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Paper · 301172

The specificity of T-cell helper factor in man.

Geha RS and 2 others. J Exp Med, 1977. Cited by 77 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The specificity of T-cell helper factor in man. Papers, record 301172. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/301172

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The specificity of T-cell helper factor in man.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
77
iCite
Relative citation ratio, by iCite
1.91
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Geha RSR S
2Mudawwar FF
3Schneeberger EE

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
T-LymphocytesMajor topic
Antibody Formation
Antibody-Producing Cells
Antigens
B-Lymphocytes
DNA
Dose-Response Relationship, Drug
Humans
Immunity
Immunoglobulin G
Immunosorbents
Mitosis
Tetanus Toxoid

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,299,034THE FLOCCULATION TEST AND THE LAW OF MASS ACTION.J Immunol1965https://conductscience.org/library/papers/14299034PubMed
2792,335Triggering of human peripheral blood B cells: polyclonal induction and modulation of an in vitro PFC response.J Immunol1976https://conductscience.org/library/papers/792335PubMed
34,200,776
Interaction of human thymus-derived and non-thymus-derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes.
J Exp Med1973https://conductscience.org/library/papers/4200776PubMed
44,503,682Replacement of T-cell function by a T-cell product.Nat New Biol1972https://conductscience.org/library/papers/4503682PubMed
54,132,599Editorial: Immune activation of B cells: evidence for 'one nonspecific triggering signal' not delivered by the Ig receptors.Scand J Immunol1974https://conductscience.org/library/papers/4132599PubMed
64,169,033Chromic chloride: a coupling reagent for passive hemagglutination reactions.J Immunol1967https://conductscience.org/library/papers/4169033PubMed
74,273,650Mode of action of a supernatant activity from T-cell cultures that nonspecifically stimulates the humoral immune response.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4273650PubMed
84,610,078Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.J Exp Med1974https://conductscience.org/library/papers/4610078PubMed
958,031Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources.J Immunol1976https://conductscience.org/library/papers/58031PubMed
1058,834Antigen-non-specific T-cell factor in B-cell activation. Origin, biological properties and failure to show a relationship to H-2.Immunology1976https://conductscience.org/library/papers/58834PubMed

1 to 10 of 23

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 77 citations.

PMIDTitleJournalYearIn PapersSource
39,774,671Neuro-Behçet's disease: an update of clinical diagnosis, biomarkers, and immunopathogenesis.Clin Exp Immunol2025https://conductscience.org/library/papers/39774671PubMed
7,471,516PPD-induced viral antibody production in human blood lymphocytes.Clin Exp Immunol1980https://conductscience.org/library/papers/7471516PubMed
7,105,493Kinetics of specific in vitro antibody production following influenza immunization.Clin Exp Immunol1982https://conductscience.org/library/papers/7105493PubMed
7,033,287
Immunoglobulin production induced in vitro by glucocorticoid hormones: T cell-dependent stimulation of immunoglobulin production without B cell proliferation in cultures of human peripheral blood lymphocytes.
J Clin Invest1981https://conductscience.org/library/papers/7033287PubMed
7,007,219Purification and properties of a factor from leukaemic T cells which non-specifically enhances the antibody response.Immunology1981https://conductscience.org/library/papers/7007219PubMed
6,965,306Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.J Exp Med1980https://conductscience.org/library/papers/6965306PubMed
6,766,981Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function.J Exp Med1980https://conductscience.org/library/papers/6766981PubMed
6,744,667Regulation by muramyl dipeptide (MDP) of the lymphoproliferative responses and polyclonal activation of human peripheral blood mononuclear cells.Clin Exp Immunol1984https://conductscience.org/library/papers/6744667PubMed
6,605,406T cell-replacing factor for glucocorticosteroid-induced immunoglobulin production. A unique steroid-dependent cytokine.J Exp Med1983https://conductscience.org/library/papers/6605406PubMed
6,454,516Polyclonal human T lymphocyte activation results in the secondary functional activation of the human B lymphocyte.Clin Exp Immunol1981https://conductscience.org/library/papers/6454516PubMed

1 to 10 of 22

See all 22 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
ALB213PubTator's text mininghttps://conductscience.org/library/genes/213

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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