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Paper · 323405

Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.

Hünig TH and 2 others. J Exp Med, 1977. Cited by 38 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor. Papers, record 323405. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/323405

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
38
iCite
Relative citation ratio, by iCite
0.75
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Hünig THT H
2Schimpl AA
3Wecker EE

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody FormationMajor topic
Immunologic MemoryMajor topic
T-LymphocytesMajor topic
Animals
Antibody-Producing Cells
Antigens
Cells, Cultured
Concanavalin A
Female
Hemocyanins
Hemolytic Plaque Technique
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Nude
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,085,700IgG response in vitro. I. The requirement for an intermediate responsive cell type.Eur J Immunol1976https://conductscience.org/library/papers/1085700PubMed
24,503,682Replacement of T-cell function by a T-cell product.Nat New Biol1972https://conductscience.org/library/papers/4503682PubMed
34,128,811Soluble mediators of T-B interaction.Eur J Immunol1973https://conductscience.org/library/papers/4128811PubMed
458,031Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources.J Immunol1976https://conductscience.org/library/papers/58031PubMed
54,605,234The differentiation function of T cell-replacing factor in nu-nu spleen cell cultures.Eur J Immunol1974https://conductscience.org/library/papers/4605234PubMed
64,576,584Development of primary M, G, and A anti-TNP plaque-forming cell responses in vitro.J Immunol1973https://conductscience.org/library/papers/4576584PubMed
74,568,302Stimulation of IgG antibody response in vitro by T cell-replacing factor.J Exp Med1973https://conductscience.org/library/papers/4568302PubMed
84,545,893Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.J Exp Med1974https://conductscience.org/library/papers/4545893PubMed
94,542,808The role of humoral factors in the initiation of in vitro primary immune responses. 3. Characterization of factors that replace thymus-derived cells.J Immunol1973https://conductscience.org/library/papers/4542808PubMed
104,544,248Autoradiographic studies on the proliferation of antibody-producing cells in vitro.J Exp Med1974https://conductscience.org/library/papers/4544248PubMed

1 to 10 of 16

See all 16 references

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 38 citations.

PMIDTitleJournalYearIn PapersSource
6,972,901Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin in vitro.Immunology1981https://conductscience.org/library/papers/6972901PubMed
6,967,509Activation of murine B lymphocytes by anti-immunoglobulin is an inductive signal leading to immunoglobulin secretion.J Exp Med1980https://conductscience.org/library/papers/6967509PubMed
6,159,447The role of H-2-linked genes in helper T cell function. VII. Expression of I region and immune response genes by B cells in bystander help assays.J Exp Med1980https://conductscience.org/library/papers/6159447PubMed
3,262,707Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication.J Exp Med1988https://conductscience.org/library/papers/3262707PubMed
418,135In vitro analysis of allogeneic lymphocyte interaction. II. I-region control of the activity of a B-cell-derived H-2-restricted allogeneic effect factor and its receptor during B-cell activation.J Exp Med1978https://conductscience.org/library/papers/418135PubMed
381,769[Soluble mediators as a means of communication between lymphozytes in immune reactions (author's transl)].Klin Wochenschr1979https://conductscience.org/library/papers/381769PubMed
323,404
Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro.
J Exp Med1977https://conductscience.org/library/papers/323404PubMed
91,574Thymus dependence of the IgG response: role of T cells is restricted to non-specific rather than antigen-specific factors.Immunology1979https://conductscience.org/library/papers/91574PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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