Paper386136
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone.
Goeddel DV and 9 others. Nature, 1979. Cited by 422 papers, by iCite.
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ConductScience Library. Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Papers, record 386136. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/386136
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics10
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| DNA, Recombinant | Major topic |
| Escherichia coli | Major topic |
| Growth Hormone | Major topic |
| Base Sequence | |
| Genes | |
| Humans | |
| Plasmids | |
| Protein Precursors | |
| RNA, Messenger | |
| Radioimmunoassay |
Source PubMed
References23
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 75,887 | Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I. | J Biol Chem | 1978 | https://conductscience.org/library/papers/75887 | PubMed |
| 2 | 325,648 | Rat insulin genes: construction of plasmids containing the coding sequences. | Science | 1977 | https://conductscience.org/library/papers/325648 | PubMed |
| 3 | 364,320 | Synthesis of growth hormone by bacteria. | Nature | 1978 | https://conductscience.org/library/papers/364320 | PubMed |
| 4 | 1,090,931 | Proteolytic cleavage of bacteriophage lambda repressor in induction. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1090931 | PubMed |
| 5 | 282,602 | Chemical synthesis of genes for human insulin. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/282602 | PubMed |
| 6 | 85,300 | Expression in Escherichia coli of chemically synthesized genes for human insulin. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/85300 | PubMed |
| 7 | 1,105,573 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1105573 | PubMed |
| 8 | 344,137 | Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. | Gene | 1977 | https://conductscience.org/library/papers/344137 | PubMed |
| 9 | 340,049 | Maximizing gene expression on a plasmid using recombination in vitro. | Cell | 1978 | https://conductscience.org/library/papers/340049 | PubMed |
| 10 | 358,198 | A bacterial clone synthesizing proinsulin. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/358198 | PubMed |
| 11 | 593,368 | Construction and analysis of recombinant DNA for human chorionic somatomammotropin. | Nature | 1977 | https://conductscience.org/library/papers/593368 | PubMed |
| 12 | 80,751 | Synthesis of an ovalbumin-like protein by Escherichia coli K12 harbouring a recombinant plasmid. | Nature | 1978 | https://conductscience.org/library/papers/80751 | PubMed |
| 13 | 1,069,307 | Construction of plasmids carrying the cI gene of bacteriophage lambda. | Proc Natl Acad Sci U S A | 1976 | https://conductscience.org/library/papers/1069307 | PubMed |
| 14 | 4,205,699 | Intracellular location of newly synthesized growth hormone. | Exp Cell Res | 1973 | https://conductscience.org/library/papers/4205699 | PubMed |
| 15 | 370,836 | A general method for maximizing the expression of a cloned gene. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/370836 | PubMed |
| 16 | 104,296 | Chicken ovalbumin is synthesized and secreted by Escherichia coli. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/104296 | PubMed |
| 18 | 265,521 | A new method for sequencing DNA. | Proc Natl Acad Sci U S A | 1977 | https://conductscience.org/library/papers/265521 | PubMed |
| 19 | 4,599,917 | E. coli lactose operon ribosome binding site. | Nature | 1974 | https://conductscience.org/library/papers/4599917 | PubMed |
| 20 | 4,350,343 | Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex. | J Bacteriol | 1973 | https://conductscience.org/library/papers/4350343 | PubMed |
| 21 | 339,105 | Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. | Nature | 1977 | https://conductscience.org/library/papers/339105 | PubMed |
Cited by82
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 422 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,510,888 | Design, Synthesis, and Proof-of-Concept Bioassay of an Encapsulated mRNA for Human Growth Hormone. | Curr Issues Mol Biol | 2026 | https://conductscience.org/library/papers/42510888 | PubMed |
