Paper · 2236070

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

Sugawa N and 3 others. Proc Natl Acad Sci U S A, 1990. Cited by 514 papers, by iCite.

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ConductScience Library. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Papers, record 2236070. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2236070

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1990; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2236070/; PubMed
DOI: https://doi.org/10.1073/pnas.87.21.8602; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC55005/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 514; iCite
Relative citation ratio, by iCite: 10; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Sugawa N	N
2	Ekstrand AJ	A J
3	James CD	C D
4	Collins VP	V P

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
ErbB Receptors	Major topic
Gene Rearrangement	Major topic
Glioma	Major topic
RNA Splicing	Major topic
Transcription, Genetic	Major topic
Amino Acid Sequence
Base Sequence
Blotting, Northern
DNA, Neoplasm
Exons
Humans
Introns
Molecular Sequence Data
Polymerase Chain Reaction

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record
NCT03058198	The Research on 89Zr-ABT806 PET Imaging in High Grade Glioma	Background

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,691,502	Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor.	Proc Natl Acad Sci U S A	1990	https://conductscience.org/library/papers/1691502	PubMed
2	2,294,591	Identification of a chromosome 18q gene that is altered in colorectal cancers.	Science	1990	https://conductscience.org/library/papers/2294591	PubMed
3	2,168,866	A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors.	Jpn J Cancer Res	1990	https://conductscience.org/library/papers/2168866	PubMed
4	6,318,976	Expression of epidermal growth factor receptors in human brain tumors.	Cancer Res	1984	https://conductscience.org/library/papers/6318976	PubMed
5	6,326,261	Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.	Science	1984	https://conductscience.org/library/papers/6326261	PubMed
6	6,328,312	Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.	Nature	1984	https://conductscience.org/library/papers/6328312	PubMed
7	6,086,719	Human squamous cell lung cancers express increased epidermal growth factor receptors.	J Clin Invest	1984	https://conductscience.org/library/papers/6086719	PubMed
8	6,090,945	Autophosphorylation sites on the epidermal growth factor receptor.	Nature	1984	https://conductscience.org/library/papers/6090945	PubMed
9	6,095,284	Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6095284	PubMed
10	2,981,413	Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.	Nature	1985	https://conductscience.org/library/papers/2981413	PubMed

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Cited by260

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 514 citations.

PMID	Title	Journal	Year	In Papers	Source
42,545,507	Improving T-cell engager efficacy in glioblastoma with multi-antigen targeting and novel delivery approaches.	Acta Neuropathol	2026	https://conductscience.org/library/papers/42545507	PubMed
42,041,891	Adoptive Cell Therapies for Glioblastoma: A Quest for Cures from Within.	Biology (Basel)	2026	https://conductscience.org/library/papers/42041891	PubMed
40,933,038	Immunologic specificity in glioblastoma: Antigen discovery and translational implications.	Neurooncol Adv	2025	https://conductscience.org/library/papers/40933038	PubMed
40,661,781	Vaccine therapies for glioma: clinical frontiers and potential breakthrough.	Front Oncol	2025	https://conductscience.org/library/papers/40661781	PubMed
40,362,634	A Positive Feedback DNA-PK/MYT1L-CXCR1-ERK1/2 Proliferative Signaling Loop in Glioblastoma.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40362634	PubMed
39,827,297	Presence of EGF ligand restricts the binding ability of EgB4 nanobody to EGFR extracellular domain.	Sci Rep	2025	https://conductscience.org/library/papers/39827297	PubMed
39,408,897	Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma.	Int J Mol Sci	2024	https://conductscience.org/library/papers/39408897	PubMed
39,334,963	Enhanced Anticancer Activity of 7MeERT over Ertredin: A Comparative Study on Cancer Cell Proliferation and NDUFA12 Binding.	Biomolecules	2024	https://conductscience.org/library/papers/39334963	PubMed
39,292,778	Development of an antigen-based approach to noninvasively image CAR T cells in real time and as a predictive tool.	Sci Adv	2024	https://conductscience.org/library/papers/39292778	PubMed
39,231,832	Interleukin 6 and cancer resistance in glioblastoma multiforme.	Neurosurg Rev	2024	https://conductscience.org/library/papers/39231832	PubMed

1 to 10 of 260

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
EGFR	1,956	PubTator's text mining	https://conductscience.org/library/genes/1956

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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