Paper · 305113

Switch in immunoglobulin class production observed in single clones of committed lymphocytes.

Wabl MR and 2 others. Science, 1978. Cited by 66 papers, by iCite.

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ConductScience Library. Switch in immunoglobulin class production observed in single clones of committed lymphocytes. Papers, record 305113. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/305113

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Switch in immunoglobulin class production observed in single clones of committed lymphocytes.; PubMed
Journal: Science; PubMed
Year: 1978; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/305113/; PubMed
DOI: https://doi.org/10.1126/science.305113; PubMed
The journal: https://conductscience.org/library/journal-index/0404511; PubMed
Citations, by iCite: 66; iCite
Relative citation ratio, by iCite: 1.48; iCite
Revised in PubMed: 2019-06-18; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Wabl MR	M R
2	Forni L	L
3	Loor F	F

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocytes	Major topic
Immunoglobulin G	Major topic
Immunoglobulin M	Major topic
Animals
Cells, Cultured
Clone Cells
Cytoplasm
Immunoglobulin Fc Fragments
Mice
Receptors, Antigen, B-Cell
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 66 citations.

PMID	Title	Journal	Year	In Papers	Source
7,400,356	Immunoglobulin synthesis by neoplastic cells: models of a clonal transition from IgM to IgG synthesis.	J Clin Pathol	1980	https://conductscience.org/library/papers/7400356	PubMed
7,252,371	Optimal strategies in immunology III. The IgM-IgG switch.	J Math Biol	1980	https://conductscience.org/library/papers/7252371	PubMed
7,019,378	Idiotype profile of an immune response. I. Contrasts in idiotypic dominance between primary and secondary responses and between IgM and IgG plaque-forming cells.	J Exp Med	1981	https://conductscience.org/library/papers/7019378	PubMed
6,977,611	T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch.	J Exp Med	1982	https://conductscience.org/library/papers/6977611	PubMed
6,975,683	Production of human anti-thyroglobulin in vitro. III. The role of immunoglobulin-bearing cells.	Clin Exp Immunol	1981	https://conductscience.org/library/papers/6975683	PubMed
6,801,527	Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line.	Nature	1982	https://conductscience.org/library/papers/6801527	PubMed
6,787,596	Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.	Proc Natl Acad Sci U S A	1981	https://conductscience.org/library/papers/6787596	PubMed
6,776,537	Successive switching of antibody isotypes expressed within the lines of a B-cell clone.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6776537	PubMed
6,765,193	Intraclonal diversification in immunoglobulin isotype secretion: an analysis of switch probabilities.	EMBO J	1982	https://conductscience.org/library/papers/6765193	PubMed
6,437,232	Immunohistologic characterization of two malignant lymphomas of germinal center type (centroblastic/centrocytic and centrocytic) with monoclonal antibodies. Follicular and diffuse lymphomas of small-cleaved-cell type are related but distinct entities.	Am J Pathol	1984	https://conductscience.org/library/papers/6437232	PubMed

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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