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Paper · 40499006

Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm.

Oliveira EA and 19 others. Cancer Res, 2025. Cited by 34 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm. Papers, record 40499006. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40499006

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm.
PubMed
Journal
Cancer Res
PubMed
Year
2025
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
34
iCite
Relative citation ratio, by iCite
7.37, provisional
iCite
Revised in PubMed
2026-07-22
PubMed

Authors20

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Oliveira EAErica Ahttps://orcid.org/0000-0002-1624-4021
2Milite SSalvatorehttps://orcid.org/0000-0002-0156-3636
3Fernandez-Mateos JJavierhttps://orcid.org/0000-0002-4949-4131
4Cresswell GDGeorge Dhttps://orcid.org/0000-0003-3303-068X
5Yara-Romero EErikahttps://orcid.org/0009-0002-7557-9128
6Vlachogiannis GGeorgioshttps://orcid.org/0000-0003-3114-8772
7Chen BBingjiehttps://orcid.org/0000-0001-7689-2146
8James CTChela Thttps://orcid.org/0000-0003-3996-0909
9Patruno LLucreziahttps://orcid.org/0000-0002-3721-9984
10Ascolani GGianlucahttps://orcid.org/0000-0001-5501-3368

1 to 10 of 20Source PubMed

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Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Drug Resistance, NeoplasmMajor topic
Cell PlasticityMajor topic
Epigenesis, GeneticMajor topic
Colorectal NeoplasmsMajor topic
Humans
Phenotype
Genotype
Organoids
Clonal Evolution
Gene Expression Regulation, Neoplastic

Source PubMed

Grants14

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
A19771Cancer Research UK (CRUK)PubMed
A18052Cancer Research UK (CRUK)PubMed
28961Fondazione AIRC per la ricerca sul cancro ETS (AIRC)PubMed
22790Fondazione AIRC per la ricerca sul cancro ETS (AIRC)PubMed
21091Fondazione AIRC per la ricerca sul cancro ETS (AIRC)PubMed
A26815Cancer Research UK (CRUK)PubMed
CIG 334261NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research (BRC)PubMed
24913Fondazione AIRC per la ricerca sul cancro ETS (AIRC)PubMed
202778/Z/16/ZWellcome Trust (WT)PubMed
202778/B/16/ZWellcome Trust (WT)PubMed

1 to 10 of 14Source PubMed

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References66

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
136,289,335The co-evolution of the genome and epigenome in colorectal cancer.Nature2022https://conductscience.org/library/papers/36289335PubMed
234,594,037Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.Nat Genet2021https://conductscience.org/library/papers/34594037PubMed
334,062,119Integrated analysis of multimodal single-cell data.Cell2021https://conductscience.org/library/papers/34062119PubMed
434,531,319Epigenetic Alterations and Mechanisms That Drive Resistance to Targeted Cancer Therapies.Cancer Res2021https://conductscience.org/library/papers/34531319PubMed
531,831,859Principles and mechanisms of non-genetic resistance in cancer.Br J Cancer2020https://conductscience.org/library/papers/31831859PubMed
621,430,269Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors.Sci Transl Med2011https://conductscience.org/library/papers/21430269PubMed
728,607,484Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance.Nature2017https://conductscience.org/library/papers/28607484PubMed
836,699,385decoupleR: ensemble of computational methods to infer biological activities from omics data.Bioinform Adv2022https://conductscience.org/library/papers/36699385PubMed
919,451,168Fast and accurate short read alignment with Burrows-Wheeler transform.Bioinformatics2009https://conductscience.org/library/papers/19451168PubMed
1019,487,300Adaptive therapy.Cancer Res2009https://conductscience.org/library/papers/19487300PubMed

1 to 10 of 66

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Cited by36

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 34 citations.

PMIDTitleJournalYearIn PapersSource
42,972,057The genomic and epigenomic evolution of colorectal cancer.Nat Rev Gastroenterol Hepatol2026https://conductscience.org/library/papers/42972057PubMed
42,966,755Conformational heterogeneity: a fundamental mechanism of adaptive phenotypic plasticity and therapeutic resistance.Br J Cancer2026https://conductscience.org/library/papers/42966755PubMed
42,928,367The memory of the tumor microenvironment: epigenetic scarring and the hysteretic logic of therapeutic relapse.Oncogene2026https://conductscience.org/library/papers/42928367PubMed
42,923,094Epigenetic adaptations and vulnerabilities in ovarian cancer drug-tolerant persister cells.NAR Cancer2026https://conductscience.org/library/papers/42923094PubMed
42,902,326Cancer metastasis: biological mechanisms, therapeutic bottlenecks, and emerging interventions.J Hematol Oncol2026https://conductscience.org/library/papers/42902326PubMed
42,875,653Reframing cancer therapy through tumor plasticity.Nat Cancer2026https://conductscience.org/library/papers/42875653PubMed
42,778,549Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42778549PubMed
42,724,856Drug-tolerant persister cells use conserved adaptive transcriptional programs.Transl Cancer Res2026https://conductscience.org/library/papers/42724856PubMed
42,717,056A guide to understanding tumour evolution through the lens of population genetics.Nat Rev Cancer2026https://conductscience.org/library/papers/42717056PubMed
42,711,452A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nat Rev Cancer2026https://conductscience.org/library/papers/42711452PubMed

1 to 10 of 36

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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