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Paper · 40469445

The evolution of the therapeutic concept 'GIP receptor antagonism'.

Koefoed-Hansen F and 5 others. Front Endocrinol (Lausanne), 2025. Cited by 9 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The evolution of the therapeutic concept 'GIP receptor antagonism'. Papers, record 40469445. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40469445

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The evolution of the therapeutic concept 'GIP receptor antagonism'.
PubMed
Journal
Front Endocrinol (Lausanne)
PubMed
Year
2025
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
9
iCite
Relative citation ratio, by iCite
2.35, provisional
iCite
Revised in PubMed
2025-06-07
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Koefoed-Hansen FFrederikke
2Helsted MMMads Marstrand
3Kizilkaya HSHüsün Sheyma
4Lund ABAsger Bach
5Rosenkilde MMMette Marie
6Gasbjerg LSLærke Smidt

Source PubMed

Topics4

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Receptors, Gastrointestinal HormoneMajor topic
Gastric Inhibitory PolypeptideMajor topic
Humans
Animals

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References119

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
128,237,651GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release.Biochem Pharmacol2017https://conductscience.org/library/papers/28237651PubMed
227,186,353Alternative form of glucose-dependent insulinotropic polypepide and its physiology.J Diabetes Investig2016https://conductscience.org/library/papers/27186353PubMed
34,749,457Stimulation of insulin secretion by gastric inhibitory polypeptide in man.J Clin Endocrinol Metab1973https://conductscience.org/library/papers/4749457PubMed
436,509,857Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1.Nat Rev Endocrinol2023https://conductscience.org/library/papers/36509857PubMed
536,400,403Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems.Mol Metab2022https://conductscience.org/library/papers/36400403PubMed
621,593,115Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans.J Clin Endocrinol Metab2011https://conductscience.org/library/papers/21593115PubMed
722,522,617Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.Diabetes2012https://conductscience.org/library/papers/22522617PubMed
824,446,656A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk.J Clin Endocrinol Metab2014https://conductscience.org/library/papers/24446656PubMed
929,378,179Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors.Biochem Pharmacol2018https://conductscience.org/library/papers/29378179PubMed
1034,210,852Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.Science2021https://conductscience.org/library/papers/34210852PubMed

1 to 10 of 119

See all 119 references

Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 9 citations.

PMIDTitleJournalYearIn PapersSource
42,603,240Effect of tirzepatide and semaglutide on blood pressure: A systematic review and meta-analysis.Endocrine2026https://conductscience.org/library/papers/42603240PubMed
42,525,756Altered Gi signaling in enteroendocrine K cells in vivo causes pronounced changes in glucose homeostasis.Sci Adv2026https://conductscience.org/library/papers/42525756PubMed
42,373,095Reproducibility of Splanchnic Blood Flow Measured Using Phase-Contrast MRI.NMR Biomed2026https://conductscience.org/library/papers/42373095PubMed
42,307,179The evolving therapeutic landscape of gut-pancreatic peptide signalling in metabolic disorders: from mono- to multi-agonist therapies.Biosci Rep2026https://conductscience.org/library/papers/42307179PubMed
41,973,737Clinical Potential of GIP in Type 2 Diabetes and Obesity.Diabetes Care2026https://conductscience.org/library/papers/41973737PubMed
41,596,254The Role of Glucose-Dependent Insulinotropic Polypeptide (GIP) in Bone Metabolism.Int J Mol Sci2026https://conductscience.org/library/papers/41596254PubMed
40,943,066Recent Updates on Diabetes and Bone.Int J Mol Sci2025https://conductscience.org/library/papers/40943066PubMed

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GIP2,695PubTator's text mininghttps://conductscience.org/library/genes/2695NCBI Gene
GLP1R2,740PubTator's text mininghttps://conductscience.org/library/genes/2740NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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