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Paper · 39401361

The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming.

Paiardi G and 3 others. Proc Natl Acad Sci U S A, 2024. Cited by 13 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming. Papers, record 39401361. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39401361

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
2024
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
13
iCite
Relative citation ratio, by iCite
2.14, provisional
iCite
Revised in PubMed
2026-09-23
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Paiardi GGiuliahttps://orcid.org/0000-0001-6000-0270
2Ferraz MMatheushttps://orcid.org/0000-0002-6958-3115
3Rusnati MMarcohttps://orcid.org/0000-0001-9968-5908
4Wade RCRebecca Chttps://orcid.org/0000-0001-5951-8670

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Spike Glycoprotein, CoronavirusMajor topic
Angiotensin-Converting Enzyme 2Major topic
SARS-CoV-2Major topic
Heparan SulfateMajor topic
Molecular Dynamics SimulationMajor topic
PolysaccharidesMajor topic
Protein BindingMajor topic
Humans
COVID-19
Virus Internalization
Glycosaminoglycans

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
458623378Deutsche Forschungsgemeinschaft (DFG)PubMed
57507871Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References70

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
133,298,900Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro.Cell Discov2020https://conductscience.org/library/papers/33298900PubMed
232,989,130Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.Proc Natl Acad Sci U S A2020https://conductscience.org/library/papers/32989130PubMed
339,401,361The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming.Proc Natl Acad Sci U S A2024https://conductscience.org/library/papers/39401361PubMed
433,189,680The flexibility of ACE2 in the context of SARS-CoV-2 infection.Biophys J2021https://conductscience.org/library/papers/33189680PubMed
515,215,472PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations.Nucleic Acids Res2004https://conductscience.org/library/papers/15215472PubMed
632,225,175Structural basis of receptor recognition by SARS-CoV-2.Nature2020https://conductscience.org/library/papers/32225175PubMed
733,368,089Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.Thromb Haemost2020https://conductscience.org/library/papers/33368089PubMed
834,839,261Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro.EBioMedicine2021https://conductscience.org/library/papers/34839261PubMed
932,366,695Site-specific glycan analysis of the SARS-CoV-2 spike.Science2020https://conductscience.org/library/papers/32366695PubMed
1032,929,138Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition.Sci Rep2020https://conductscience.org/library/papers/32929138PubMed

1 to 10 of 70

See all 70 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 13 citations.

PMIDTitleJournalYearIn PapersSource
42,555,109Site-specific and global glycan analysis of the human cytomegalovirus pentameric glycoprotein by high resolution mass spectrometry.Glycobiology2026https://conductscience.org/library/papers/42555109PubMed
42,146,132Antiviral Activity of Dendritic Heparan Sulfate Mimetics against Respiratory Syncytial Virus and Herpes Simplex Virus‑1.ACS Omega2026https://conductscience.org/library/papers/42146132PubMed
41,536,137Glycans Modulate the Adsorption of RBD Glycoproteins on Polarizable Surfaces.J Chem Inf Model2026https://conductscience.org/library/papers/41536137PubMed
41,516,274Natural Fatty Acids as Dual ACE2-Inflammatory Modulators: Integrated Computational Framework for Pandemic Preparedness.Int J Mol Sci2025https://conductscience.org/library/papers/41516274PubMed
41,513,808K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming.Npj Viruses2026https://conductscience.org/library/papers/41513808PubMed
41,277,840
The glycosylation variant at residue 381 of the spike protein contributes to virulence shifts in porcine epidemic diarrhea virus during both natural field transmission and laboratory cell passaging with poor cross-protection.
J Virol2025https://conductscience.org/library/papers/41277840PubMed
41,008,650Interaction Between Heparan Sulfate Oligosaccharide and the Receptor-Binding Domain of the Wild-Type and Omicron Variant of the SARS-CoV-2 Spike Protein.Biomolecules2025https://conductscience.org/library/papers/41008650PubMed
40,358,361Identification of an Unnatural Sulfated Monosaccharide as a High-Affinity Ligand for Pan-Variant Targeting of SARS-CoV-2 Spike Glycoprotein.ACS Chem Biol2025https://conductscience.org/library/papers/40358361PubMed
39,886,596Quantitative Prediction of Protein-Polyelectrolyte Binding Thermodynamics: Adsorption of Heparin-Analog Polysulfates to the SARS-CoV-2 Spike Protein RBD.JACS Au2025https://conductscience.org/library/papers/39886596PubMed
39,401,361The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming.Proc Natl Acad Sci U S A2024https://conductscience.org/library/papers/39401361PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
ACE259,272PubTator's text mininghttps://conductscience.org/library/genes/59272

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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