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Gene · 1128

CHRM1: cholinergic receptor muscarinic 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRM1: cholinergic receptor muscarinic 1. Genes, record 1128. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1128

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Gene

Symbol
CHRM1
HGNC
Name
cholinergic receptor muscarinic 1
HGNC
NCBI Gene ID
1128
NCBI Gene
HGNC ID
HGNC:1950
HGNC
Ensembl
ENSG00000168539
NCBI Gene
Aliases
HM1, M1, M1R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P11229Muscarinic acetylcholine receptor M14607Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1039P11229Espacenet
JP 2026004568 A2026-01-1441208P11229Espacenet
JP 2025529142 A2025-09-04926P11229Espacenet
US 12371689 B22025-07-29926P11229Espacenet
US 12298319 B22025-05-132P11229Espacenet
JP 2025032204 A2025-03-1126355P11229Espacenet
EP 4461818 A22024-11-1326355P11229Espacenet
JP 2023156353 A2023-10-2439P11229Espacenet
JP 2023153821 A2023-10-1811P11229Espacenet
JP 2023089681 A2023-06-285P11229Espacenet

1 to 10 of 61

See all 61 patents

Drugs68

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFACIFENACINCHEMBL3545165Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
ANISOTROPINECHEMBL1186610Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
ANISOTROPINE METHYLBROMIDECHEMBL1578Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
ASM-024CHEMBL3707249Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
ATROPINECHEMBL517712Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
ATROPINE SULFATECHEMBL2146146Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
BENZTROPINECHEMBL1201203Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
BENZTROPINE MESYLATECHEMBL1200383Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
BIPERIDENCHEMBL1101Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL
BIPERIDEN HYDROCHLORIDECHEMBL1201035Muscarinic acetylcholine receptor M1 antagonistANTAGONISTChEMBL

1 to 10 of 68

See all 68 drugs

Trials397

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07595796GLYCOPYRRONIUM BROMIDEClinicalTrials.gov
NCT07571148XANOMELINEClinicalTrials.gov
NCT07546981GLYCOPYRRONIUM BROMIDEPHASE3ClinicalTrials.gov
NCT07541378GLYCOPYRRONIUMClinicalTrials.gov
NCT07537166ATROPINEClinicalTrials.gov
NCT07525375GLYCOPYRRONIUMPHASE2ClinicalTrials.gov
NCT07494799ATROPINEClinicalTrials.gov
NCT07489911GLYCOPYRRONIUMClinicalTrials.gov
NCT07456488ATROPINEPHASE2ClinicalTrials.gov
NCT07424404XANOMELINEPHASE3ClinicalTrials.gov

1 to 10 of 397

See all 397 trials

NIH grants995

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRM1 papersNewest fiscal year
P30DA018343Yale/NIDA Neuroproteomics Center72025
P30DK045735Yale Diabetes Research Center52025
T32MH065215Postdoctoral Program in Functional Neurogenomics42025
P01HL114501Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers32025
P30CA045508CSHL Cancer Center Support Grant32025
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes32025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism32025
R37CA242006Defining the Role of Tumor-Neutral Crosstalk in head and Neck Cancer Progression and Treatment Resistance32025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)32025
UL1TR001863Yale Clinical and Translational Science Award32025

1 to 10 of 995Source NIH's project files

See all 995 nih grants

Papers1,761

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Short-term outcomes of a refined duodenal LECS technique: A single-center retrospective series.Surg Oncol202642815342PubTator, text miningPubMed
Structural basis for broad orthopoxvirus neutralization by two antibodies targeting distinct L1R epitopes.Cell Rep Med202642805179PubTator, text miningPubMed
GPCR-Driven Muscarinic M1 and Histamine H1 Receptor Signaling Converging on the PI3K/Akt/mTOR Pathway: Functional Integration in Neuroinflammation and Myelin Repair in Multiple Sclerosis.Mol Neurobiol202642714765PubTator, text miningPubMed
From human dental pulp stem cells to functional cholinergic neurons: An optimized neurogenic differentiation protocol for new approach methodologies.J Dent Sci202642688638PubTator, text miningPubMed
Machine learning-assisted design of a dendritic cell nanovaccine inducing twin immunity against monkeypox.J Control Release202642660460PubTator, text miningPubMed
TDP-43 promotes allergen-induced inflammation and influenza A virus replication in airway epithelium.Nat Commun202642642428PubTator, text miningPubMed
Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi-Stage Computational Analysis.J Comput Chem202642530159PubTator, text miningPubMed
Functional insights into autoantibodies targeting muscarinic acetylcholine receptors in Sjögren's disease.Ann Rheum Dis202642425798PubTator, text miningPubMed
An integrated review of monkeypox: from pathogen and epidemiology to diagnostics, control, and challenges.Emerg Microbes Infect202642410978PubTator, text miningPubMed
Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.ACS Chem Neurosci202642376914PubTator, text miningPubMed

1 to 10 of 1,761

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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