Paper43144

The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release.

Hutton JC and 2 others. Biochem J, 1979. Cited by 34 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release. Papers, record 43144. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/43144

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release.; PubMed
Journal: Biochem J; PubMed
Year: 1979; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/43144/; PubMed
DOI: https://doi.org/10.1042/bj1840303; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1161765/; PubMed
The journal: https://conductscience.org/library/journal-index/2984726R; PubMed
Citations, by iCite: 34; iCite
Relative citation ratio, by iCite: 1.21; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Hutton JC	J C
2	Sener A	A
3	Malaisse WJ	W J

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Insulin	Major topic
Islets of Langerhans	Major topic
Valerates	Major topic
Adenine Nucleotides
Ammonium Chloride
Animals
Calcium
Female
In Vitro Techniques
Insulin Secretion
NAD
NADP
Oxidation-Reduction
Rats
Secretory Rate
Stimulation, Chemical
Vitamin K

Source PubMed

Show 11 more topicsShow fewer topics

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,307,313	Standard Gibbs free energy, enthalpy, and entropy changes as a function of pH and pMg for several reactions involving adenosine phosphates.	J Biol Chem	1969	https://conductscience.org/library/papers/4307313	PubMed
2	4,307,203	Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme.	Anal Biochem	1969	https://conductscience.org/library/papers/4307203	PubMed
3	4,374,939	Cytotoxic effects of streptozotocin and N-nitrosomethylurea on the pancreatic B cells with special regard to the role of nicotinamide-adenine dinucleotide.	Biochem J	1974	https://conductscience.org/library/papers/4374939	PubMed
4	4,921,884	The stimulus-secretion coupling of glucose-induced insulin release. 3. Uptake of 45 calcium by isolated islets of Langerhans.	Endocrinology	1971	https://conductscience.org/library/papers/4921884	PubMed
5	4,922,110	The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.	J Lab Clin Med	1970	https://conductscience.org/library/papers/4922110	PubMed
6	5,333,500	Method for the isolation of intact islets of Langerhans from the rat pancreas.	Diabetes	1967	https://conductscience.org/library/papers/5333500	PubMed
7	16,742,817	Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brain.	Biochem J	1973	https://conductscience.org/library/papers/16742817	PubMed
8	1,687	Effects of alpha-ketomonocarboxylic acids upon insulin secretion and metabolism of isolated pancreatic islets.	Naunyn Schmiedebergs Arch Pharmacol	1975	https://conductscience.org/library/papers/1687	PubMed
9	27,353	The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.	Eur J Biochem	1978	https://conductscience.org/library/papers/27353	PubMed
10	29,912	The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets.	J Clin Invest	1978	https://conductscience.org/library/papers/29912	PubMed
11	37,138	The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events.	Diabetologia	1979	https://conductscience.org/library/papers/37138	PubMed
12	43,143	The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets.	Biochem J	1979	https://conductscience.org/library/papers/43143	PubMed
13	167,775	Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.	Biochem Biophys Res Commun	1975	https://conductscience.org/library/papers/167775	PubMed
14	171,583	Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction.	Nature	1975	https://conductscience.org/library/papers/171583	PubMed
15	205,753	Effects of glucose and acetylcholine on islet tissue NADH and insulin release.	Life Sci	1978	https://conductscience.org/library/papers/205753	PubMed
16	234,166	Effects of bicyclic leucine analogues on insulin release from the perfused rat pancreas and fluorescence of reduced pyridine nucleotides from perifused pancreatic islets.	Life Sci	1975	https://conductscience.org/library/papers/234166	PubMed
17	329,119	Inhibition of p-chloromercuribenzoate- and glucose-induced insulin release in vitro by methylene blue, diamide, and tert-butyl hydroperoxide.	Mol Pharmacol	1977	https://conductscience.org/library/papers/329119	PubMed
18	342,698	Calcium antagonists and islet function: VII. Effect of calcium deprivation.	J Membr Biol	1978	https://conductscience.org/library/papers/342698	PubMed
19	4,149,332	Effect of carbohydrates upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets.	Diabetologia	1973	https://conductscience.org/library/papers/4149332	PubMed
20	4,152,382	Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets.	Diabetologia	1974	https://conductscience.org/library/papers/4152382	PubMed

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Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 34 citations.

PMID	Title	Journal	Year	In Papers	Source
20,736,162	Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion.	J Biol Chem	2010	https://conductscience.org/library/papers/20736162	PubMed
20,499,047	The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.	Diabetologia	2010	https://conductscience.org/library/papers/20499047	PubMed
17,960,358	Fuel-induced amplification of insulin secretion in mouse pancreatic islets exposed to a high sulfonylurea concentration: role of the NADPH/NADP+ ratio.	Diabetologia	2008	https://conductscience.org/library/papers/17960358	PubMed
16,785,608	Adenine nucleotide pattern in rat pancreatic islets exposed to nutrient secretagogues.	Endocrine	2006	https://conductscience.org/library/papers/16785608	PubMed
7,004,965	The stimulus-secretion coupling in glucose-induced insulin release xliv. A possible link between glucose metabolism and phosphate flush.	Diabetologia	1980	https://conductscience.org/library/papers/7004965	PubMed
6,995,864	Metabolic, cationic and secretory effects of hypoglycemic sulfonylureas in pancreatic islets.	Naunyn Schmiedebergs Arch Pharmacol	1980	https://conductscience.org/library/papers/6995864	PubMed
6,775,999	Dynamics of O2 consumption in rat pancreatic islets.	Diabetologia	1980	https://conductscience.org/library/papers/6775999	PubMed
6,387,438	The stimulus-secretion coupling of amino acid-induced insulin release. Inhibition of islet respiration and insulin release by aminooxyacetate.	Mol Cell Biochem	1984	https://conductscience.org/library/papers/6387438	PubMed
6,372,787	Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue.	Biochem J	1984	https://conductscience.org/library/papers/6372787	PubMed
6,092,124	Coupling factors in nutrient-induced insulin release.	Experientia	1984	https://conductscience.org/library/papers/6092124	PubMed
3,050,116	Effects of pyridine nucleotides on the gating of ATP-sensitive potassium channels in insulin-secreting cells.	J Membr Biol	1988	https://conductscience.org/library/papers/3050116	PubMed
43,143	The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets.	Biochem J	1979	https://conductscience.org/library/papers/43143	PubMed

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630

Source NCBI Gene

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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NIH RePORTER's grant and paper linksPublic domain
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PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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