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Paper · 34680928

Gene Amplification and the Extrachromosomal Circular DNA.

Shimizu N. Genes (Basel), 2021. Cited by 26 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Gene Amplification and the Extrachromosomal Circular DNA. Papers, record 34680928. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34680928

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Gene Amplification and the Extrachromosomal Circular DNA.
PubMed
Journal
Genes (Basel)
PubMed
Year
2021
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
26
iCite
Relative citation ratio, by iCite
1.31
iCite
Revised in PubMed
2022-02-08
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Shimizu NNoriaki

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA, CircularMajor topic
Gene AmplificationMajor topic
NeoplasmsMajor topic
Animals
Chromothripsis
Humans

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References72

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,528,254Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA.Nat Genet1996https://conductscience.org/library/papers/8528254PubMed
229,540,679Circular DNA elements of chromosomal origin are common in healthy human somatic tissue.Nat Commun2018https://conductscience.org/library/papers/29540679PubMed
330,399,332Rotten to the Core: Why Micronuclei Rupture.Dev Cell2018https://conductscience.org/library/papers/30399332PubMed
431,041,889Generation and maintenance of acentric stable double minutes from chromosome arms in inter-species hybrid cells.BMC Mol Cell Biol2019https://conductscience.org/library/papers/31041889PubMed
516,269,822Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material.Nucleic Acids Res2005https://conductscience.org/library/papers/16269822PubMed
612,724,318Enrichment for histone H3 lysine 9 methylation at Alu repeats in human cells.J Biol Chem2003https://conductscience.org/library/papers/12724318PubMed
717,606,478Micronuclei bearing acentric extrachromosomal chromatin are transcriptionally competent and may perturb the cancer cell phenotype.Mol Cancer Res2007https://conductscience.org/library/papers/17606478PubMed
831,900,366Identification and characterization of extrachromosomal circular DNA in maternal plasma.Proc Natl Acad Sci U S A2020https://conductscience.org/library/papers/31900366PubMed
929,686,388Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma.Nat Genet2018https://conductscience.org/library/papers/29686388PubMed
102,079,966Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells.Mutat Res1990https://conductscience.org/library/papers/2079966PubMed

1 to 10 of 72

See all 72 references

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 26 citations.

PMIDTitleJournalYearIn PapersSource
42,897,892Profiling Extrachromosomal Circular DNA (ecDNA) in Cancer via Next-Generation Sequencing: A New Frontier in Tumor Evolution and Therapy Resistance.Anticancer Agents Med Chem2026https://conductscience.org/library/papers/42897892PubMed
42,646,941Baseline Frequency of Chromosomal Aberrations in Control Donors: A Significant Value for Population Monitoring During the Development of the Nuclear Energy Industry-Polish Dataset.Toxics2026https://conductscience.org/library/papers/42646941PubMed
42,037,670KCTD10 as a selective cancer dependency from transcription-replication conflicts (TRCs).Ageing Cancer Res Treat2026https://conductscience.org/library/papers/42037670PubMed
41,947,008Galectin-9high Neutrophils Exacerbate Radiation-Induced Frailty.Aging Cell2026https://conductscience.org/library/papers/41947008PubMed
41,634,401Targeting extrachromosomal DNA in human cancers.Nat Rev Drug Discov2026https://conductscience.org/library/papers/41634401PubMed
41,533,581Optimized CRISPR-Cas9 system for efficient engineering of ecDNA in cancer cells.Nucleic Acids Res2026https://conductscience.org/library/papers/41533581PubMed
41,482,934The newfound relationship between extrachromosomal DNAs and excised signal circles.FEBS Lett2026https://conductscience.org/library/papers/41482934PubMed
39,969,664Extrachromosomal circular DNA: a double-edged sword in cancer progression and age-related diseases.Hum Cell2025https://conductscience.org/library/papers/39969664PubMed
39,707,444Unveiling the mysteries of extrachromosomal circular DNA: from generation to clinical relevance in human cancers and health.Mol Cancer2024https://conductscience.org/library/papers/39707444PubMed
39,506,152Coordinated inheritance of extrachromosomal DNAs in cancer cells.Nature2024https://conductscience.org/library/papers/39506152PubMed

1 to 10 of 20

See all 20 cited by

Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CGAS115,004PubTator's text mininghttps://conductscience.org/library/genes/115004NCBI Gene
HBB3,043PubTator's text mininghttps://conductscience.org/library/genes/3043NCBI Gene
MYC4,609PubTator's text mininghttps://conductscience.org/library/genes/4609NCBI Gene
MYH1479,784PubTator's text mininghttps://conductscience.org/library/genes/79784NCBI Gene
SIRT123,411PubTator's text mininghttps://conductscience.org/library/genes/23411NCBI Gene
STING1340,061PubTator's text mininghttps://conductscience.org/library/genes/340061NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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