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Paper · 39505261

Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells.

Moliterni C and 14 others. J Lipid Res, 2024. Cited by 29 papers, by iCite.

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ConductScience Library. Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells. Papers, record 39505261. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39505261

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells.
PubMed
Journal
J Lipid Res
PubMed
Year
2024
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
29
iCite
Relative citation ratio, by iCite
4.94, provisional
iCite
Revised in PubMed
2026-06-06
PubMed

Authors15

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Moliterni CCamilla
2Vari FFrancesco
3Schifano EEmily
4Tacconi SStefano
5Stanca EEleonora
6Friuli MMarzia
7Longo SSerena
8Conte MMaria
9Salvioli SStefano
10Gnocchi DDavide

1 to 10 of 15Source PubMed

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Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Diacylglycerol O-AcyltransferaseMajor topic
Palmitic AcidMajor topic
PPAR alphaMajor topic
Down-RegulationMajor topic
Endoplasmic Reticulum StressMajor topic
AutophagyMajor topic
Humans
Liver
Hepatocytes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References74

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
139,187,042Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models.J Lipid Res2024https://conductscience.org/library/papers/39187042PubMed
230,523,332Dynamics and functions of lipid droplets.Nat Rev Mol Cell Biol2019https://conductscience.org/library/papers/30523332PubMed
339,275,168Palmitic Acid Induces Oxidative Stress and Senescence in Human Brainstem Astrocytes, Downregulating Glutamate Reuptake Transporters-Implications for Obesity-Related Sympathoexcitation.Nutrients2024https://conductscience.org/library/papers/39275168PubMed
434,869,541Differential Effects of Oleic and Palmitic Acids on Lipid Droplet-Mitochondria Interaction in the Hepatic Cell Line HepG2.Front Nutr2021https://conductscience.org/library/papers/34869541PubMed
518,757,836Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.J Lipid Res2008https://conductscience.org/library/papers/18757836PubMed
632,917,959Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases.Exp Mol Med2020https://conductscience.org/library/papers/32917959PubMed
721,476,911Autophagy in nonalcoholic steatohepatitis.Expert Rev Gastroenterol Hepatol2011https://conductscience.org/library/papers/21476911PubMed
838,329,230Oleic acid differentially affects lipid droplet storage of de novo synthesized lipids in hepatocytes and adipocytes.Chem Commun (Camb)2024https://conductscience.org/library/papers/38329230PubMed
929,902,571Diacylglycerol acyltransferase-2 contains a c-terminal sequence that interacts with lipid droplets.Biochim Biophys Acta Mol Cell Biol Lipids2018https://conductscience.org/library/papers/29902571PubMed
1031,937,853Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism.Sci Rep2020https://conductscience.org/library/papers/31937853PubMed

1 to 10 of 74

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 29 citations.

PMIDTitleJournalYearIn PapersSource
42,882,471Distinct OA:PA Ratios Generate Discrete Hepatocellular Phenotypes in HepG2 Cells.Cells2026https://conductscience.org/library/papers/42882471PubMed
42,418,595Optical photothermal infrared imaging of fatty acid esterification in the ER of living cells.Sci Adv2026https://conductscience.org/library/papers/42418595PubMed
42,397,153Physiologically relevant media are associated with overlapping metabolic responses in primary human hepatocytes and Huh7 cells.Physiol Rep2026https://conductscience.org/library/papers/42397153PubMed
42,347,037Regulated Cell Death in Fungi, the Role of Metacaspases and Assay Techniques.Methods Protoc2026https://conductscience.org/library/papers/42347037PubMed
42,278,667Beyond Glucose: Palmitic Acid Influences VEGFA-VEGFR2 Angiogenic Signaling in Müller Glial Cells.Int J Mol Sci2026https://conductscience.org/library/papers/42278667PubMed
42,278,345An Aqueous Extract of Beta vulgaris subsp. Vulgaris Beetroot Group Reduces Lipid Accumulation in Human Keratinocyte Cells.Int J Mol Sci2026https://conductscience.org/library/papers/42278345PubMed
41,928,358Chronic kidney disease induces a distinct lipidomic signature and accelerates atherosclerosis progression in a novel minipig model.Lab Anim Res2026https://conductscience.org/library/papers/41928358PubMed
41,901,255GLP-1 RAs for Treating Metabolic Dysfunction-Associated Steatosis Liver Disease: From GLP-1 Discovery to FDA Approval: A Comprehensive Narrative Review.Pharmaceuticals (Basel)2026https://conductscience.org/library/papers/41901255PubMed
41,898,462Restoring Mitochondrial Homeostasis: Therapeutic Strategies for Metabolic Dysfunction-Associated Fatty Liver Disease.Int J Mol Sci2026https://conductscience.org/library/papers/41898462PubMed
41,831,570Epithelial-Mesenchymal Transition Shapes the Lipotoxic Response of Colon Cancer Cells to Palmitic Acid.Mol Cell Proteomics2026https://conductscience.org/library/papers/41831570PubMed

1 to 10 of 22

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
DGAT18,694PubTator's text mininghttps://conductscience.org/library/genes/8694NCBI Gene
PPARA5,465PubTator's text mininghttps://conductscience.org/library/genes/5465NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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