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Paper · 301550

The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.

Wilson DB and 3 others. J Exp Med, 1977. Cited by 70 papers, by iCite.

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ConductScience Library. The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens. Papers, record 301550. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/301550

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
70
iCite
Relative citation ratio, by iCite
1.37
iCite
Revised in PubMed
2019-05-08
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Wilson DBD B
2Lindahl KFK F
3Wilson DHD H
4Sprent JJ

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Histocompatibility AntigensMajor topic
IsoantigensMajor topic
NitrobenzenesMajor topic
T-LymphocytesMajor topic
TrinitrobenzenesMajor topic
Animals
Cell Separation
Cells, Cultured
Cytotoxicity Tests, Immunologic
Genotype
In Vitro Techniques
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Rats
Rats, Inbred F344
Rats, Inbred Strains

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1233,899Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.J Exp Med1977https://conductscience.org/library/papers/233899PubMed
2233,898Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro.J Exp Med1977https://conductscience.org/library/papers/233898PubMed
362,016H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.J Exp Med1976https://conductscience.org/library/papers/62016PubMed
41,087,327Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.J Exp Med1976https://conductscience.org/library/papers/1087327PubMed
54,400,172Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1 hybrid rats.Nat New Biol1971https://conductscience.org/library/papers/4400172PubMed
64,133,310The clonal nature of allo-antigen-sensitive small lymphocytes in the recirculating pool of normal rats.Aust J Exp Biol Med Sci1974https://conductscience.org/library/papers/4133310PubMed
758,040
Specific selection of cytotoxic effector cells: the generation of cytotoxic T cells in rat thoracic duct lymphocyte populations positively or negatively selected for reactivity to specific strong histocompatibility alloantigens.
J Immunol1976https://conductscience.org/library/papers/58040PubMed
858,463Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.Transplant Rev1976https://conductscience.org/library/papers/58463PubMed
956,402SPECIFIC positive and negative selection of rat lymphocytes reactive to strong histocompatibility antigens: activation with alloantigens in vitro and in vivo.J Immunol1976https://conductscience.org/library/papers/56402PubMed
104,547,153Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.Eur J Immunol1974https://conductscience.org/library/papers/4547153PubMed

1 to 10 of 18

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Cited by23

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 70 citations.

PMIDTitleJournalYearIn PapersSource
6,980,965Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus.J Exp Med1982https://conductscience.org/library/papers/6980965PubMed
6,973,002H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.J Exp Med1981https://conductscience.org/library/papers/6973002PubMed
6,969,780Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.J Exp Med1981https://conductscience.org/library/papers/6969780PubMed
6,967,190MHC restriction, self-tolerance and the thymus.Nature1980https://conductscience.org/library/papers/6967190PubMed
6,965,308Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.J Exp Med1980https://conductscience.org/library/papers/6965308PubMed
6,792,318Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.J Exp Med1981https://conductscience.org/library/papers/6792318PubMed
6,455,762T cell recognition of antigen in vivo: role of the H-2 complex.Springer Semin Immunopathol1980https://conductscience.org/library/papers/6455762PubMed
6,261,255
H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.
Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6261255PubMed
6,180,982Multiple cytolytic T-cell clones with distinct cross-reactivity patterns coexist in anti-self + hapten cell lines.Immunogenetics1982https://conductscience.org/library/papers/6180982PubMed
6,173,458The collaborative phenotype of secondary B cells is determined by T lymphocytes during in vivo immunization.J Exp Med1982https://conductscience.org/library/papers/6173458PubMed

1 to 10 of 23

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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