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Paper · 312259

The production of a soluble human T-lymphocyte derived factor which substitutes for helper T lymphocytes in the in vitro production of immunoglobulin.

Stevens RH and 2 others. Immunology, 1979. Cited by 41 papers, by iCite.

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ConductScience Library. The production of a soluble human T-lymphocyte derived factor which substitutes for helper T lymphocytes in the in vitro production of immunoglobulin. Papers, record 312259. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/312259

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The production of a soluble human T-lymphocyte derived factor which substitutes for helper T lymphocytes in the in vitro production of immunoglobulin.
PubMed
Journal
Immunology
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
41
iCite
Relative citation ratio, by iCite
1.06
iCite
Revised in PubMed
2018-11-13
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stevens RHR H
2Thiele CJC J
3Saxon AA

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ImmunoglobulinsMajor topic
T-LymphocytesMajor topic
B-Lymphocytes
DNA
Electrophoresis, Polyacrylamide Gel
Humans
In Vitro Techniques
Lymphocyte Activation
Mitosis
Pokeweed Mitogens
Time Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References10

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
165,430Antigen-specific T cell factors: a fine analysis of specificity.J Immunol1977https://conductscience.org/library/papers/65430PubMed
2300,495T-cell regulation of immunoglobulin synthesis and proliferation in pokeweed (Pa-1)-stimulated human lymphocyte cultures.Scand J Immunol1977https://conductscience.org/library/papers/300495PubMed
3301,152
The necessity for T cell help for human tonsil B cell responses to pokeweed mitogens: induction of DNA synthesis, immunoglobulin, and specific antibody production with a T cell helper factor produced with pokeweed mitogen.
J Immunol1977https://conductscience.org/library/papers/301152PubMed
4794,413The T cell dependence of B cell differentiation induced by pokeweed mitogen.J Immunol1976https://conductscience.org/library/papers/794413PubMed
54,137,918Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.Lancet1974https://conductscience.org/library/papers/4137918PubMed
658,834Antigen-non-specific T-cell factor in B-cell activation. Origin, biological properties and failure to show a relationship to H-2.Immunology1976https://conductscience.org/library/papers/58834PubMed
74,605,234The differentiation function of T cell-replacing factor in nu-nu spleen cell cultures.Eur J Immunol1974https://conductscience.org/library/papers/4605234PubMed
84,850,204A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.Eur J Biochem1974https://conductscience.org/library/papers/4850204PubMed
91,102,604Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.J Immunol1975https://conductscience.org/library/papers/1102604PubMed
101,100,764Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.J Exp Med1975https://conductscience.org/library/papers/1100764PubMed

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 41 citations.

PMIDTitleJournalYearIn PapersSource
6,811,607Production of anti-basement membrane-zone antibody by peripheral blood leukocytes of pemphigoid patients.J Clin Immunol1982https://conductscience.org/library/papers/6811607PubMed
6,792,726In vitro antibody response of human lymphocytes.Springer Semin Immunopathol1980https://conductscience.org/library/papers/6792726PubMed
6,605,406T cell-replacing factor for glucocorticosteroid-induced immunoglobulin production. A unique steroid-dependent cytokine.J Exp Med1983https://conductscience.org/library/papers/6605406PubMed
6,603,301Human B cell growth factors overcome T cell-mediated inhibition of specific antibody production: a possible mechanism for the exacerbation of autoimmune disease.Clin Exp Immunol1983https://conductscience.org/library/papers/6603301PubMed
6,600,229Induction of immunoglobulin and antigen-dependent antibody synthesis in human lymphocytes, using supernatants from mitogen-stimulated cultures.Immunology1983https://conductscience.org/library/papers/6600229PubMed
3,380,093Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.Mol Cell Biol1988https://conductscience.org/library/papers/3380093PubMed
3,294,577Effect of cytokines on specific in vitro immunization of human peripheral B lymphocytes against T-cell dependent antigens.Immunology1987https://conductscience.org/library/papers/3294577PubMed
2,934,189Neutralization of T-replacing factor by T8-positive lymphocytes: an important suppressor mechanism operating in the regulation of polyclonal B-cell activation.Clin Exp Immunol1985https://conductscience.org/library/papers/2934189PubMed
1,826,897Pneumococcal polysaccharides complexed with C3d bind to human B lymphocytes via complement receptor type 2.Infect Immun1991https://conductscience.org/library/papers/1826897PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
LOC102723407102,723,407PubTator's text mininghttps://conductscience.org/library/genes/102723407

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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