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Paper · 39506152

Coordinated inheritance of extrachromosomal DNAs in cancer cells.

Hung KL and 24 others. Nature, 2024. Cited by 88 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Coordinated inheritance of extrachromosomal DNAs in cancer cells. Papers, record 39506152. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39506152

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Coordinated inheritance of extrachromosomal DNAs in cancer cells.
PubMed
Journal
Nature
PubMed
Year
2024
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
88
iCite
Relative citation ratio, by iCite
8.11, provisional
iCite
Revised in PubMed
2026-11-02
PubMed

Authors25

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Hung KLKing Lhttps://orcid.org/0000-0002-3662-4662
2Jones MGMatthew G
3Wong ITIvy Tsz-Lohttps://orcid.org/0000-0002-9761-3422
4Curtis EJEllis J
5Lange JTJoshua T
6He BJBritney Jiayuhttps://orcid.org/0000-0001-8989-1521
7Luebeck JJenshttps://orcid.org/0000-0003-4391-979X
8Schmargon RRachelhttps://orcid.org/0009-0009-3535-7185
9Scanu EElisa
10Brückner LLottehttps://orcid.org/0000-0002-6155-2277

1 to 10 of 25Source PubMed

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Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Extrachromosomal InheritanceMajor topic
MitosisMajor topic
NeoplasmsMajor topic
DNAMajor topic
Humans
Cell Line, Tumor
Epigenesis, Genetic
Gene Dosage
Models, Genetic
Oncogenes
Single-Cell Analysis
Transcription, Genetic

Source PubMed

Grants12

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
K99 CA286968NCI NIH HHSUnited StatesK99CA286968PubMed and NIHNIH RePORTER
U24 CA264379NCI NIH HHSUnited StatesU24CA264379PubMed and NIHNIH RePORTER
CGCATF-2021/100012Cancer Research UKUnited KingdomPubMedPubMed
OT2 CA278635NCI NIH HHSUnited StatesOT2CA278635PubMed and NIHNIH RePORTER
R01 GM114362NIGMS NIH HHSUnited StatesR01GM114362PubMed and NIHNIH RePORTER
F99CA274692NIHNIH RePORTER
OT2CA278644NIHNIH RePORTER
OT2CA278670NIHNIH RePORTER
OT2CA278688NIHNIH RePORTER
OT2CA278692NIHNIH RePORTER

1 to 10 of 12

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Update of37,503,111Coordinated inheritance of extrachromosomal DNA species in human cancer cells.https://conductscience.org/library/papers/37503111

Source PubMed

References65

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
138,409,389Extrachromosomal DNA in cancer.Nat Rev Cancer2024https://conductscience.org/library/papers/38409389PubMed
234,819,668ecDNA hubs drive cooperative intermolecular oncogene expression.Nature2021https://conductscience.org/library/papers/34819668PubMed
328,178,237Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.Nature2017https://conductscience.org/library/papers/28178237PubMed
434,680,928Gene Amplification and the Extrachromosomal Circular DNA.Genes (Basel)2021https://conductscience.org/library/papers/34680928PubMed
53,856,243Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3856243PubMed
624,310,612Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.Science2014https://conductscience.org/library/papers/24310612PubMed
7903,253Experimental elimination and recovery of double minute chromosomes in malignant cell populations.Hereditas1977https://conductscience.org/library/papers/903253PubMed
829,686,388Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma.Nat Genet2018https://conductscience.org/library/papers/29686388PubMed
9649,427Have double minutes functioning centromeres?Hereditas1978https://conductscience.org/library/papers/649427PubMed
1018,769,732Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.PLoS One2008https://conductscience.org/library/papers/18769732PubMed

1 to 10 of 65

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Cited by70

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 88 citations.

PMIDTitleJournalYearIn PapersSource
42,897,892Profiling Extrachromosomal Circular DNA (ecDNA) in Cancer via Next-Generation Sequencing: A New Frontier in Tumor Evolution and Therapy Resistance.Anticancer Agents Med Chem2026https://conductscience.org/library/papers/42897892PubMed
42,888,240AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes.Nat Methods2026https://conductscience.org/library/papers/42888240PubMed
42,864,499Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival.Nat Genet2026https://conductscience.org/library/papers/42864499PubMed
42,827,107Single-cell epigenomics of colorectal cancer.Exp Mol Med2026https://conductscience.org/library/papers/42827107PubMed
42,826,715An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events.Mol Cell2026https://conductscience.org/library/papers/42826715PubMed
42,818,635Quantitative and sensitive neuroblastoma minimal residual disease detection using extrachromosomal DNA (ecDNA) breakpoints.bioRxiv2026https://conductscience.org/library/papers/42818635PubMed
42,816,857Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Mol Cancer2026https://conductscience.org/library/papers/42816857PubMed
42,778,593MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness.Nature2026https://conductscience.org/library/papers/42778593PubMed
42,736,483The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nat Rev Genet2026https://conductscience.org/library/papers/42736483PubMed
42,706,270scAmp enables focal gene amplification analysis from single-cell data.Nat Commun2026https://conductscience.org/library/papers/42706270PubMed

1 to 10 of 70

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE159986

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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