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Paper307703

Treatment of experimental allergic encephalomyelitis with an inhibitor of cathepsin D (pepstatin).

Boehme DH and 3 others. Neurochem Res, 1978. Cited by 26 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Treatment of experimental allergic encephalomyelitis with an inhibitor of cathepsin D (pepstatin). Papers, record 307703. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/307703

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Treatment of experimental allergic encephalomyelitis with an inhibitor of cathepsin D (pepstatin).
PubMed
Journal
Neurochem Res
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
26
iCite
Relative citation ratio, by iCite
0.83
iCite
Revised in PubMed
2019-08-19
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Boehme DHD H
2Umezawa HH
3Hashim GG
4Marks NN

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Encephalomyelitis, Autoimmune, ExperimentalMajor topic
OligopeptidesMajor topic
PepstatinsMajor topic
Animals
Guinea Pigs
Leupeptins
Mice
Pertussis Vaccine
Rats
Rats, Inbred Lew
Spinal Cord

Source PubMed

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,274,574Effects of protease inhibitors on liver regeneration.Biochem Biophys Res Commun1973https://conductscience.org/library/papers/4274574PubMed
275,170Myelin basic protein: structure, function and antigenic determinants.Immunol Rev1978https://conductscience.org/library/papers/75170PubMed
314,313,493ENCEPHALITOGEN-INDUCED INHIBITION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: PREVENTION, SUPPRESSION AND THERAPY.Ann N Y Acad Sci1965https://conductscience.org/library/papers/14313493PubMed
4843,913Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis.Brain Res1977https://conductscience.org/library/papers/843913PubMed
54,621,748Treatment of experimental allergic encephalomyelitis with encephalitogenic basic proteins.Proc Soc Exp Biol Med1972https://conductscience.org/library/papers/4621748PubMed
64,125,887Prevention of experimental allergic encephalomyelitis by nonencephalitogenic basic peptides.Arch Biochem Biophys1973https://conductscience.org/library/papers/4125887PubMed
71,178,044Direct evidence of importance of lysosomes in degradation of intracellular proteins.Nature1975https://conductscience.org/library/papers/1178044PubMed
85,349,735Studies of cyclophosphamide suppression of experimental allergic encephalomyelitis in Wistar rats.J Immunol1969https://conductscience.org/library/papers/5349735PubMed
946,241Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein.J Immunol1975https://conductscience.org/library/papers/46241PubMed
104,581,126Pentapeptide (pepstatin) inhibition of brain acid proteinase.Science1973https://conductscience.org/library/papers/4581126PubMed
1154,384Suppression and reversal of allergic encephalomyelitis in guinea pigs with a non-encephalitogenic analogue of the tryptophan region of the myelin basic protein.J Immunol1976https://conductscience.org/library/papers/54384PubMed
1224,271,248The breakdown of myelin-bound proteins by intra- and extracellular proteases.Neurochem Res1976https://conductscience.org/library/papers/24271248PubMed
134,263,191Inhibition by pepstatin of human cartilage degradation.Biochem J1972https://conductscience.org/library/papers/4263191PubMed
1470,349Metabolic instability of myelin proteins. Breakdown of basic protein induced by brain cathepsin D.Eur J Biochem1975https://conductscience.org/library/papers/70349PubMed
1524,272,051The role of proteolytic enzymes in demyelination in experimental allergic encephalomyelitis.Neurochem Res1977https://conductscience.org/library/papers/24272051PubMed
164,546,325Proteolytic activity in brain and spinal cord in sensitive and resistant strains of rat and mouse subjected to experimental allergic encephalomyelitis.Brain Res1974https://conductscience.org/library/papers/4546325PubMed
174,130,152Successful treatment of experimental allergic encephalomyelitis (EAE) in guinea pigs with homologous myelin basic protein.J Immunol1974https://conductscience.org/library/papers/4130152PubMed
18125,156[Cathepsin D and the catabolic degradation of proteoglycans in granulomatous tissue].C R Acad Hebd Seances Acad Sci D1975https://conductscience.org/library/papers/125156PubMed

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 26 citations.

PMIDTitleJournalYearIn PapersSource
41,882,284Interferon-β and FTY720 ameliorate progressive CNS inflammation via SOCS1-associated astrocyte signaling.Sci Rep2026https://conductscience.org/library/papers/41882284PubMed
26,075,905Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis.PLoS One2015https://conductscience.org/library/papers/26075905PubMed
9,358,770Mononuclear phagocyte hydrolytic enzyme activity associated with cerebral HIV-1 infection.Am J Pathol1997https://conductscience.org/library/papers/9358770PubMed
7,989,572Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.J Clin Invest1994https://conductscience.org/library/papers/7989572PubMed
6,750,429Observations on the effects of protease inhibitors on the suppression of experimental allergic encephalomyelitis.Neurochem Res1982https://conductscience.org/library/papers/6750429PubMed
6,377,107Proteases of human brain.Neurochem Res1984https://conductscience.org/library/papers/6377107PubMed
3,901,368Proteinases in inflammatory demyelinating disease.Springer Semin Immunopathol1985https://conductscience.org/library/papers/3901368PubMed
2,540,444NPGB-induced inhibition of superoxide anion production by normal Lewis rat macrophages.Neurochem Res1989https://conductscience.org/library/papers/2540444PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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