Paper · 2137462

Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.

Alcover A and 3 others. J Biol Chem, 1990. Cited by 85 papers, by iCite.

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ConductScience Library. Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization. Papers, record 2137462. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2137462

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.; PubMed
Journal: J Biol Chem; PubMed
Year: 1990; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2137462/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 85; iCite
Relative citation ratio, by iCite: 1.25; iCite
Revised in PubMed: 2021-02-10; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Alcover A	A
2	Mariuzza RA	R A
3	Ermonval M	M
4	Acuto O	O

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens, CD	Major topic
Antigens, Differentiation, T-Lymphocyte	Major topic
Lysine	Major topic
Receptors, Antigen, T-Cell	Major topic
Base Sequence
CD3 Complex
Cell Membrane
Cloning, Molecular
Genes
Humans
Macromolecular Substances
Membrane Glycoproteins
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Restriction Mapping
T-Lymphocytes
Transfection

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

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None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by34

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 85 citations.

PMID	Title	Journal	Year	In Papers	Source
41,865,294	Membrane-Based Assembly and Interactions in Immune Receptors.	Chem Rev	2026	https://conductscience.org/library/papers/41865294	PubMed
39,745,432	Biophysical and Structural Features of αβT-Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T-Cell Activation.	Immunol Rev	2025	https://conductscience.org/library/papers/39745432	PubMed
34,260,912	Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation.	Cell Rep	2021	https://conductscience.org/library/papers/34260912	PubMed
30,877,195	Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues.	J Biol Chem	2019	https://conductscience.org/library/papers/30877195	PubMed
30,815,789	NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology.	J Biomol NMR	2019	https://conductscience.org/library/papers/30815789	PubMed
30,389,415	The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.	Immunity	2018	https://conductscience.org/library/papers/30389415	PubMed
25,947,381	Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION.	J Biol Chem	2015	https://conductscience.org/library/papers/25947381	PubMed
24,488,493	Structure of the chicken CD3εδ/γ heterodimer and its assembly with the αβT cell receptor.	J Biol Chem	2014	https://conductscience.org/library/papers/24488493	PubMed
24,454,946	Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells.	PLoS One	2014	https://conductscience.org/library/papers/24454946	PubMed
23,133,531	Diversity, molecular characterization and expression of T cell receptor γ in a teleost fish, the sea bass (Dicentrarchus labrax, L).	PLoS One	2012	https://conductscience.org/library/papers/23133531	PubMed

1 to 10 of 34

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
APP	351	PubTator's text mining	https://conductscience.org/library/genes/351	NCBI Gene
EDNRA	1,909	PubTator's text mining	https://conductscience.org/library/genes/1909	NCBI Gene
TRB	6,957	PubTator's text mining	https://conductscience.org/library/genes/6957	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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