
| BIPERIDEN HYDROCHLORIDE | CHEMBL1201035 | Muscarinic acetylcholine receptor M1 antagonist | ANTAGONIST | ChEMBL |
1 to 10 of 68
See all 68 drugsTrials397
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07595796 | GLYCOPYRRONIUM BROMIDE | ClinicalTrials.gov | ||
| NCT07571148 | XANOMELINE | ClinicalTrials.gov | ||
| NCT07546981 | GLYCOPYRRONIUM BROMIDE | PHASE3 | ClinicalTrials.gov | |
| NCT07541378 | GLYCOPYRRONIUM | ClinicalTrials.gov | ||
| NCT07537166 | ATROPINE | ClinicalTrials.gov | ||
| NCT07525375 | GLYCOPYRRONIUM | PHASE2 | ClinicalTrials.gov | |
| NCT07494799 | ATROPINE | ClinicalTrials.gov | ||
| NCT07489911 | GLYCOPYRRONIUM | ClinicalTrials.gov | ||
| NCT07456488 | ATROPINE | PHASE2 | ClinicalTrials.gov | |
| NCT07424404 | XANOMELINE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 397
See all 397 trialsNIH grants995
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CHRM1 papers | Newest fiscal year |
|---|---|---|---|
| P30DA018343 | Yale/NIDA Neuroproteomics Center | 7 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 5 | 2025 |
| T32MH065215 | Postdoctoral Program in Functional Neurogenomics | 4 | 2025 |
| P01HL114501 | Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers | 3 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 3 | 2025 |
| R01NS031373 | Functions of Metabotropic Glutamate Receptor Subtypes | 3 | 2025 |
| R35GM122481 | Development and Testing of New Computational Methods for Ligand Discovery and Mechanism | 3 | 2025 |
| R37CA242006 | Defining the Role of Tumor-Neutral Crosstalk in head and Neck Cancer Progression and Treatment Resistance | 3 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
1 to 10 of 995Source NIH's project files
See all 995 nih grantsPapers1,761
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Short-term outcomes of a refined duodenal LECS technique: A single-center retrospective series. | Surg Oncol | 2026 | 42815342 | PubTator, text mining | PubMed |
| Structural basis for broad orthopoxvirus neutralization by two antibodies targeting distinct L1R epitopes. | Cell Rep Med | 2026 | 42805179 | PubTator, text mining | PubMed |
| GPCR-Driven Muscarinic M1 and Histamine H1 Receptor Signaling Converging on the PI3K/Akt/mTOR Pathway: Functional Integration in Neuroinflammation and Myelin Repair in Multiple Sclerosis. | Mol Neurobiol | 2026 | 42714765 | PubTator, text mining | PubMed |
| From human dental pulp stem cells to functional cholinergic neurons: An optimized neurogenic differentiation protocol for new approach methodologies. | J Dent Sci | 2026 | 42688638 | PubTator, text mining | PubMed |
| Machine learning-assisted design of a dendritic cell nanovaccine inducing twin immunity against monkeypox. | J Control Release | 2026 | 42660460 | PubTator, text mining | PubMed |
| TDP-43 promotes allergen-induced inflammation and influenza A virus replication in airway epithelium. | Nat Commun | 2026 | 42642428 | PubTator, text mining | PubMed |
| Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi-Stage Computational Analysis. | J Comput Chem | 2026 | 42530159 | PubTator, text mining | PubMed |
| Functional insights into autoantibodies targeting muscarinic acetylcholine receptors in Sjögren's disease. | Ann Rheum Dis | 2026 | 42425798 | PubTator, text mining | PubMed |
| An integrated review of monkeypox: from pathogen and epidemiology to diagnostics, control, and challenges. | Emerg Microbes Infect | 2026 | 42410978 | PubTator, text mining | PubMed |
| Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects. | ACS Chem Neurosci | 2026 | 42376914 | PubTator, text mining | PubMed |
1 to 10 of 1,761
See all 1,761 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1128
GET https://conductscience.org/api/genes/v1/1128/patents?page=2