Paper · 323404

Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro.

Schimpl A and 2 others. J Exp Med, 1977. Cited by 8 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro. Papers, record 323404. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/323404

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro.; PubMed
Journal: J Exp Med; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/323404/; PubMed
DOI: https://doi.org/10.1084/jem.145.5.1216; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2180662/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 8; iCite
Relative citation ratio, by iCite: 0.18; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Schimpl A	A
2	Wecker E	E
3	Hünig T	T

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Immunologic Memory	Major topic
T-Lymphocytes	Major topic
Animals
Antibody-Producing Cells
Antigens
Antilymphocyte Serum
B-Lymphocytes
Cells, Cultured
Dinitrobenzenes
Female
Hemocyanins
Hemolytic Plaque Technique
Immunoglobulin G
Male
Mice
Mice, Inbred DBA
Ovalbumin
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
2	323,405	Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.	J Exp Med	1977	https://conductscience.org/library/papers/323405	PubMed
3	1,085,700	IgG response in vitro. I. The requirement for an intermediate responsive cell type.	Eur J Immunol	1976	https://conductscience.org/library/papers/1085700	PubMed
4	4,503,682	Replacement of T-cell function by a T-cell product.	Nat New Biol	1972	https://conductscience.org/library/papers/4503682	PubMed
5	4,113,234	Specific collaboration between T and B lymphocytes across a cell impermeable membrane in vitro.	Nat New Biol	1972	https://conductscience.org/library/papers/4113234	PubMed
6	4,125,546	Hapten-specific IgE antibody responses in mice. II. Cooperative interactions between adoptively transferred T and B lymphocytes in the development of IgE response.	J Exp Med	1973	https://conductscience.org/library/papers/4125546	PubMed
7	4,128,811	Soluble mediators of T-B interaction.	Eur J Immunol	1973	https://conductscience.org/library/papers/4128811	PubMed
8	4,128,975	Immunogenicity of macrophage-bound antigens: the requirement for hapten and carrier determinants to be on the same molecule for T and B lymphocyte collaboration.	Eur J Immunol	1973	https://conductscience.org/library/papers/4128975	PubMed
9	4,181,830	The requirement of more than one antigenic determinant for immunogenicity.	J Exp Med	1969	https://conductscience.org/library/papers/4181830	PubMed
10	4,144,030	Carrier specificity and the allogeneic effect in mice.	Eur J Immunol	1972	https://conductscience.org/library/papers/4144030	PubMed
11	58,031	Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources.	J Immunol	1976	https://conductscience.org/library/papers/58031	PubMed

1 to 10 of 28

See all 28 references

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 8 citations.

PMID	Title	Journal	Year	In Papers	Source
6,972,901	Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin in vitro.	Immunology	1981	https://conductscience.org/library/papers/6972901	PubMed
6,792,725	How many T cells help one B cell?	Springer Semin Immunopathol	1980	https://conductscience.org/library/papers/6792725	PubMed
6,607,212	T cell help mechanisms in the in vitro antibody response: the role of linked and non-linked recognition interactions.	Immunology	1984	https://conductscience.org/library/papers/6607212	PubMed
6,184,434	Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells.	J Exp Med	1982	https://conductscience.org/library/papers/6184434	PubMed
3,260,034	Differential ability of B cells specific for external vs. internal influenza virus proteins to respond to help from influenza virus-specific T-cell clones in vivo.	Proc Natl Acad Sci U S A	1988	https://conductscience.org/library/papers/3260034	PubMed
2,427,636	Bystander help in primary immune responses in vivo.	J Exp Med	1986	https://conductscience.org/library/papers/2427636	PubMed
562,478	Expression of MuLV GP71-like antigen in normal mouse spleen cells induced by antigenic stimulation.	Nature	1977	https://conductscience.org/library/papers/562478	PubMed
381,769	[Soluble mediators as a means of communication between lymphozytes in immune reactions (author's transl)].	Klin Wochenschr	1979	https://conductscience.org/library/papers/381769	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/323404

GET https://conductscience.org/api/papers/v1/323404/references?page=2

API reference For AI assistants