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Paper · 35902802

Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage.

Li J and 9 others. Cell Mol Biol Lett, 2022. Cited by 96 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage. Papers, record 35902802. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35902802

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage.
PubMed
Journal
Cell Mol Biol Lett
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
96
iCite
Relative citation ratio, by iCite
8.76
iCite
Revised in PubMed
2026-01-27
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Li JJin
2Jiang MMengqing
3Yu ZZhentang
4Xiong CChenwei
5Pan JJieen
6Cai ZZhenhai
7Xu NNanwei
8Zhou XXindiehttps://orcid.org/0000-0001-6194-6308
9Huang YYong
10Yang ZZhicheng

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ArtemisininsMajor topic
Cartilage, ArticularMajor topic
OsteoarthritisMajor topic
Animals
Autophagy
Chondrocytes
Interleukin-1beta
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
RANK Ligand
Rats
Signal Transduction
TOR Serine-Threonine Kinases

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
CJ20210104Changzhou Sci&Tech ProgramPubMed
CZQM2020059Young Talent Development Plan of Changzhou Health CommissionPubMed
2020KY313Zhejiang Medicine and Health Technology PlanPubMed
2020AY30020Jiaxing Science and Technology ProjectPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References51

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,539,107Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.Bone2008https://conductscience.org/library/papers/18539107PubMed
230,453,055Osteoarthritis year in review 2018: clinical.Osteoarthritis Cartilage2019https://conductscience.org/library/papers/30453055PubMed
321,205,641Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.Science2011https://conductscience.org/library/papers/21205641PubMed
428,294,321Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo.J Cell Physiol2018https://conductscience.org/library/papers/28294321PubMed
533,613,618The Efficacy and Safety of the mTOR Signaling Pathway Activator, MHY1485, for in vitro Activation of Human Ovarian Tissue.Front Genet2020https://conductscience.org/library/papers/33613618PubMed
631,546,898Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis.Int J Mol Sci2019https://conductscience.org/library/papers/31546898PubMed
722,210,913RANKL induces organized lymph node growth by stromal cell proliferation.J Immunol2012https://conductscience.org/library/papers/22210913PubMed
832,266,056Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours.Cell Biosci2020https://conductscience.org/library/papers/32266056PubMed
931,126,594
An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).
Semin Arthritis Rheum2019https://conductscience.org/library/papers/31126594PubMed
1021,931,183Hormesis, cell death and aging.Aging (Albany NY)2011https://conductscience.org/library/papers/21931183PubMed

1 to 10 of 51

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Cited by61

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 96 citations.

PMIDTitleJournalYearIn PapersSource
42,839,683A serum proteomics-based predictive model for steroid-resistant immune checkpoint inhibitor associated myocarditis.Clin Transl Med2026https://conductscience.org/library/papers/42839683PubMed
42,687,185ROS-responsive injectable hydrogel enables controlled release of human adipose tissue-derived extracellular vesicles for multifaceted osteoarthritis therapy.J Nanobiotechnology2026https://conductscience.org/library/papers/42687185PubMed
42,577,500New therapeutic target for osteoarthritis: modulating immune-metabolic aberrations and micromilieu remodeling in underlying bone.Front Pharmacol2026https://conductscience.org/library/papers/42577500PubMed
42,440,180A Combination of Artemisinin, N-acetylcysteine, Resveratrol, and Hesperidin Ameliorates Hippocampal Damage and Pathological Features in an Experimental Model of Alzheimer's Disease.Neurochem Res2026https://conductscience.org/library/papers/42440180PubMed
42,437,187Astragaloside IV Alleviates Osteoarthritis by Upregulating ETS2: A Bioinformatics and Experimental Study.J Inflamm Res2026https://conductscience.org/library/papers/42437187PubMed
42,424,009TRIM65 accelerates VSMC-derived foam cell formation and arteriosclerosis progression by inhibiting mitophagy.Mol Cell Biochem2026https://conductscience.org/library/papers/42424009PubMed
42,287,035Integrative Multiomics and Network Pharmacology Exploration of Active Components and Mechanisms of Action of Qufu Shengxin Ointment in Treating Chronic Nonhealing Wounds.Mediators Inflamm2026https://conductscience.org/library/papers/42287035PubMed
42,245,479Traditional Chinese medicine-derived monomers delay osteoarthritis progression by regulating mitochondrial homeostasis.Front Cell Dev Biol2026https://conductscience.org/library/papers/42245479PubMed
42,220,285Research progress on cellular senescence in the pathogenesis and treatment of osteoarthritis and temporomandibular joint osteoarthritis.J Oral Facial Pain Headache2026https://conductscience.org/library/papers/42220285PubMed
42,145,974Modulation of Neuronal Mitochondrial Injury by Gualou Guizhi Decoction in a Mouse Ischemia-Reperfusion Model.Iran J Biotechnol2026https://conductscience.org/library/papers/42145974PubMed

1 to 10 of 61

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Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
MMP134,322PubTator's text mininghttps://conductscience.org/library/genes/4322NCBI Gene
MMP74,316PubTator's text mininghttps://conductscience.org/library/genes/4316NCBI Gene
MMP94,318PubTator's text mininghttps://conductscience.org/library/genes/4318NCBI Gene
PTGS25,743PubTator's text mininghttps://conductscience.org/library/genes/5743NCBI Gene
TNFRSF11B4,982PubTator's text mininghttps://conductscience.org/library/genes/4982NCBI Gene
TNFSF118,600PubTator's text mininghttps://conductscience.org/library/genes/8600NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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