Paper · 36926834

Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines.

Chen WA and 5 others. ACS Nano, 2023. Cited by 64 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines. Papers, record 36926834. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36926834

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines.; PubMed
Journal: ACS Nano; PubMed
Year: 2023; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/36926834/; PubMed
DOI: https://doi.org/10.1021/acsnano.2c12193; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC10062034/; PubMed
The journal: https://conductscience.org/library/journal-index/101313589; PubMed
Citations, by iCite: 64; iCite
Relative citation ratio, by iCite: 7.55; iCite
Revised in PubMed: 2023-12-12; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Chen WA	Wei-An
2	Chang DY	Deng-Yuan
3	Chen BM	Bing-Mae
4	Lin YC	Yi-Chen
5	Barenholz Y	Yechezekel
6	Roffler SR	Steve R	https://orcid.org/0000-0003-2543-7295

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Polyethylene Glycols	Major topic
Hypothermia	Major topic
Mice
Humans
Animals
Nanomedicine
Histamine
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, SCID
Immunoglobulin G
Immunity, Innate
Liposomes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References95

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,755,943	The role of complement in inflammation and phagocytosis.	Immunol Today	1991	https://conductscience.org/library/papers/1755943	PubMed
2	14,660,743	Mast cells are required for experimental oral allergen-induced diarrhea.	J Clin Invest	2003	https://conductscience.org/library/papers/14660743	PubMed
3	27,804,292	Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population.	Anal Chem	2016	https://conductscience.org/library/papers/27804292	PubMed
4	24,849,101	Anaphylaxis and hypotension after administration of peginesatide.	N Engl J Med	2014	https://conductscience.org/library/papers/24849101	PubMed
5	1,428,729	Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles.	Invest New Drugs	1992	https://conductscience.org/library/papers/1428729	PubMed
6	20,553,005	Time evolution of the nanoparticle protein corona.	ACS Nano	2010	https://conductscience.org/library/papers/20553005	PubMed
7	29,363,548	Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models.	Cancer Res	2018	https://conductscience.org/library/papers/29363548	PubMed
8	22,332,808	Role of the methoxy group in immune responses to mPEG-protein conjugates.	Bioconjug Chem	2012	https://conductscience.org/library/papers/22332808	PubMed
9	23,810,240	Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells.	J Allergy Clin Immunol	2013	https://conductscience.org/library/papers/23810240	PubMed
10	34,533,570	Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System.	JAMA Netw Open	2021	https://conductscience.org/library/papers/34533570	PubMed

1 to 10 of 95

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Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 64 citations.

PMID	Title	Journal	Year	In Papers	Source
42,923,377	Zwitterionic Coatings for Urinary Catheters: Current Progress, Design Principles and Translational Challenges.	ACS Omega	2026	https://conductscience.org/library/papers/42923377	PubMed
42,799,454	Immunogenicity Management Strategies for PEGylated Drug Delivery Systems.	Int J Nanomedicine	2026	https://conductscience.org/library/papers/42799454	PubMed
42,514,893	Anti-PEG Immunogenicity of mRNA-LNP Vaccines in Humans: Evidence for Population-Level Changes in the Anti-PEG Antibody Repertoire.	Pharmaceutics	2026	https://conductscience.org/library/papers/42514893	PubMed
42,400,029	Liposomal drug delivery for lung cancer therapy: progress, challenges, and future perspectives.	Mol Cancer	2026	https://conductscience.org/library/papers/42400029	PubMed
42,193,329	Effect of Short-Anchored PEGylated Lipids on Lipid Nanoparticle Characterization Profiles, Stability, and Efficacy.	Biomedicines	2026	https://conductscience.org/library/papers/42193329	PubMed
42,176,005	Aptamer-conjugated nanoparticles: emerging nano-enabled platforms for rapid and sensitive detection of viral infections.	Arch Microbiol	2026	https://conductscience.org/library/papers/42176005	PubMed
42,125,269	Aptamer-Functionalized Nanocarriers for Bone and Joint Diseases: Engineering Design Rules and Translational Roadmap.	Small Sci	2026	https://conductscience.org/library/papers/42125269	PubMed
42,001,148	Pre-existing anti-polyethylene glycol antibodies in pregnant women and newborns.	J Nanobiotechnology	2026	https://conductscience.org/library/papers/42001148	PubMed
41,942,053	Therapeutic peptides and proteins: Status and developments in drug delivery.	J Control Release	2026	https://conductscience.org/library/papers/41942053	PubMed
41,558,674	AFM-Based Single-Molecule Force Spectroscopy of PEG-Anti-PEG Antibody Interactions.	ACS Appl Bio Mater	2026	https://conductscience.org/library/papers/41558674	PubMed

1 to 10 of 30

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Genes8

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
C5AR1	728	PubTator's text mining	https://conductscience.org/library/genes/728	NCBI Gene
CCR3	1,232	PubTator's text mining	https://conductscience.org/library/genes/1232	NCBI Gene
CD82	3,732	PubTator's text mining	https://conductscience.org/library/genes/3732	NCBI Gene
FCGR2A	2,212	PubTator's text mining	https://conductscience.org/library/genes/2212	NCBI Gene
FCGR3A	2,214	PubTator's text mining	https://conductscience.org/library/genes/2214	NCBI Gene
HSR	338,386	PubTator's text mining	https://conductscience.org/library/genes/338386	NCBI Gene
KIT	3,815	PubTator's text mining	https://conductscience.org/library/genes/3815	NCBI Gene
PCLAF	9,768	PubTator's text mining	https://conductscience.org/library/genes/9768	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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