Paper · 32065590

Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney.

Simic P and 24 others. J Clin Invest, 2020. Cited by 114 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. Papers, record 32065590. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32065590

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney.; PubMed
Journal: J Clin Invest; PubMed
Year: 2020; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/32065590/; PubMed
DOI: https://doi.org/10.1172/jci131190; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7269595/; PubMed
The journal: https://conductscience.org/library/journal-index/7802877; PubMed
Citations, by iCite: 114; iCite
Relative citation ratio, by iCite: 6.4; iCite
Revised in PubMed: 2025-01-03; PubMed

Authors25

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Simic P	Petra
2	Kim W	Wondong
3	Zhou W	Wen
4	Pierce KA	Kerry A
5	Chang W	Wenhan
6	Sykes DB	David B
7	Aziz NB	Najihah B
8	Elmariah S	Sammy
9	Ngo D	Debby
10	Pajevic PD	Paola Divieti

1 to 10 of 25Source PubMed

See all 25 authors

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Acute Kidney Injury	Major topic
Fibroblast Growth Factors	Major topic
Glycerophosphates	Major topic
Kidney	Major topic
Animals
Cell Line
Female
Fibroblast Growth Factor-23
Humans
Male
Metabolomics
Mice
Mice, Knockout
Receptors, Lysophosphatidic Acid

Source PubMed

Grants14

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
K08 DK124568	NIDDK NIH HHS	United States	K08DK124568	PubMed and NIH	NIH RePORTER
P30 DK040561	NIDDK NIH HHS	United States	P30DK040561	PubMed and NIH	NIH RePORTER
R01 NR017399	NINR NIH HHS	United States	R01NR017399	PubMed and NIH	NIH RePORTER
R01 DK116716	NIDDK NIH HHS	United States	R01DK116716	PubMed and NIH	NIH RePORTER
R01 DK081572	NIDDK NIH HHS	United States	R01DK081572	PubMed and NIH	NIH RePORTER
R01 AR067291	NIAMS NIH HHS	United States	R01AR067291	PubMed and NIH	NIH RePORTER
I01 BX003453	BLRD VA	United States	I01BX003453	PubMed and NIH	NIH RePORTER
U01 DK106981	NIDDK NIH HHS	United States	U01DK106981	PubMed and NIH	NIH RePORTER
R01 HL132320	NHLBI NIH HHS	United States	R01HL132320	PubMed and NIH	NIH RePORTER
R01 DK122259	NIDDK NIH HHS	United States	R01DK122259	PubMed	NIH RePORTER

1 to 10 of 14

See all 14 grants

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections3

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers	Source
Comment in	32,065,594	Kidney to bone via bedside to bench…and back?	https://conductscience.org/library/papers/32065594	PubMed
Comment in	32,123,370	Kidney metabolite induces FGF23 rise.	https://conductscience.org/library/papers/32123370	PubMed
Comment in	32,565,191	A new player in the kidney-bone axis: regulation of fibroblast growth factor-23 by renal glycerol-3-phosphate.	https://conductscience.org/library/papers/32565191	PubMed

References62

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	28,877,877	Acute blood loss stimulates fibroblast growth factor 23 production.	Am J Physiol Renal Physiol	2018	https://conductscience.org/library/papers/28877877	PubMed
2	23,401,498	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	Proc Natl Acad Sci U S A	2013	https://conductscience.org/library/papers/23401498	PubMed
3	24,870,543	Mass-spectrometry-based draft of the human proteome.	Nature	2014	https://conductscience.org/library/papers/24870543	PubMed
4	19,131,962	A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow.	Nat Protoc	2009	https://conductscience.org/library/papers/19131962	PubMed
5	26,924,052	Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery.	Kidney Int	2016	https://conductscience.org/library/papers/26924052	PubMed
6	23,923,032	A metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis.	PLoS One	2013	https://conductscience.org/library/papers/23923032	PubMed
7	12,893,936	Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli.	Science	2003	https://conductscience.org/library/papers/12893936	PubMed
8	26,792,657	Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia.	J Bone Miner Res	2016	https://conductscience.org/library/papers/26792657	PubMed
9	19,038,363	Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.	Biochim Biophys Acta	2009	https://conductscience.org/library/papers/19038363	PubMed
10	25,953,900	The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.	J Biol Chem	2015	https://conductscience.org/library/papers/25953900	PubMed

1 to 10 of 62

See all 62 references

Cited by85

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 114 citations.

PMID	Title	Journal	Year	In Papers	Source
42,663,891	FGF23 - A hormone produced by bone and has many faces.	Rev Endocr Metab Disord	2026	https://conductscience.org/library/papers/42663891	PubMed
42,230,703	Fibroblast growth factor-23 as an early biomarker of ischemic acute kidney injury after partial nephrectomy: prospective observational study.	Sci Rep	2026	https://conductscience.org/library/papers/42230703	PubMed
42,116,290	Causal role of serum metabolites in chronic periodontitis: A bidirectional Mendelian randomization and multi-omics integration study.	Medicine (Baltimore)	2026	https://conductscience.org/library/papers/42116290	PubMed
42,105,162	Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions.	Mol Biomed	2026	https://conductscience.org/library/papers/42105162	PubMed
42,051,461	Gut microbiota in chronic kidney disease-mineral and bone disorder: shared mechanisms, disease-specific signatures, and therapeutic prospects.	Front Endocrinol (Lausanne)	2026	https://conductscience.org/library/papers/42051461	PubMed
42,020,815	Broken signals: when the mineralostat alters the cardiovascular system.	Pediatr Nephrol	2026	https://conductscience.org/library/papers/42020815	PubMed
41,906,060	The effects of elevated phosphate on the kidney - damaging the gatekeeper.	Pflugers Arch	2026	https://conductscience.org/library/papers/41906060	PubMed
41,783,857	Changes in bone characteristics precede serum mineral deterioration in a mouse model of early stage chronic kidney disease.	JBMR Plus	2026	https://conductscience.org/library/papers/41783857	PubMed
41,783,140	Heterogeneous regulation of fibroblast growth factor 23 in acute kidney injury, chronic kidney disease, and polycystic kidney disease: mechanisms, diagnostic utility, and clinical implications.	Front Mol Biosci	2026	https://conductscience.org/library/papers/41783140	PubMed
41,767,622	Markers of Mineral Metabolism in Children With CKD Stages 2 to 5D.	Kidney Int Rep	2026	https://conductscience.org/library/papers/41767622	PubMed

1 to 10 of 85

See all 85 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
FGF23	8,074	PubTator's text mining	https://conductscience.org/library/genes/8074	NCBI Gene
GPAM	57,678	PubTator's text mining	https://conductscience.org/library/genes/57678	NCBI Gene
LPAR1	1,902	PubTator's text mining	https://conductscience.org/library/genes/1902	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/32065590

GET https://conductscience.org/api/papers/v1/32065590/authors?page=2

API reference For AI assistants