Paper · 2569481

A physiologic role for somatostatin 28 as a regulator of insulin secretion.

D'Alessio DA and 3 others. J Clin Invest, 1989. Cited by 56 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A physiologic role for somatostatin 28 as a regulator of insulin secretion. Papers, record 2569481. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2569481

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A physiologic role for somatostatin 28 as a regulator of insulin secretion.; PubMed
Journal: J Clin Invest; PubMed
Year: 1989; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2569481/; PubMed
DOI: https://doi.org/10.1172/jci114246; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC329729/; PubMed
The journal: https://conductscience.org/library/journal-index/7802877; PubMed
Citations, by iCite: 56; iCite
Relative citation ratio, by iCite: 1.73; iCite
Revised in PubMed: 2018-12-17; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	D'Alessio DA	D A
2	Sieber C	C
3	Beglinger C	C
4	Ensinck JW	J W

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Insulin	Major topic
Somatostatin	Major topic
Administration, Oral
Adult
Arginine
Dietary Fats
Humans
Infusions, Intravenous
Insulin Secretion
Male
Middle Aged
Protein Precursors
Secretin
Somatostatin-28

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
AM02456	NIADDK NIH HHS	United States	P01AM002456	PubMed and NIH	NIH RePORTER
AM07247	NIADDK NIH HHS	United States		PubMed	PubMed
R01-DK34397	NIDDK NIH HHS	United States	R01DK034397	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References34

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	2,883,057	Pancreatic somatostatin is a mediator of glucagon inhibition by hyperglycemia.	Diabetes	1987	https://conductscience.org/library/papers/2883057	PubMed
2	3,543,057	Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.	J Clin Invest	1987	https://conductscience.org/library/papers/3543057	PubMed
3	2,884,233	Circulating somatostatin. Physiological regulator of pancreatic function?	J Clin Invest	1987	https://conductscience.org/library/papers/2884233	PubMed
4	2,884,887	Role of pancreatic somatostatin in determining glucagon response to arginine and morphine.	Am J Physiol	1987	https://conductscience.org/library/papers/2884887	PubMed
5	2,890,658	Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography.	J Clin Invest	1987	https://conductscience.org/library/papers/2890658	PubMed
6	5,666,465	Studies of a simplified plasma insulin immunoassaay using cellulose powder.	Diabetes	1968	https://conductscience.org/library/papers/5666465	PubMed
7	4,340,616	Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma.	J Clin Endocrinol Metab	1972	https://conductscience.org/library/papers/4340616	PubMed
8	1,108,017	Does somatostatin inhibition of insulin secretion involve two mechanisms of action?	Proc Natl Acad Sci U S A	1976	https://conductscience.org/library/papers/1108017	PubMed
9	932,174	The insulinotropic effect of endogenous gastric inhibitory polypeptide in normal subjects.	J Clin Endocrinol Metab	1976	https://conductscience.org/library/papers/932174	PubMed
10	932,179	The effect of rate and dose of glucose infusion on the acute insulin response in man.	J Clin Endocrinol Metab	1976	https://conductscience.org/library/papers/932179	PubMed

1 to 10 of 34

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Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 56 citations.

PMID	Title	Journal	Year	In Papers	Source
35,775,723	GLP-1 Receptor Blockade Reduces Stimulated Insulin Secretion in Fasted Subjects With Low Circulating GLP-1.	J Clin Endocrinol Metab	2022	https://conductscience.org/library/papers/35775723	PubMed
34,667,280	The physiological role of β-cell heterogeneity in pancreatic islet function.	Nat Rev Endocrinol	2022	https://conductscience.org/library/papers/34667280	PubMed
33,481,251	Acute hyperglycaemia enhances both vascular endothelial function and cardiac and skeletal muscle microvascular function in healthy humans.	J Physiol	2022	https://conductscience.org/library/papers/33481251	PubMed
31,065,475	Clinical remission of an inoperable malignant insulinoma by the combination treatment with octreotide and everolimus.	J Gen Fam Med	2019	https://conductscience.org/library/papers/31065475	PubMed
30,658,665	Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations.	Mol Brain	2019	https://conductscience.org/library/papers/30658665	PubMed
26,867,223	Late Presentation of Fulminant Necrotizing Enterocolitis in a Child with Hyperinsulinism on Octreotide Therapy.	Horm Res Paediatr	2016	https://conductscience.org/library/papers/26867223	PubMed
26,441,635	Association of Pancreatic Polypeptide with Mild Cognitive Impairment Varies by APOE ε4 Allele.	Front Aging Neurosci	2015	https://conductscience.org/library/papers/26441635	PubMed
25,651,184	Suppression of insulin production and secretion by a decretin hormone.	Cell Metab	2015	https://conductscience.org/library/papers/25651184	PubMed
25,019,573	Pancreatic polypeptide inhibits somatostatin secretion.	FEBS Lett	2014	https://conductscience.org/library/papers/25019573	PubMed
22,586,489	Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin.	PLoS One	2012	https://conductscience.org/library/papers/22586489	PubMed

1 to 10 of 11

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Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
GCG	2,641	PubTator's text mining	https://conductscience.org/library/genes/2641	NCBI Gene
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
SCT	6,343	PubTator's text mining	https://conductscience.org/library/genes/6343	NCBI Gene
SST	6,750	PubTator's text mining	https://conductscience.org/library/genes/6750	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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