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Paper29912

The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets.

Sener A and 7 others. J Clin Invest, 1978. Cited by 89 papers, by iCite.

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ConductScience Library. The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. Papers, record 29912. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29912

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets.
PubMed
Journal
J Clin Invest
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
89
iCite
Relative citation ratio, by iCite
3.28
iCite
Revised in PubMed
2018-12-17
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sener AA
2Hutton JCJ C
3Kawazu SS
4Boschero ACA C
5Somers GG
6Devis GG
7Herchuelz AA
8Malaisse WJW J

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AmmoniaMajor topic
InsulinMajor topic
Islets of LangerhansMajor topic
Animals
Cations
Female
Glucose
Glyceraldehyde
Hydrogen-Ion Concentration
Insulin Secretion
Proinsulin
Pyridines
Rats
Water

Source PubMed

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,095,722Pancreatic islet cells: effects of monosaccharides, glycolytic intermediates and metabolic inhibitors on membrane potential and electrical activity.J Physiol1975https://conductscience.org/library/papers/1095722PubMed
21,103,368Diabetogenic effect and inhibition of insulin secretion induced in normal rats by ammonium infusions.Diabetologia1975https://conductscience.org/library/papers/1103368PubMed
313,654,506Calculation of intracellular pH from the distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO); application to skeletal muscle of the dog.J Clin Invest1959https://conductscience.org/library/papers/13654506PubMed
414,337,569ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.Physiol Rev1965https://conductscience.org/library/papers/14337569PubMed
515,869Effect of ammonia on mitochondrial and cytosolic NADH and NADPH systems in isolated rat liver cells.FEBS Lett1977https://conductscience.org/library/papers/15869PubMed
627,353The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.Eur J Biochem1978https://conductscience.org/library/papers/27353PubMed
7334,597Calcium ion fluxes and insulin release in pancreatic islet [proceedings].Biochem Soc Trans1977https://conductscience.org/library/papers/334597PubMed
8336,400Effect of glucose on K+ handling by pancreatic islets.FEBS Lett1977https://conductscience.org/library/papers/336400PubMed
9352,687The stimulus-secretion coupling of glucose-induced insulin release. Cationic and secretory effects of menadione in the endocrine pancreas.Eur J Biochem1978https://conductscience.org/library/papers/352687PubMed
10355,997The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets.Pflugers Arch1978https://conductscience.org/library/papers/355997PubMed
11360,949Regulation of calcium fluxes and their regulatory roles in pancreatic islets.Ann N Y Acad Sci1978https://conductscience.org/library/papers/360949PubMed
124,154,891Mitochondrial nicotinamide nucleotide systems: ammonium chloride responses and associated metabolic transitions in hemoglobin-free perfused rat liver.Hoppe Seylers Z Physiol Chem1974https://conductscience.org/library/papers/4154891PubMed
134,329,423Ammonium ion, a modulator of insulin secretion.Am J Physiol1971https://conductscience.org/library/papers/4329423PubMed
144,333,019The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate.J Clin Invest1972https://conductscience.org/library/papers/4333019PubMed
154,386,347Insulin secretion from toadfish islet tissue stimulated by pyridine nucleotides.Science1968https://conductscience.org/library/papers/4386347PubMed
164,394,424Nitrogen metabolism in the perfused rat liver.Biochim Biophys Acta1970https://conductscience.org/library/papers/4394424PubMed
174,451,683[Decrease of glucose tolerance and insulin secretion after infusion with ammonium salts in normal humans and patients with fatty liver or liver cirrhosis].Biol Gastroenterol (Paris)1974https://conductscience.org/library/papers/4451683PubMed
184,550,490The intracellular pH of mammalian pancreatic -cells.Endocrinology1972https://conductscience.org/library/papers/4550490PubMed
194,568,649Stimulus-secretion coupling of glucose-induced insulin release. X. Effect of glucose on 45 Ca efflux from perifused islets.Am J Physiol1973https://conductscience.org/library/papers/4568649PubMed
204,573,352Dynamics of insulin release and microtubular-microfilamentous system. I. Effect of cytochalasin B.J Clin Invest1973https://conductscience.org/library/papers/4573352PubMed

See all 30 references

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 89 citations.

