Paper · 301152

The necessity for T cell help for human tonsil B cell responses to pokeweed mitogens: induction of DNA synthesis, immunoglobulin, and specific antibody production with a T cell helper factor produced with pokeweed mitogen.

Insel RA and 1 other. J Immunol, 1977. Cited by 80 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. The necessity for T cell help for human tonsil B cell responses to pokeweed mitogens: induction of DNA synthesis, immunoglobulin, and specific antibody production with a T cell helper factor produced with pokeweed mitogen. Papers, record 301152. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/301152

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The necessity for T cell help for human tonsil B cell responses to pokeweed mitogens: induction of DNA synthesis, immunoglobulin, and specific antibody production with a T cell helper factor produced with pokeweed mitogen.; PubMed
Journal: J Immunol; PubMed
Year: 1977; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/301152/; PubMed
The journal: https://conductscience.org/library/journal-index/2985117R; PubMed
Citations, by iCite: 80; iCite
Relative citation ratio, by iCite: 2.2; iCite
Revised in PubMed: 2008-11-21; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Insel RA	R A
2	Merler E	E

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocytes	Major topic
DNA	Major topic
Immunoglobulins	Major topic
Lectins	Major topic
Palatine Tonsil	Major topic
T-Lymphocytes	Major topic
Antibody Specificity
Dose-Response Relationship, Immunologic
Humans
Immunoglobulin G
Immunoglobulin M
Lymphocyte Activation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 80 citations.

PMID	Title	Journal	Year	In Papers	Source
7,009,976	[The significance of Fc-IgG and Fc-IgM receptors on human T-lymphocytes (author's transl)].	Klin Wochenschr	1981	https://conductscience.org/library/papers/7009976	PubMed
6,605,406	T cell-replacing factor for glucocorticosteroid-induced immunoglobulin production. A unique steroid-dependent cytokine.	J Exp Med	1983	https://conductscience.org/library/papers/6605406	PubMed
6,461,449	The mode of action of splenic suppressor cells in murine plasmacytoma.	Clin Exp Immunol	1981	https://conductscience.org/library/papers/6461449	PubMed
6,454,742	T cell regulation of polyclonal B cell responsiveness. III. Overt T helper and latent T suppressor activities from distinct subpopulations of unstimulated splenic T cells.	J Exp Med	1981	https://conductscience.org/library/papers/6454742	PubMed
2,495,299	The defect in peripheral blood B-cell activation in patients with multiple myeloma is not due to a deficiency in the production of B-cell growth and differentiation factors.	J Clin Immunol	1989	https://conductscience.org/library/papers/2495299	PubMed
527,265	IgA synthesis by peripheral blood mononuclear cells from normal and selectively IgA deficient subjects.	Clin Exp Immunol	1979	https://conductscience.org/library/papers/527265	PubMed
367,653	Severe combined immunodeficiency disease: a model of T-cell dysfunction.	Clin Exp Immunol	1978	https://conductscience.org/library/papers/367653	PubMed
312,259	The production of a soluble human T-lymphocyte derived factor which substitutes for helper T lymphocytes in the in vitro production of immunoglobulin.	Immunology	1979	https://conductscience.org/library/papers/312259	PubMed
309,432	Activation of human B lymphocytes induced by Robinia pseudoacacia lectin in the presence of T cells.	Immunology	1978	https://conductscience.org/library/papers/309432	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/301152

GET https://conductscience.org/api/papers/v1/301152/authors

API reference For AI assistants