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Paper · 28178237

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.

Turner KM and 20 others. Nature, 2017. Cited by 662 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Papers, record 28178237. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28178237

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.
PubMed
Journal
Nature
PubMed
Year
2017
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
662
iCite
Relative citation ratio, by iCite
17.1
iCite
Revised in PubMed
2024-06-10
PubMed

Authors21

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Turner KMKristen M
2Deshpande VViraj
3Beyter DDoruk
4Koga TTomoyuki
5Rusert JJessica
6Lee CCatherine
7Li BBin
8Arden KKaren
9Ren BBing
10Nathanson DADavid A

1 to 10 of 21Source PubMed

See all 21 authors

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA Copy Number VariationsMajor topic
Evolution, MolecularMajor topic
Gene AmplificationMajor topic
Genetic HeterogeneityMajor topic
Models, GeneticMajor topic
NeoplasmsMajor topic
OncogenesMajor topic
Chromosomes, Human
Cytogenetic Analysis
DNA Mutational Analysis
Genome, Human
Humans
Metaphase
RNA, Messenger
RNA, Neoplasm
Reproducibility of Results
Software

Source PubMed

Grants8

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
T32 CA121938NCI NIH HHSUnited StatesT32CA121938PubMed and NIHNIH RePORTER
U54 CA151819NCI NIH HHSUnited StatesU54CA151819PubMed and NIHNIH RePORTER
R01 GM114362NIGMS NIH HHSUnited StatesR01GM114362PubMed and NIHNIH RePORTER
R01 NS080939NINDS NIH HHSUnited StatesR01NS080939PubMed and NIHNIH RePORTER
R56 NS080939NINDS NIH HHSUnited StatesR01NS080939PubMed and NIHNIH RePORTER
P30 CA014195NCI NIH HHSUnited StatesP30CA014195PubMed and NIHNIH RePORTER
R01 CA159859NCI NIH HHSUnited StatesR01CA159859PubMed and NIHNIH RePORTER
R01 NS073831NINDS NIH HHSUnited StatesR01NS073831PubMed and NIHNIH RePORTER

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT05827614Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene AmplificationsBackground

Source ClinicalTrials.gov

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in28,239,156Cancer genomics: ECdetect hunts extrachromosomal DNA.https://conductscience.org/library/papers/28239156

Source PubMed

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,513,401Intra-tumour heterogeneity: a looking glass for cancer?Nat Rev Cancer2012https://conductscience.org/library/papers/22513401PubMed
221,107,781Frequency of double minute chromosomes and combined cytogenetic abnormalities and their characteristics.J Appl Genet2011https://conductscience.org/library/papers/21107781PubMed
33,164,477Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.Proc Natl Acad Sci U S A1988https://conductscience.org/library/papers/3164477PubMed
425,517,748The architecture and evolution of cancer neochromosomes.Cancer Cell2014https://conductscience.org/library/papers/25517748PubMed
56,378,386Gene amplification in cultured animal cells.Cell1984https://conductscience.org/library/papers/6378386PubMed
623,940,299Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons.Cancer Res2013https://conductscience.org/library/papers/23940299PubMed
712,045,153The human genome browser at UCSC.Genome Res2002https://conductscience.org/library/papers/12045153PubMed
822,258,609Clonal evolution in cancer.Nature2012https://conductscience.org/library/papers/22258609PubMed
926,618,723Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.Nat Med2016https://conductscience.org/library/papers/26618723PubMed
10715,457Gene amplification and drug resistance in cultured murine cells.Science1978https://conductscience.org/library/papers/715457PubMed

1 to 10 of 32

See all 32 references

Cited by523

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 662 citations.

PMIDTitleJournalYearIn PapersSource
42,958,602Glioblastoma as a dynamic tumor ecosystem: from molecular alterations to therapeutic translation.Exp Hematol Oncol2026https://conductscience.org/library/papers/42958602PubMed
42,953,000Extrachromosomal circular DNA drives focal amplification of AGAP2-AS1 to promote cutaneous tumorigenesis.Front Pharmacol2026https://conductscience.org/library/papers/42953000PubMed
42,897,892Profiling Extrachromosomal Circular DNA (ecDNA) in Cancer via Next-Generation Sequencing: A New Frontier in Tumor Evolution and Therapy Resistance.Anticancer Agents Med Chem2026https://conductscience.org/library/papers/42897892PubMed
42,888,240AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes.Nat Methods2026https://conductscience.org/library/papers/42888240PubMed
42,875,653Reframing cancer therapy through tumor plasticity.Nat Cancer2026https://conductscience.org/library/papers/42875653PubMed
42,842,575The dynamics of gene copy-number mutations: transient changes with long-lasting consequences.Genetics2026https://conductscience.org/library/papers/42842575PubMed
42,826,715An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events.Mol Cell2026https://conductscience.org/library/papers/42826715PubMed
42,816,857Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Mol Cancer2026https://conductscience.org/library/papers/42816857PubMed
42,791,387Unraveling the lexicon of complex mutational phenomena in human cancers.Nat Cancer2026https://conductscience.org/library/papers/42791387PubMed
42,778,593MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness.Nature2026https://conductscience.org/library/papers/42778593PubMed

1 to 10 of 523

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Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CCND1595PubTator's text mininghttps://conductscience.org/library/genes/595NCBI Gene
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
ERBB22,064PubTator's text mininghttps://conductscience.org/library/genes/2064NCBI Gene
HSR338,386PubTator's text mininghttps://conductscience.org/library/genes/338386NCBI Gene
MRAP56,246PubTator's text mininghttps://conductscience.org/library/genes/56246NCBI Gene
MYC4,609PubTator's text mininghttps://conductscience.org/library/genes/4609NCBI Gene
RNASE16,035PubTator's text mininghttps://conductscience.org/library/genes/6035NCBI Gene
SRPRA6,734PubTator's text mininghttps://conductscience.org/library/genes/6734NCBI Gene
TXK7,294PubTator's text mininghttps://conductscience.org/library/genes/7294NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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