PMIDTitleJournalYearIn PapersSource
40,896,492Attrition of amino acids in the life span of broiler chickens.Anim Nutr2025https://conductscience.org/library/papers/40896492PubMed
40,487,105A perception that the feed grain basis of reduced-crude protein diets modifies the anabolic impact of insulin on the growth performance of broiler chickens.Anim Nutr2025https://conductscience.org/library/papers/40487105PubMed
37,600,713A pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell.Front Endocrinol (Lausanne)2023https://conductscience.org/library/papers/37600713PubMed
35,837,307pH-Dependence of Glucose-Dependent Activity of Beta Cell Networks in Acute Mouse Pancreatic Tissue Slice.Front Endocrinol (Lausanne)2022https://conductscience.org/library/papers/35837307PubMed
35,160,278Is NMDA-Receptor-Mediated Oxidative Stress in Mitochondria of Peripheral Tissues the Essential Factor in the Pathogenesis of Hepatic Encephalopathy?J Clin Med2022https://conductscience.org/library/papers/35160278PubMed
16,336,655Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice.BMC Endocr Disord2005https://conductscience.org/library/papers/16336655PubMed
15,193,158Nutrient-stimulated insulin secretion in mouse islets is critically dependent on intracellular pH.BMC Endocr Disord2004https://conductscience.org/library/papers/15193158PubMed
6,998,242Evidence for a limited role of NAD(P)H in the nutritional regulation of glucagon release: studies with menadione and NH4Cl.Acta Diabetol Lat1980https://conductscience.org/library/papers/6998242PubMed
6,995,864Metabolic, cationic and secretory effects of hypoglycemic sulfonylureas in pancreatic islets.Naunyn Schmiedebergs Arch Pharmacol1980https://conductscience.org/library/papers/6995864PubMed
6,372,786Effect of glucose on the intracellular pH of pancreatic islet cells.Biochem J1984https://conductscience.org/library/papers/6372786PubMed
6,345,784pH modulation of glucose-induced electrical activity in B-cells: involvement of Na/H and HCO3/Cl antiporters.J Membr Biol1983https://conductscience.org/library/papers/6345784PubMed
6,261,505Regulation of 86Rb outflow from pancreatic islets. IV. Effect of cyclic AMP, dibutyryl-cyclic AMP and theophylline.Acta Diabetol Lat1980https://conductscience.org/library/papers/6261505PubMed
6,245,006Glucoreceptor mechanisms and the control of insulin release and biosynthesis.Diabetologia1980https://conductscience.org/library/papers/6245006PubMed
6,149,148Secretory granules.Experientia1984https://conductscience.org/library/papers/6149148PubMed
6,126,183The internal pH and membrane potential of the insulin-secretory granule.Biochem J1982https://conductscience.org/library/papers/6126183PubMed
3,057,214The gating of nucleotide-sensitive K+ channels in insulin-secreting cells can be modulated by changes in the ratio ATP4-/ADP3- and by nonhydrolyzable derivatives of both ATP and ADP.J Membr Biol1988https://conductscience.org/library/papers/3057214PubMed
1,791,828Hexose metabolism in pancreatic islets. Activation of the Krebs cycle by nutrient secretagogues.Mol Cell Biochem1991https://conductscience.org/library/papers/1791828PubMed
44,196Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans.Biochem J1979https://conductscience.org/library/papers/44196PubMed
43,144The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release.Biochem J1979https://conductscience.org/library/papers/43144PubMed
37,138The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events.Diabetologia1979https://conductscience.org/library/papers/37138PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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