Paper · 40312745
Puerarin relives inflammation, bone destruction and facilitates osteogenic differentiation in periodontitis by enhancing mitochondrial autophagy via activating mitochondrial Mitofusin 2.
Xiang Y and 8 others. Stem Cell Res Ther, 2025. Cited by 6 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Puerarin relives inflammation, bone destruction and facilitates osteogenic differentiation in periodontitis by enhancing mitochondrial autophagy via activating mitochondrial Mitofusin 2. Papers, record 40312745. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40312745
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Puerarin relives inflammation, bone destruction and facilitates osteogenic differentiation in periodontitis by enhancing mitochondrial autophagy via activating mitochondrial Mitofusin 2.
- PubMed
Topics17
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Isoflavones | Major topic |
| Periodontitis | Major topic |
| Mitochondria | Major topic |
| Osteogenesis | Major topic |
| Autophagy | Major topic |
| Inflammation | Major topic |
| GTP Phosphohydrolases | Major topic |
| Mitochondrial Proteins | Major topic |
| Animals | |
| Mice | |
| Humans | |
| Mice, Inbred C57BL | |
| Cell Differentiation | |
| Porphyromonas gingivalis | |
| Male | |
| Periodontal Ligament | |
| Reactive Oxygen Species |
Source PubMed
Grants3
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by |
|---|---|---|---|---|
| 2024GR056 | the China Higher Education Innovation Fund | PubMed | ||
| 2024-2-2143 | the Capital's Funds for Health Improvement and Research | PubMed | ||
| Nos20230484404 | Beijing Nova Program | PubMed |
Source PubMed
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References42
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 31,820,522 | Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway. | Cell Prolif | 2020 | https://conductscience.org/library/papers/31820522 | PubMed |
| 2 | 38,246,334 | Mitochondrial dynamics and mitochondrial autophagy: Molecular structure, orchestrating mechanism and related disorders. | Mitochondrion | 2024 | https://conductscience.org/library/papers/38246334 | PubMed |
| 3 | 33,583,561 | Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions. | Biol Psychiatry | 2021 | https://conductscience.org/library/papers/33583561 | PubMed |
| 4 | 36,416,316 | Regulation of reactive oxygen species on the mitophagy of human periodontal ligament cells through the PINK1/Parkin pathway under starvation. | Hua Xi Kou Qiang Yi Xue Za Zhi | 2022 | https://conductscience.org/library/papers/36416316 | PubMed |
| 5 | 35,413,643 | Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy. | Redox Biol | 2022 | https://conductscience.org/library/papers/35413643 | PubMed |
| 6 | 37,833,824 | Effects of tension on mitochondrial autophagy and osteogenic differentiation of periodontal ligament stem cells. | Cell Prolif | 2024 | https://conductscience.org/library/papers/37833824 | PubMed |
| 7 | 30,046,371 | Mitofusin2 Induces Cell Autophagy of Pancreatic Cancer through Inhibiting the PI3K/Akt/mTOR Signaling Pathway. | Oxid Med Cell Longev | 2018 | https://conductscience.org/library/papers/30046371 | PubMed |
| 8 | 35,902,802 | Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage. | Cell Mol Biol Lett | 2022 | https://conductscience.org/library/papers/35902802 | PubMed |
| 9 | 35,730,318 | PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages. | Oral Dis | 2023 | https://conductscience.org/library/papers/35730318 | PubMed |
| 10 | 30,218,100 | An experimental murine model to study periodontitis. | Nat Protoc | 2018 | https://conductscience.org/library/papers/30218100 | PubMed |
1 to 10 of 42
See all 42 referencesCited by6
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,582,789 | Molecular Mechanisms and Therapeutic Potential of Puerariae Lobatae Radix in Bone Metabolism: A Comprehensive Review. | Drug Des Devel Ther | 2026 | https://conductscience.org/library/papers/42582789 | PubMed |
| 42,573,918 | Puerarin alleviates inflammation and promotes osteogenic differentiation in periodontitis: insights from autophagy and Notch signaling pathway. | Odontology | 2026 | https://conductscience.org/library/papers/42573918 | PubMed |
| 42,368,455 | Traditional Chinese medicine-derived monomers improve bone metabolic imbalance and delay osteoporosis progression by regulating mitochondrial homeostasis. | Front Cell Dev Biol | 2026 | https://conductscience.org/library/papers/42368455 | PubMed |
| 41,909,100 | Periodontitis Phenotypes and Treatment Outcomes Following Combined Periodontal and Orthodontic Therapy: A Cohort Study. | Clin Cosmet Investig Dent | 2026 | https://conductscience.org/library/papers/41909100 | PubMed |
| 41,281,645 | Ultra-small coordination dihydromyricetin nanodots attenuate alveolar bone resorption in periodontitis through inhibition of ITGB3-Driven osteoclast differentiation. | Mater Today Bio | 2025 | https://conductscience.org/library/papers/41281645 | PubMed |
| 40,728,722 | An emerging role of mitochondrial quality control in bone metabolism: from molecular mechanisms to targeted therapeutic interventions. | Cell Mol Life Sci | 2025 | https://conductscience.org/library/papers/40728722 | PubMed |
Genes0
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
None in this release.
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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