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Paper · 39751699

Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway.

Chen L and 7 others. Hum Cell, 2025. Cited by 5 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway. Papers, record 39751699. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39751699

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway.
PubMed
Journal
Hum Cell
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
5
iCite
Relative citation ratio, by iCite
1.33, provisional
iCite
Revised in PubMed
2026-11-01
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chen LLin
2Gao YYongjian
3Yang HHuaixi
4Su YYanzhuo
5Zhang YYunxin
6Lou LLin
7Wang XXuefeng
8Ding DDayong

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gastrointestinal Stromal TumorsMajor topic
Imatinib MesylateMajor topic
Drug Resistance, NeoplasmMajor topic
RNA, Long NoncodingMajor topic
Proto-Oncogene Proteins c-aktMajor topic
Signal TransductionMajor topic
Humans
Phosphatidylinositol 3-Kinases
Antineoplastic Agents
Gastrointestinal Neoplasms
Cell Line, Tumor
Fibronectins
Gene Expression
MicroRNAs
Microfilament Proteins
Up-Regulation
Phosphatidylinositol 3-Kinase

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
20200201586JCNatural Science Foundation of Jilin ProvincePubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
133,625,998Expression of lncRNA MSC-AS1 in hepatocellular carcinoma cell lines and its effect on proliferation, apoptosis, and migration.Turk J Gastroenterol2020https://conductscience.org/library/papers/33625998PubMed
235,255,438Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells.Biochem Biophys Res Commun2022https://conductscience.org/library/papers/35255438PubMed
335,358,540CTCF-activated SNHG16 facilitates gastrointestinal stromal tumor by targeting miR-128-3p/CASC3 axis.Exp Cell Res2022https://conductscience.org/library/papers/35358540PubMed
436,890,211Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.Cancer Gene Ther2023https://conductscience.org/library/papers/36890211PubMed
529,423,012CCDC26 knockdown enhances resistance of gastrointestinal stromal tumor cells to imatinib by interacting with c-KIT.Am J Transl Res2018https://conductscience.org/library/papers/29423012PubMed
624,297,251starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.Nucleic Acids Res2014https://conductscience.org/library/papers/24297251PubMed
733,899,120The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway.Mol Med Rep2021https://conductscience.org/library/papers/33899120PubMed
838,173,514Dysregulated ANLN reveals immune cell landscape and promotes carcinogenesis by regulating the PI3K/Akt/mTOR pathway in clear cell renal cell carcinoma.Heliyon2024https://conductscience.org/library/papers/38173514PubMed
931,749,661Identification of upstream miRNAs of SNAI2 and their influence on the metastasis of gastrointestinal stromal tumors.Cancer Cell Int2019https://conductscience.org/library/papers/31749661PubMed
1032,708,220The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors.Int J Mol Sci2020https://conductscience.org/library/papers/32708220PubMed

1 to 10 of 33

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Cited by5

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 5 citations.

PMIDTitleJournalYearIn PapersSource
42,653,297Non-Coding RNAs in Gastrointestinal Stromal Tumors: Regulatory Networks, Drug Resistance, and Clinical Implications.Int J Mol Sci2026https://conductscience.org/library/papers/42653297PubMed
41,939,436Targeted Therapy for Advanced Gastrointestinal Stromal Tumors: Evolution and Future Directions.Drug Des Devel Ther2026https://conductscience.org/library/papers/41939436PubMed
41,573,677The role of ANLN in malignant tumors: pathogenesis, treatment resistance and targeted strategies.Front Cell Dev Biol2025https://conductscience.org/library/papers/41573677PubMed
40,965,063The Roles, Mechanisms, and Clinical Significance of Long Non-coding RNA MSC-AS1 in Cancer.Mini Rev Med Chem2025https://conductscience.org/library/papers/40965063PubMed
40,205,068LINC01559: roles, mechanisms, and clinical implications in human cancers.Hum Cell2025https://conductscience.org/library/papers/40205068PubMed

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
ANLN54,443PubTator's text mininghttps://conductscience.org/library/genes/54443NCBI Gene
FNDC184,624PubTator's text mininghttps://conductscience.org/library/genes/84624NCBI Gene
MSC-AS1100,132,891PubTator's text mininghttps://conductscience.org/library/genes/100132891NCBI Gene
PIK3R15,295PubTator's text mininghttps://conductscience.org/library/genes/5295NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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