ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 23965987

Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.

Strohecker AM and 7 others. Cancer Discov, 2013. Cited by 369 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Papers, record 23965987. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23965987

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.
PubMed
Journal
Cancer Discov
PubMed
Year
2013
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
369
iCite
Relative citation ratio, by iCite
9.35
iCite
Revised in PubMed
2022-03-11
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Strohecker AMAnne M
2Guo JYJessie Yanxiang
3Karsli-Uzunbas GGizem
4Price SMSandy M
5Chen GJGuanghua Jim
6Mathew RRobin
7McMahon MMartin
8White EEileen

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AutophagyMajor topic
GlutamineMajor topic
Lung NeoplasmsMajor topic
Microtubule-Associated ProteinsMajor topic
MitochondriaMajor topic
Proto-Oncogene Proteins B-rafMajor topic
Adenocarcinoma
Adenoma
Adenoma, Oxyphilic
Animals
Autophagy-Related Protein 7
Cell Line, Tumor
Cell Transformation, Neoplastic
Disease Models, Animal
Gene Deletion
Gene Expression Regulation, Neoplastic
Humans
Mice
NF-E2-Related Factor 2
Oxidative Stress
Tumor Suppressor Protein p53

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 CA131261NCI NIH HHSUnited StatesR01CA131261PubMed and NIHNIH RePORTER
R37 CA53370NCI NIH HHSUnited StatesR37CA053370PubMed and NIHNIH RePORTER
R01 CA163591NCI NIH HHSUnited StatesR01CA163591PubMed and NIHNIH RePORTER
R37 CA053370NCI NIH HHSUnited StatesR37CA053370PubMed and NIHNIH RePORTER
R01 CA130893NCI NIH HHSUnited StatesR01CA130893PubMed and NIHNIH RePORTER
RC1 CA147961NCI NIH HHSUnited StatesRC1CA147961PubMed and NIHNIH RePORTER
P30 CA072720NCI NIH HHSUnited StatesP30CA072720PubMed and NIHNIH RePORTER
RCI CA147961NCI NIH HHSUnited StatesRC1CA147961PubMed and NIHNIH RePORTER
CA131261NCI NIH HHSUnited StatesR01CA131261PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in24,203,955Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer.https://conductscience.org/library/papers/24203955

Source PubMed

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,224,160Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.FEBS Lett1993https://conductscience.org/library/papers/8224160PubMed
220,173,742The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.Nat Cell Biol2010https://conductscience.org/library/papers/20173742PubMed
317,510,285Autophagy suppresses tumor progression by limiting chromosomal instability.Genes Dev2007https://conductscience.org/library/papers/17510285PubMed
423,650,262Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.Cancer Discov2013https://conductscience.org/library/papers/23650262PubMed
521,498,569Autophagy-deficient mice develop multiple liver tumors.Genes Dev2011https://conductscience.org/library/papers/21498569PubMed
621,764,854Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis.Genes Dev2011https://conductscience.org/library/papers/21764854PubMed
717,299,132A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors.Genes Dev2007https://conductscience.org/library/papers/17299132PubMed
814,657,337Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.Proc Natl Acad Sci U S A2003https://conductscience.org/library/papers/14657337PubMed
921,248,763KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma.J Hum Genet2011https://conductscience.org/library/papers/21248763PubMed
1022,534,666Deconvoluting the context-dependent role for autophagy in cancer.Nat Rev Cancer2012https://conductscience.org/library/papers/22534666PubMed

1 to 10 of 36

See all 36 references

Cited by278

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 369 citations.

PMIDTitleJournalYearIn PapersSource
42,929,236NLRC4 Acts as a Non-Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy.J Cell Mol Med2026https://conductscience.org/library/papers/42929236PubMed
42,845,528Myeloid differentiation-associated autophagy drives venetoclax resistance in AML.Res Sq2026https://conductscience.org/library/papers/42845528PubMed
42,642,776Unraveling the role of glutamine metabolism in cancer: from cell death mechanisms to tumor microenvironment modulation.Exp Hematol Oncol2026https://conductscience.org/library/papers/42642776PubMed
42,544,547Practical management of BRAF inhibitors in glioma: toxicity and resistance.CNS Oncol2026https://conductscience.org/library/papers/42544547PubMed
42,236,674Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42236674PubMed
42,151,413Autophagy modulation in cancer.Nat Rev Drug Discov2026https://conductscience.org/library/papers/42151413PubMed
41,792,9991,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy.Mol Ther2026https://conductscience.org/library/papers/41792999PubMed
41,663,197Current Perspectives on Pediatric Low-Grade Gliomas: Focus on BRAF and MEK Inhibition.Brain Tumor Res Treat2026https://conductscience.org/library/papers/41663197PubMed
41,637,269Quantitative and temporal analysis of autophagy: Differential Response to amino acid and glucose starvation.PLoS One2026https://conductscience.org/library/papers/41637269PubMed
41,402,797Amino acids metabolism: a potential target for cancer treatment.Mol Cancer2025https://conductscience.org/library/papers/41402797PubMed

1 to 10 of 278

See all 278 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/23965987

GET https://conductscience.org/api/papers/v1/23965987/references?page=2

API referenceFor AI assistants