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Paper · 20182602

TP53 mutations in human cancers: origins, consequences, and clinical use.

Olivier M and 2 others. Cold Spring Harb Perspect Biol, 2010. Cited by 1,650 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. TP53 mutations in human cancers: origins, consequences, and clinical use. Papers, record 20182602. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20182602

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
TP53 mutations in human cancers: origins, consequences, and clinical use.
PubMed
Journal
Cold Spring Harb Perspect Biol
PubMed
Year
2010
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
1,650
iCite
Relative citation ratio, by iCite
37.6
iCite
Revised in PubMed
2022-04-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Olivier MMagali
2Hollstein MMonica
3Hainaut PPierre

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gene Expression Regulation, NeoplasticMajor topic
Genes, p53Major topic
MutationMajor topic
NeoplasmsMajor topic
Animals
Carcinogens
CpG Islands
Humans
Mice
Mice, Transgenic
Models, Biological
Mutagenesis
Prognosis

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References107

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
120,182,618Mutant p53 gain-of-function in cancer.Cold Spring Harb Perspect Biol2010https://conductscience.org/library/papers/20182618PubMed
215,055,300TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer.IARC Sci Publ2004https://conductscience.org/library/papers/15055300PubMed
31,458,490A functional screen for germ line p53 mutations based on transcriptional activation.Cancer Res1992https://conductscience.org/library/papers/1458490PubMed
41,978,757Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.Science1990https://conductscience.org/library/papers/1978757PubMed
516,777,987MEF immortalization to investigate the ins and outs of mutagenesis.Carcinogenesis2006https://conductscience.org/library/papers/16777987PubMed
617,401,432Structure-function-rescue: the diverse nature of common p53 cancer mutants.Oncogene2007https://conductscience.org/library/papers/17401432PubMed
710,802,655A common polymorphism acts as an intragenic modifier of mutant p53 behaviour.Nat Genet2000https://conductscience.org/library/papers/10802655PubMed
817,344,846Patterns of somatic mutation in human cancer genomes.Nature2007https://conductscience.org/library/papers/17344846PubMed
91,546,979Methylation, mutation and cancer.Bioessays1992https://conductscience.org/library/papers/1546979PubMed
1011,313,961Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.Oncogene2001https://conductscience.org/library/papers/11313961PubMed

1 to 10 of 107

See all 107 references

Cited by1,217

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,650 citations.

PMIDTitleJournalYearIn PapersSource
42,961,508TP53 dysregulation in Wilms tumor: an integrative clinico-genomic analysis and its prognostic implications.Mol Genet Genomics2026https://conductscience.org/library/papers/42961508PubMed
42,958,183Machine learning-guided identification of determinants of PD-L1 expression and tumor mutational burden in lung squamous cell carcinoma.BMC Pulm Med2026https://conductscience.org/library/papers/42958183PubMed
42,928,139Characterisation of a novel p53 mutation (p53N263Tfs*7) associated with li-fraumeni syndrome.BMC Cancer2026https://conductscience.org/library/papers/42928139PubMed
42,911,976Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns based upon clinico-genomic status.PLoS Genet2026https://conductscience.org/library/papers/42911976PubMed
42,909,883Exon-6 truncated p53 Suppresses Innate Immune Responses to Facilitate Immune Evasion in Bladder Cancer.Int J Biol Sci2026https://conductscience.org/library/papers/42909883PubMed
42,891,904Association of TP53 Truncating Mutations with Time to Treatment Failure after First-Line Chemoimmunotherapy in HER2-Mutant Non-Small Cell Lung Cancer.Target Oncol2026https://conductscience.org/library/papers/42891904PubMed
42,877,144Shikonin treatment ameliorates lipopolysaccharide-induced acute liver failure in mice via regulating miR-106/MCL1 and miR-34a/SIRT1/TP53 signaling.Arch Med Sci2026https://conductscience.org/library/papers/42877144PubMed
42,860,857UPLC-Q-TOF-MS/MS Profiling and Synergistic Anti-HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC-MSC-Exos.Chem Biodivers2026https://conductscience.org/library/papers/42860857PubMed
42,840,663The Amyloid State of Mutant p53 in Cancer.JMA J2026https://conductscience.org/library/papers/42840663PubMed
42,839,920Real world genomic profiling in non-small cell lung cancer reveals regional variations with clinical implications.Front Oncol2026https://conductscience.org/library/papers/42839920PubMed

1 to 10 of 1,217

See all 1,217 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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