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Paper · 269383

phiX174 cistron A protein is a multifunctional enzyme in DNA replication.

Eisenberg S and 2 others. Proc Natl Acad Sci U S A, 1977. Cited by 241 papers, by iCite.

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ConductScience Library. phiX174 cistron A protein is a multifunctional enzyme in DNA replication. Papers, record 269383. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/269383

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
phiX174 cistron A protein is a multifunctional enzyme in DNA replication.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
241
iCite
Relative citation ratio, by iCite
5.27
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Eisenberg SS
2Griffith JJ
3Kornberg AA

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ColiphagesMajor topic
DNA ReplicationMajor topic
DNA, SuperhelicalMajor topic
Genes, ViralMajor topic
Viral ProteinsMajor topic
DNA Restriction Enzymes
DNA, Single-Stranded
Deoxyribonucleoproteins
Microscopy, Electron

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References19

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,068,461Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1068461PubMed
2138,139A mechanism of duplex DNA replication revealed by enzymatic studies of phage phi X174: catalytic strand separation in advance of replication.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/138139PubMed
3870,828Nucleotide sequence of bacteriophage phi X174 DNA.Nature1977https://conductscience.org/library/papers/870828PubMed
4789,914Bacterial rep- mutations that block development of small DNA bacteriophages late in infection.J Virol1976https://conductscience.org/library/papers/789914PubMed
51,067,608Enzymatic replication of viral and complementary strands of duplex DNA of phage phiX174 proceeds by seprate mechanisms.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1067608PubMed
64,566,449A DNA-unwinding protein isolated from Escherichia coli: its interaction with DNA and with DNA polymerases.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4566449PubMed
74,598,307Isolation and function of the gene A initiator of bacteriophage phi-chi 174, a highly specific DNA endonuclease.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4598307PubMed
84,559,689The rep mutation. II. Its effect on Escherichia coli and on the replication of bacteriophage phi X174.Virology1972https://conductscience.org/library/papers/4559689PubMed
94,891,987DNA replication: the rolling circle model.Cold Spring Harb Symp Quant Biol1968https://conductscience.org/library/papers/4891987PubMed
104,927,945Interaction between DNA and an Escherichia coli protein omega.J Mol Biol1971https://conductscience.org/library/papers/4927945PubMed

1 to 10 of 19

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Cited by100

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 241 citations.

PMIDTitleJournalYearIn PapersSource
42,383,796Periodic genome sequences facilitate packaging in a single-stranded DNA virus.J Virol2026https://conductscience.org/library/papers/42383796PubMed
38,305,183Disenfranchised DNA: biochemical analysis of mutant øX174 DNA-binding proteins may further elucidate the evolutionary significance of the unessential packaging protein A.J Virol2024https://conductscience.org/library/papers/38305183PubMed
38,051,309The crystal structure of the human smacovirus 1 Rep domain.Acta Crystallogr F Struct Biol Commun2023https://conductscience.org/library/papers/38051309PubMed
37,897,358Structural and functional investigation of GajB protein in Gabija anti-phage defense.Nucleic Acids Res2023https://conductscience.org/library/papers/37897358PubMed
34,272,238Plasmid hypermutation using a targeted artificial DNA replisome.Sci Adv2021https://conductscience.org/library/papers/34272238PubMed
34,061,891Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome.PLoS Pathog2021https://conductscience.org/library/papers/34061891PubMed
31,797,816Crystal structure of the Wheat dwarf virus Rep domain.Acta Crystallogr F Struct Biol Commun2019https://conductscience.org/library/papers/31797816PubMed
30,952,693Filamentous phages: masters of a microbial sharing economy.EMBO Rep2019https://conductscience.org/library/papers/30952693PubMed
30,060,236The 2B subdomain of Rep helicase links translocation along DNA with protein displacement.Nucleic Acids Res2018https://conductscience.org/library/papers/30060236PubMed
24,005,675Many ways to loop DNA.J Biol Chem2013https://conductscience.org/library/papers/24005675PubMed

1 to 10 of 100

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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