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Paper21390191

Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.

Kim SJ and 14 others. Neoplasia, 2011. Cited by 226 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Papers, record 21390191. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21390191

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
PubMed
Journal
Neoplasia
PubMed
Year
2011
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
226
iCite
Relative citation ratio, by iCite
5.25
iCite
Revised in PubMed
2022-02-24
PubMed

Authors15

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kim SJSun-Jin
2Kim JSJang-Seong
3Park ESEun Sung
4Lee JSJu-Seog
5Lin QQingtang
6Langley RRRobert R
7Maya MMarva
8He JJunqin
9Kim SWSeung-Wook
10Weihua ZZhang
11Balasubramanian KKrishnakumar
12Fan DDominic
13Mills GBGordon B
14Hung MCMien-Chie
15Fidler IJIsaiah J

Source PubMed

Topics27

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antineoplastic AgentsMajor topic
AstrocytesMajor topic
Biomarkers, TumorMajor topic
Brain NeoplasmsMajor topic
Breast NeoplasmsMajor topic
Drug Resistance, NeoplasmMajor topic
Lung NeoplasmsMajor topic
Adenocarcinoma
Animals
Apoptosis
Blotting, Western
Cell Proliferation
Cells, Cultured
Fibroblasts
Gene Expression Profiling
Glutathione Transferase
Humans
Isoenzymes
Mice
Mice, Nude
Nuclear Proteins
Oligonucleotide Array Sequence Analysis
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Twist-Related Protein 1
Up-Regulation
bcl-X Protein

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 CA016672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
1U54CA143834-01NCI NIH HHSUnited StatesU54CA143834PubMedNIH RePORTER
CA16672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
P01 CA099031NCI NIH HHSUnited StatesP01CA099031PubMed and NIHNIH RePORTER
P50 CA098258NCI NIH HHSUnited StatesP50CA098258PubMed and NIHNIH RePORTER
CA99031NCI NIH HHSUnited StatesP01CA099031PubMed and NIHNIH RePORTER
P30CA016672NIHNIH RePORTER

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
119,005,240Astrocyte, the star avatar: redefined.J Biosci2008https://conductscience.org/library/papers/19005240PubMed
215,846,805Astrocyte activation and reactive gliosis.Glia2005https://conductscience.org/library/papers/15846805PubMed
38,688,151Gap-junction disassembly and connexin 43 dephosphorylation induced by 18 beta-glycyrrhetinic acid.Mol Carcinog1996https://conductscience.org/library/papers/8688151PubMed
419,332,720Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.J Clin Oncol2009https://conductscience.org/library/papers/19332720PubMed
516,151,042Reactive astrocytes in neural repair and protection.Neuroscientist2005https://conductscience.org/library/papers/16151042PubMed
618,432,251Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival.Nat Rev Cancer2008https://conductscience.org/library/papers/18432251PubMed
78,549,672Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative.Exp Cell Res1996https://conductscience.org/library/papers/8549672PubMed
817,504,269Glutamate-mediated neuronal-glial transmission.J Anat2007https://conductscience.org/library/papers/17504269PubMed
917,965,657Glial regulation of the cerebral microvasculature.Nat Neurosci2007https://conductscience.org/library/papers/17965657PubMed
1012,448,698Gap junctions as targets for cancer chemoprevention and chemotherapy.Curr Drug Targets2002https://conductscience.org/library/papers/12448698PubMed
1112,538,238A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.Bioinformatics2003https://conductscience.org/library/papers/12538238PubMed
1216,280,676Brain metastases.Curr Opin Neurol2005https://conductscience.org/library/papers/16280676PubMed
131,974,900Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.J Histochem Cytochem1990https://conductscience.org/library/papers/1974900PubMed
1420,824,051Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels.Neoplasia2010https://conductscience.org/library/papers/20824051PubMed
1515,172,974Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells.Cancer Res2004https://conductscience.org/library/papers/15172974PubMed
1617,538,177Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm.J Clin Oncol2007https://conductscience.org/library/papers/17538177PubMed
1712,162,730Astrocyte-endothelial interactions and blood-brain barrier permeability.J Anat2002https://conductscience.org/library/papers/12162730PubMed
1812,076,520Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes.Chem Biol Interact2002https://conductscience.org/library/papers/12076520PubMed
198,134,839Direct signaling from astrocytes to neurons in cultures of mammalian brain cells.Science1994https://conductscience.org/library/papers/8134839PubMed
203,961,495A fluorescence photobleaching assay of gap junction-mediated communication between human cells.Science1986https://conductscience.org/library/papers/3961495PubMed

See all 49 references

Cited by161

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 226 citations.