| 42,232,529 | Adherence to daily growth hormone therapy in Japan: real-world data from the Melon Nikki™ app and device. | J Endocr Soc | 2026 | https://conductscience.org/library/papers/42232529 | PubMed |
| 41,021,200 | History and Current Status of Growth Hormone Treatment in Children. | Paediatr Drugs | 2025 | https://conductscience.org/library/papers/41021200 | PubMed |
| 39,905,169 | Design and regulation of engineered bacteria for environmental release. | Nat Microbiol | 2025 | https://conductscience.org/library/papers/39905169 | PubMed |
| 39,514,089 | Meclozine and growth hormone ameliorate bone length and quality in experimental models of achondroplasia. | J Bone Miner Metab | 2025 | https://conductscience.org/library/papers/39514089 | PubMed |
| 38,488,050 | Rationale for Long-acting Growth Hormone Therapy and Future Aspects | J Clin Res Pediatr Endocrinol | 2025 | https://conductscience.org/library/papers/38488050 | PubMed |
| 36,263,321 | New insight into the importance of formulation variables on parenteral growth hormone preparations: potential effect on the injection-site pain. | Front Endocrinol (Lausanne) | 2022 | https://conductscience.org/library/papers/36263321 | PubMed |
| 35,002,983 | Safety of Pediatric rhGH Therapy: An Overview and the Need for Long-Term Surveillance. | Front Endocrinol (Lausanne) | 2021 | https://conductscience.org/library/papers/35002983 | PubMed |
| 34,956,092 | GH Resistance Is a Component of Idiopathic Short Stature: Implications for rhGH Therapy. | Front Endocrinol (Lausanne) | 2021 | https://conductscience.org/library/papers/34956092 | PubMed |
| 34,342,575 | A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery. | Elife | 2021 | https://conductscience.org/library/papers/34342575 | PubMed |
| 34,290,673 | Human Growth and Growth Hormone: From Antiquity to the Recominant Age to the Future. | Front Endocrinol (Lausanne) | 2021 | https://conductscience.org/library/papers/34290673 | PubMed |
| 33,838,090 | Provocative growth hormone testing in children: how did we get here and where do we go now? | J Pediatr Endocrinol Metab | 2021 | https://conductscience.org/library/papers/33838090 | PubMed |
| 33,543,731 | Growth failure: 'idiopathic' only after a detailed diagnostic evaluation. | Endocr Connect | 2021 | https://conductscience.org/library/papers/33543731 | PubMed |
| 32,735,629 | Structural and functional characterization of recombinant human growth hormone isolated from transgenic pig milk. | PLoS One | 2020 | https://conductscience.org/library/papers/32735629 | PubMed |
| 31,630,114 | Of Molecules and Mechanisms. | J Neurosci | 2020 | https://conductscience.org/library/papers/31630114 | PubMed |
| 29,546,874 | Growth hormone - past, present and future. | Nat Rev Endocrinol | 2018 | https://conductscience.org/library/papers/29546874 | PubMed |
| 29,280,742 | The Rationale for Growth Hormone Therapy in Children with Short Stature. | J Clin Res Pediatr Endocrinol | 2017 | https://conductscience.org/library/papers/29280742 | PubMed |
| 28,515,770 | High level expression of recombinant human growth hormone in Escherichia coli: crucial role of translation initiation region. | Res Pharm Sci | 2017 | https://conductscience.org/library/papers/28515770 | PubMed |
| 27,965,536 | A Tribute to Peter H Seeburg (1944-2016): A Founding Father of Molecular Neurobiology. | Front Mol Neurosci | 2016 | https://conductscience.org/library/papers/27965536 | PubMed |
| 24,983,421 | 2014 Association of American Physicians Presidential Address. Disruptive innovation as a driver of science and medicine. | J Clin Invest | 2014 | https://conductscience.org/library/papers/24983421 | PubMed |
Genes1
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes |
|---|---|---|---|
| GH1 | 2,688 | PubTator's text mining | https://conductscience.org/library/genes/2688 |
Source NCBI Gene
Data2
The data bank entries PubMed's record names. Trial numbers are under Trials.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Grants
- Trials
- Comments and corrections
- Drugs
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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