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Paper · 6776537

Successive switching of antibody isotypes expressed within the lines of a B-cell clone.

Gearhart PJ and 2 others. Proc Natl Acad Sci U S A, 1980. Cited by 91 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Successive switching of antibody isotypes expressed within the lines of a B-cell clone. Papers, record 6776537. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6776537

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Successive switching of antibody isotypes expressed within the lines of a B-cell clone.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1980
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
91
iCite
Relative citation ratio, by iCite
2.19
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gearhart PJP J
2Hurwitz JLJ L
3Cebra JJJ J

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Gene Expression RegulationMajor topic
Immunoglobulin AllotypesMajor topic
Animals
Clone Cells
Immunoglobulin A
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin M
Immunoglobulin Variable Region
Mice
Mice, Inbred Strains
Models, Genetic
Radioimmunoassay
Spleen

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
5-R01-CA25507NCI NIH HHSUnited StatesR01CA025507PubMed and NIHNIH RePORTER
AI-AM14480NIAID NIH HHSUnited StatesPubMedPubMed
AI09652NIAID NIH HHSUnited StatesPubMedPubMed
P01AI014480NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
170,311Origin and differentiation of lymphocytes involved in the secretory IgA responses.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/70311PubMed
272,109Idiotypes on galactan binding myeloma proteins and anti-galactan antibodies in mice.J Immunol1977https://conductscience.org/library/papers/72109PubMed
3303,743Non-sequential expression of multiple immunoglobulin classes by isolated B-cell clones.Nature1977https://conductscience.org/library/papers/303743PubMed
4415,255Idiotype sharing by murine strains differing in immunoglobulin allotype.Nature1978https://conductscience.org/library/papers/415255PubMed
5305,113Switch in immunoglobulin class production observed in single clones of committed lymphocytes.Science1978https://conductscience.org/library/papers/305113PubMed
6351,064Sequential expression of immunoglobulin on developing mouse B lymphocytes: a systematic survey that suggests a model for the generation of immunoglobulin isotype diversity.J Immunol1978https://conductscience.org/library/papers/351064PubMed
797,665Organization of immunoglobulin heavy chain genes and allelic deletion model.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/97665PubMed
8308,089The switch from IgM to IgG secretion in single mitogen-stimulated B-cell clones.J Exp Med1978https://conductscience.org/library/papers/308089PubMed
9357,656Ig-isotype diversity generated in antibody-forming cells of the mouse.J Immunol1978https://conductscience.org/library/papers/357656PubMed
10105,075Differentiated B lymphocytes. Potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load.J Exp Med1979https://conductscience.org/library/papers/105075PubMed

1 to 10 of 25

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Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 91 citations.

PMIDTitleJournalYearIn PapersSource
36,851,695How Estrogen, Testosterone, and Sex Differences Influence Serum Immunoglobulin Isotype Patterns in Mice and Humans.Viruses2023https://conductscience.org/library/papers/36851695PubMed
31,703,914Matters of life and death: How estrogen and estrogen receptor binding to the immunoglobulin heavy chain locus may influence outcomes of infection, allergy, and autoimmune disease.Cell Immunol2019https://conductscience.org/library/papers/31703914PubMed
23,143,476Differential localization and function of antibody-forming cells responsive to inactivated or live-attenuated influenza virus vaccines.Int Immunol2013https://conductscience.org/library/papers/23143476PubMed
20,407,589Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials.Viruses2010https://conductscience.org/library/papers/20407589PubMed
15,051,760Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions.J Exp Med2004https://conductscience.org/library/papers/15051760PubMed
6,977,611T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch.J Exp Med1982https://conductscience.org/library/papers/6977611PubMed
6,972,986Special features of the priming process for a secretory IgA response. B cell priming with cholera toxin.J Exp Med1981https://conductscience.org/library/papers/6972986PubMed
6,809,880Isotype commitment in the in vivo immune responses. I. Antigen-dependent specific and polyclonal plaque-forming cell responses by B lymphocytes induced to extensive proliferation.J Exp Med1982https://conductscience.org/library/papers/6809880PubMed
6,806,822DNA rearrangements in MPC-11 immunoglobulin heavy chain class-switch variants.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6806822PubMed
6,801,181Human b-cell differentiation. I. Analysis of immunoglobulin heavy chain switching using monoclonal anti-immunoglobulin M, G, and A antibodies and pokeweed mitogen-induced plasma cell differentiation.J Exp Med1982https://conductscience.org/library/papers/6801181PubMed

1 to 10 of 30

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
CD79A973PubTator's text mininghttps://conductscience.org/library/genes/973

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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