PMIDTitleJournalYearIn PapersSource
42,908,732Breast cancer brain metastasis: mechanisms, emerging biomarkers, and therapeutic opportunities.Am J Cancer Res2026https://conductscience.org/library/papers/42908732PubMed
42,026,142Astrocyte-driven immunosuppression in the brain tumor microenvironment.Nat Immunol2026https://conductscience.org/library/papers/42026142PubMed
41,972,151Breast cancer brain metastasis: from molecular insights to therapeutic innovation.Front Immunol2026https://conductscience.org/library/papers/41972151PubMed
41,613,141B cell immunity and therapeutic opportunities in brain metastases.Front Immunol2025https://conductscience.org/library/papers/41613141PubMed
41,497,454Brain metastasis patient-derived xenograft models to characterize the contribution of brain microenvironment to metastatic outgrowth.Neurooncol Adv2025https://conductscience.org/library/papers/41497454PubMed
41,411,048MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype.J Clin Invest2026https://conductscience.org/library/papers/41411048PubMed
41,331,608Astrocyte Reprogramming Drives Tumor Progression and Chemotherapy Resistance in Agent-Based Models of Breast Cancer Brain Metastases.Bull Math Biol2025https://conductscience.org/library/papers/41331608PubMed
40,960,488Spatial Cross-talk Modeling of the Tumor Microenvironment Identifies CCR5-Mediated Glia-to-Glia Signaling as a Key Regulator of Brain Metastatic Progression.Cancer Res2025https://conductscience.org/library/papers/40960488PubMed
40,664,897Astrocyte involvement in brain metastasis: from biological mechanisms to therapeutic strategies.Cancer Metastasis Rev2025https://conductscience.org/library/papers/40664897PubMed
40,253,355Biological profile of breast cancer brain metastasis.Acta Neuropathol Commun2025https://conductscience.org/library/papers/40253355PubMed
40,149,331Effects of Induced Pluripotent Stem Cell-Derived Astrocytes on Cisplatin Sensitivity in Pediatric Brain Cancer Cells.Cancers (Basel)2025https://conductscience.org/library/papers/40149331PubMed
39,238,191Analysis of neuroglia and immune cells in the tumor microenvironment of breast cancer brain metastasis.Cancer Biol Ther2024https://conductscience.org/library/papers/39238191PubMed
39,175,471Crosstalk between breast cancer-derived microRNAs and brain microenvironmental cells in breast cancer brain metastasis.Front Oncol2024https://conductscience.org/library/papers/39175471PubMed
37,792,172Understanding crosstalk of organ tropism, tumor microenvironment and noncoding RNAs in breast cancer metastasis.Mol Biol Rep2023https://conductscience.org/library/papers/37792172PubMed
37,783,795Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis.Nat Cell Biol2023https://conductscience.org/library/papers/37783795PubMed
37,749,707Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development.Acta Neuropathol Commun2023https://conductscience.org/library/papers/37749707PubMed
37,491,527Leveraging translational insights toward precision medicine approaches for brain metastases.Nat Cancer2023https://conductscience.org/library/papers/37491527PubMed
37,454,033A novel cross-communication of HIF-1α and HIF-2α with Wnt signaling in TNBC and influence of hypoxic microenvironment in the formation of an organ-on-chip model of breast cancer.Med Oncol2023https://conductscience.org/library/papers/37454033PubMed
37,386,445Breast cancer brain metastasis: from etiology to state-of-the-art modeling.J Biol Eng2023https://conductscience.org/library/papers/37386445PubMed
37,345,193Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas.Cancers (Basel)2023https://conductscience.org/library/papers/37345193PubMed

See all 161 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BCL2L1598PubTator's text mininghttps://conductscience.org/library/genes/598NCBI Gene
GSTA5221,357PubTator's text mininghttps://conductscience.org/library/genes/221357NCBI Gene
TWIST17,291PubTator's text mininghttps://conductscience.org/library/genes/7291NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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