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Paper · 31820522

Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway.

Zhou J and 4 others. Cell Prolif, 2020. Cited by 256 papers, by iCite. Retracted.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway. Papers, record 31820522. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31820522

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway.
PubMed
Journal
Cell Prolif
PubMed
Year
2020
PubMed
Publication types
Journal Article, Retracted Publication
PubMed
Citations, by iCite
256
iCite
Relative citation ratio, by iCite
13.8
iCite
Retracted
Yes, by PubMed's record
PubMed
Revised in PubMed
2026-01-27
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zhou JJin
2Jiang YYYuan-Yuan
3Chen HHuan
4Wu YCYi-Chao
5Zhang LLihttps://orcid.org/0000-0003-2196-2180

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AbietanesMajor topic
ApoptosisMajor topic
AutophagyMajor topic
Ovarian NeoplasmsMajor topic
Phosphatidylinositol 3-KinasesMajor topic
Proto-Oncogene Proteins c-aktMajor topic
TOR Serine-Threonine KinasesMajor topic
Animals
Antineoplastic Agents, Phytogenic
Caspase 3
Cell Line, Tumor
Cell Proliferation
Cell Survival
Female
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Signal Transduction
Xenograft Model Antitumor Assays

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
2019YFS0021Sichuan Science and Technology ProgramPubMed
2018TJPT0013Sichuan Science and Technology ProgramPubMed
2016NYZ0036Sichuan Crops and Animals Breeding Special ProjectPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Retracted by39,443,824RETRACTION: Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway.https://conductscience.org/library/papers/39443824

Source PubMed

References55

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
124,333,502Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway.Pharmacol Ther2014https://conductscience.org/library/papers/24333502PubMed
219,001,436Anticancer effects of tanshinone I in human non-small cell lung cancer.Mol Cancer Ther2008https://conductscience.org/library/papers/19001436PubMed
326,283,590Blockade of TNF-α-induced NF-κB signaling pathway and anti-cancer therapeutic response of dihydrotanshinone I.Int Immunopharmacol2015https://conductscience.org/library/papers/26283590PubMed
426,583,091PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy.Biomed Res Int2015https://conductscience.org/library/papers/26583091PubMed
528,306,502Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17.Mol Cell2017https://conductscience.org/library/papers/28306502PubMed
616,955,220Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells.J Neurooncol2007https://conductscience.org/library/papers/16955220PubMed
725,619,832Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.Oncogene2015https://conductscience.org/library/papers/25619832PubMed
825,482,988PLC and PI3K/Akt/mTOR signalling in disease and cancer.Adv Biol Regul2015https://conductscience.org/library/papers/25482988PubMed
929,891,531Autophagy in cancer: a complex relationship.Biochem J2018https://conductscience.org/library/papers/29891531PubMed
1025,257,169Autosis and autophagic cell death: the dark side of autophagy.Cell Death Differ2015https://conductscience.org/library/papers/25257169PubMed

1 to 10 of 55

See all 55 references

Cited by165

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 256 citations.

PMIDTitleJournalYearIn PapersSource
42,979,277Role of PI3K/Akt/mTOR signaling in the therapeutic effects of Fuzheng Lishi Huayu Decoction on persistent Chlamydia trachomatis infection.J Tradit Complement Med2026https://conductscience.org/library/papers/42979277PubMed
42,656,404Targeting RSF1 with tanshinone I inhibits cervical cancer cell growth through modulation of NF-κB pathway.Front Pharmacol2026https://conductscience.org/library/papers/42656404PubMed
42,298,679A review of PI3K/AKT/mTOR inhibitors from traditional Chinese medicine: potential and perspective for activated phosphoinositide 3-kinase δ syndrome.Orphanet J Rare Dis2026https://conductscience.org/library/papers/42298679PubMed
42,224,092WDR72 Drives Esophageal Squamous Cell Carcinoma Progression by Inhibiting Autophagy via the PI3K/Akt/mTOR Pathway.Kaohsiung J Med Sci2026https://conductscience.org/library/papers/42224092PubMed
42,095,894SETDB1 induces H3K9me3 methylation modification of RASSF2 to inhibit PTEN and facilitate ovarian cancer progression.Mol Genet Genomics2026https://conductscience.org/library/papers/42095894PubMed
41,929,250Therapeutic functions of tanshinone IIA in a zebrafish model of glucocorticoid-induced osteoporosis.Front Pharmacol2026https://conductscience.org/library/papers/41929250PubMed
41,852,887Apoptotic body-encapsulated zinc-doped Salvia miltiorrhiza carbon dots trigger PANoptosis for targeted therapy of hepatocellular carcinoma.Mater Today Bio2026https://conductscience.org/library/papers/41852887PubMed
41,571,749Upregulated miR-204-5p inhibits oral squamous cell carcinoma progression via inducing autophagy-promoted apoptosis by targeting PIK3CB.Sci Rep2026https://conductscience.org/library/papers/41571749PubMed
41,511,607Tanshinone I Promotes Ferroptosis of Cervical Cancer Cells by Activating the ATF3-Mediated Transcriptional Inhibition of FSP1.Appl Biochem Biotechnol2026https://conductscience.org/library/papers/41511607PubMed
41,399,788Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.Chin Herb Med2025https://conductscience.org/library/papers/41399788PubMed

1 to 10 of 165

See all 165 cited by

Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
ATG710,533PubTator's text mininghttps://conductscience.org/library/genes/10533NCBI Gene
BECN18,678PubTator's text mininghttps://conductscience.org/library/genes/8678NCBI Gene
CASP3836PubTator's text mininghttps://conductscience.org/library/genes/836NCBI Gene
CCND1595PubTator's text mininghttps://conductscience.org/library/genes/595NCBI Gene
H3P16644,914PubTator's text mininghttps://conductscience.org/library/genes/644914NCBI Gene
MAP1LC3A84,557PubTator's text mininghttps://conductscience.org/library/genes/84557NCBI Gene
MTOR2,475PubTator's text mininghttps://conductscience.org/library/genes/2475NCBI Gene
NUP6223,636PubTator's text mininghttps://conductscience.org/library/genes/23636NCBI Gene
STAT36,774PubTator's text mininghttps://conductscience.org/library/genes/6774NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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