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Paper · 24009397

Gut microbiota from twins discordant for obesity modulate metabolism in mice.

Ridaura VK and 24 others. Science, 2013. Cited by 2,852 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Papers, record 24009397. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24009397

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Gut microbiota from twins discordant for obesity modulate metabolism in mice.
PubMed
Journal
Science
PubMed
Year
2013
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Twin Study
PubMed
Citations, by iCite
2,852
iCite
Relative citation ratio, by iCite
94.1
iCite
Revised in PubMed
2022-04-15
PubMed

Authors25

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ridaura VKVanessa K
2Faith JJJeremiah J
3Rey FEFederico E
4Cheng JJiye
5Duncan AEAlexis E
6Kau ALAndrew L
7Griffin NWNicholas W
8Lombard VVincent
9Henrissat BBernard
10Bain JRJames R

1 to 10 of 25Source PubMed

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Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AdiposityMajor topic
BacteroidetesMajor topic
Gastrointestinal TractMajor topic
MetagenomeMajor topic
ObesityMajor topic
Adult
Animals
Cecum
Diet, Fat-Restricted
Feces
Female
Germ-Free Life
Humans
Metabolome
Mice
Mice, Inbred C57BL
Mice, Obese
Thinness
Twins
Weight Gain
Young Adult

Source PubMed

Grants17

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
K01 DK095774NIDDK NIH HHSUnited StatesK01DK095774PubMed and NIHNIH RePORTER
K05 AA017688NIAAA NIH HHSUnited StatesK05AA017688PubMed and NIHNIH RePORTER
Howard Hughes Medical InstituteUnited StatesPubMedPubMed
P30-AG028716NIA NIH HHSUnited StatesP30AG028716PubMed and NIHNIH RePORTER
DK078669NIDDK NIH HHSUnited StatesP01DK078669PubMed and NIHNIH RePORTER
R01 DK076729NIDDK NIH HHSUnited StatesR01DK076729PubMed and NIHNIH RePORTER
DK70977NIDDK NIH HHSUnited StatesR01DK070977PubMed and NIHNIH RePORTER
T32 GM142607NIGMS NIH HHSUnited StatesT32GM142607PubMedNIH RePORTER
F32 DK091044NIDDK NIH HHSUnited StatesF32DK091044PubMed and NIHNIH RePORTER
P01 DK078669NIDDK NIH HHSUnited StatesP01DK078669PubMed and NIHNIH RePORTER

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Trials5

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT03078283Food Effects on the Gut MicrobiotaBackgroundClinicalTrials.gov
NCT03127696Randomised Placebo-controlled Study of FMT to Impact Body Weight and Glycemic Control in Obese Subjects With T2DMBackgroundClinicalTrials.gov
NCT03232099Red Wine Effects Upon Gut Flora and Plasma Levels of Trimethylamine-N-oxide (TMAO) - WineFlora StudyBackgroundClinicalTrials.gov
NCT03789461Fecal Microbiota Transplant (FMT) to Induce Weight Loss in Obese SubjectsBackgroundClinicalTrials.gov
NCT05869799Effect of Vigiis 101 Lactic Acid Bacteria Powder on Body Weight and Body Fat in Overweight ParticipantsResultsClinicalTrials.gov

Comments and corrections2

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Comment in24,009,379Microbiology. Fighting obesity with bacteria.https://conductscience.org/library/papers/24009379PubMed
Comment in24,202,385Slimming down via the microbiota.https://conductscience.org/library/papers/24202385PubMed

References74

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
120,441,597Direct sequencing of the human microbiome readily reveals community differences.Genome Biol2010https://conductscience.org/library/papers/20441597PubMed
222,546,860The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans.J Clin Invest2012https://conductscience.org/library/papers/22546860PubMed
318,796,545Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents.Am J Physiol Endocrinol Metab2008https://conductscience.org/library/papers/18796545PubMed
416,922,306Phylogenetic clustering and overdispersion in bacterial communities.Ecology2006https://conductscience.org/library/papers/16922306PubMed
518,177,724Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.Cell Metab2008https://conductscience.org/library/papers/18177724PubMed
619,356,713A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.Cell Metab2009https://conductscience.org/library/papers/19356713PubMed
722,506,074Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.PLoS One2012https://conductscience.org/library/papers/22506074PubMed
822,030,749The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins.Sci Transl Med2011https://conductscience.org/library/papers/22030749PubMed
922,905,200Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome.PLoS One2012https://conductscience.org/library/papers/22905200PubMed
1022,184,244Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease.Proc Natl Acad Sci U S A2012https://conductscience.org/library/papers/22184244PubMed

1 to 10 of 74

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Cited by2,058

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,852 citations.

PMIDTitleJournalYearIn PapersSource
42,979,661Dietary butyrate alleviates high-fat diet-induced colonic mucosal impairment accompanied by increased gut-derived indole-3-acetic acid and enhanced PPARγ signaling.Front Endocrinol (Lausanne)2026https://conductscience.org/library/papers/42979661PubMed
42,974,155The role of the gut microbiome in the regulation of high-altitude adaptation.Imeta2026https://conductscience.org/library/papers/42974155PubMed
42,955,256Gut microbiota as a key player in diabetes mellitus: mechanisms, dysbiosis, and emerging interventions.Folia Microbiol (Praha)2026https://conductscience.org/library/papers/42955256PubMed
42,923,262Dietary, lifestyle, and host determinants of microbiota-host interactions.Front Microbiomes2026https://conductscience.org/library/papers/42923262PubMed
42,909,040Acarbose differentially affects gut microbial metabolism of maltose and sucrose, distinctly modulating host metabolism.iScience2026https://conductscience.org/library/papers/42909040PubMed
42,902,048Metagenomic analysis of oral microbiota in Chinese children with obesity.Int Microbiol2026https://conductscience.org/library/papers/42902048PubMed
42,899,031Faecal microbiota transplant revisited - potential metabolic outcomes of regional microbiome mismatches.Microbiome Res Rep2026https://conductscience.org/library/papers/42899031PubMed
42,871,959Maternal Diglyceride Diet Attenuates Selected Metabolic Effects of Maternal High-Fat Feeding in Offspring via Energy Metabolism and Microbiota Modulation.Food Sci Nutr2026https://conductscience.org/library/papers/42871959PubMed
42,870,945Saccharomyces boulardii reduces food intake and attenuates weight gain in diet-induced obese mice: links to gut microbial, metabolic, and immune remodeling.Front Immunol2026https://conductscience.org/library/papers/42870945PubMed
42,845,372D-Mannose treats obesity by increasing adipose Treg cells and suppressing gut Firmicutes.bioRxiv2026https://conductscience.org/library/papers/42845372PubMed

1 to 10 of 2,058

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
CDH111,009PubTator's text mininghttps://conductscience.org/library/genes/1009NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE48861

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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