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Paper36973249

Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.

Trastoy B and 16 others. Nat Commun, 2023. Cited by 24 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Papers, record 36973249. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36973249

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
PubMed
Journal
Nat Commun
PubMed
Year
2023
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
24
iCite
Relative citation ratio, by iCite
2.52
iCite
Revised in PubMed
2026-05-26
PubMed

Authors17

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Trastoy BBeatrizhttps://orcid.org/0000-0002-2178-732X
2Du JJJonathan J
3Cifuente JOJavier Ohttps://orcid.org/0000-0001-5420-121X
4Rudolph LLorenahttps://orcid.org/0000-0002-0218-2747
5García-Alija MMikel
6Klontz EHErik H
7Deredge DDanielhttps://orcid.org/0000-0002-6897-6523
8Sultana NNazneenhttps://orcid.org/0000-0001-9866-4443
9Huynh CGChau G
10Flowers MWMaria W
11Li CChao
12Sastre DEDiego E
13Wang LXLai-Xihttps://orcid.org/0000-0003-4293-5819
14Corzana FFranciscohttps://orcid.org/0000-0001-5597-8127
15Mallagaray AAlvarohttps://orcid.org/0000-0001-5825-4407
16Sundberg EJEric Jhttps://orcid.org/0000-0003-0478-3033
17Guerin MEMarcelo Ehttps://orcid.org/0000-0001-9524-3184

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Glycoside HydrolasesMajor topic
Immune EvasionMajor topic
Humans
Streptococcus pyogenes
Immunoglobulin G
Polysaccharides

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 AI149297NIAID NIH HHSUnited StatesR01AI149297PubMed and NIHNIH RePORTER
R01 GM096973NIGMS NIH HHSUnited StatesR01GM096973PubMedNIH RePORTER

References92

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
121,653,738High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations.Mol Cell Proteomics2011https://conductscience.org/library/papers/21653738PubMed
229,872,004Real-space refinement in PHENIX for cryo-EM and crystallography.Acta Crystallogr D Struct Biol2018https://conductscience.org/library/papers/29872004PubMed
310,891,067Structural basis for the substrate specificity of endo-beta-N-acetylglucosaminidase F(3).Biochemistry2000https://conductscience.org/library/papers/10891067PubMed
433,257,830Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction.Nat Methods2020https://conductscience.org/library/papers/33257830PubMed
526,211,613The Structural Role of Antibody N-Glycosylation in Receptor Interactions.Structure2015https://conductscience.org/library/papers/26211613PubMed
624,469,444Structural insights into neonatal Fc receptor-based recycling mechanisms.J Biol Chem2014https://conductscience.org/library/papers/24469444PubMed
730,190,373Endoglycosidase S Enables a Highly Simplified Clinical Chemistry Procedure for Direct Assessment of Serum IgG Undergalactosylation in Chronic Inflammatory Disease.Mol Cell Proteomics2018https://conductscience.org/library/papers/30190373PubMed
831,362,190Interpretation of medium resolution cryoEM maps of multi-protein complexes.Curr Opin Struct Biol2019https://conductscience.org/library/papers/31362190PubMed
930,693Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.Immunochemistry1978https://conductscience.org/library/papers/30693PubMed
1031,205,015CM01: a facility for cryo-electron microscopy at the European Synchrotron.Acta Crystallogr D Struct Biol2019https://conductscience.org/library/papers/31205015PubMed
1115,574,492Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG.Proc Natl Acad Sci U S A2004https://conductscience.org/library/papers/15574492PubMed
1215,815,974The CCPN data model for NMR spectroscopy: development of a software pipeline.Proteins2005https://conductscience.org/library/papers/15815974PubMed
1318,332,429IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/18332429PubMed
1424,381,156Computational design of a pH-sensitive IgG binding protein.Proc Natl Acad Sci U S A2014https://conductscience.org/library/papers/24381156PubMed
1518,157,137GraFix: sample preparation for single-particle electron cryomicroscopy.Nat Methods2008https://conductscience.org/library/papers/18157137PubMed
1632,130,959Methyl TROSY spectroscopy: A versatile NMR approach to study challenging biological systems.Prog Nucl Magn Reson Spectrosc2020https://conductscience.org/library/papers/32130959PubMed
1711,336,709Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding.Mol Cell2001https://conductscience.org/library/papers/11336709PubMed
1820,887,855GraFix: stabilization of fragile macromolecular complexes for single particle cryo-EM.Methods Enzymol2010https://conductscience.org/library/papers/20887855PubMed
1921,768,335Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.Proc Natl Acad Sci U S A2011https://conductscience.org/library/papers/21768335PubMed
2017,406,304Isotope labeling strategies for the study of high-molecular-weight proteins by solution NMR spectroscopy.Nat Protoc2006https://conductscience.org/library/papers/17406304PubMed

See all 92 references

Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 24 citations.

PMIDTitleJournalYearIn PapersSource
42,445,474Deglycosylation at War: Host N-Glycoprotein Remodeling in Infection and Immunity.Infect Drug Resist2026https://conductscience.org/library/papers/42445474PubMed
42,357,725Development and Immunogenicity of a Five-Antigen Strangles Vaccine Based on Equine Ferritin Nanoparticles in Mice.Vet Sci2026https://conductscience.org/library/papers/42357725PubMed
41,884,853Plasma PFDN2 suppresses head and neck squamous cell carcinoma progression by restricting CD64 on monocyte-driven inflammatory microenvironments.Front Immunol2026https://conductscience.org/library/papers/41884853PubMed
41,781,017Antibody therapeutics with high affinity for FcγRs exacerbate anaphylaxis via FcγR-mediated capture by tumor-associated myeloid cells.J Immunother Cancer2026https://conductscience.org/library/papers/41781017PubMed
41,753,644Group A Streptococcal Virulence Factors and Vaccine Development-An Update.Microorganisms2026https://conductscience.org/library/papers/41753644PubMed
40,813,394A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers.Nat Commun2025https://conductscience.org/library/papers/40813394PubMed
40,610,417The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases.Nat Commun2025https://conductscience.org/library/papers/40610417PubMed
39,877,544Impact of different pathogen classes on the serum N-glycome in septic shock.BBA Adv2025https://conductscience.org/library/papers/39877544PubMed
39,738,071Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota.Nat Commun2024https://conductscience.org/library/papers/39738071PubMed
39,472,448Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway.Cell Death Dis2024https://conductscience.org/library/papers/39472448PubMed
39,437,779Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologies.Cell2024https://conductscience.org/library/papers/39437779PubMed
39,370,779The intricate pathogenicity of Group A Streptococcus: A comprehensive update.Virulence2024https://conductscience.org/library/papers/39370779PubMed
38,938,812Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.JACS Au2024https://conductscience.org/library/papers/38938812PubMed
38,879,612Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate.Nat Commun2024https://conductscience.org/library/papers/38879612PubMed
38,598,628Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.Sci Adv2024https://conductscience.org/library/papers/38598628PubMed

Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
C1QA712PubTator's text mininghttps://conductscience.org/library/genes/712NCBI Gene
CD80941PubTator's text mininghttps://conductscience.org/library/genes/941NCBI Gene
FCGRT2,217PubTator's text mininghttps://conductscience.org/library/genes/2217NCBI Gene
FCP12,221PubTator's text mininghttps://conductscience.org/library/genes/2221NCBI Gene
GGH8,836PubTator's text mininghttps://conductscience.org/library/genes/8836NCBI Gene
IGHG33,502PubTator's text mininghttps://conductscience.org/library/genes/3502NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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