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Paper410022

Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.

Farr AG and 2 others. Proc Natl Acad Sci U S A, 1977. Cited by 82 papers, by iCite.

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ConductScience Library. Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex. Papers, record 410022. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/410022

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
82
iCite
Relative citation ratio, by iCite
1.91
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Farr AGA G
2Dorf MEM E
3Unanue ERE R

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Histocompatibility AntigensMajor topic
MacrophagesMajor topic
T-LymphocytesMajor topic
Animals
Female
Genes
Listeria monocytogenes
Listeriosis
Male
Mice
Mice, Inbred Strains
Mitogens
Species Specificity
Thymidine

Source PubMed

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,467,923Cellular resistance to infection.J Exp Med1962https://conductscience.org/library/papers/14467923PubMed
267,177H-2 restriction of cell-mediated immunity to an intracellular bacterium: effector T cells are specific for Listeria antigen in association with H-21 region-coded self-markers.J Exp Med1977https://conductscience.org/library/papers/67177PubMed
3140,194Thymic maturation in vitro by a secretory product from macrophages.J Immunol1977https://conductscience.org/library/papers/140194PubMed
4320,663Functional specificity of thymus- dependent lymphocytes.Science1977https://conductscience.org/library/papers/320663PubMed
54,126,770Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.J Exp Med1973https://conductscience.org/library/papers/4126770PubMed
64,129,963Cell-mediated immunity to bacterial infection in the mouse. Thymus-derived cells as effectors of acquired resistance to Listeria monocytogenes.Scand J Immunol1972https://conductscience.org/library/papers/4129963PubMed
74,216,017An inhibitor of cell proliferation released by cultures of macrophages.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4216017PubMed
858,463Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.Transplant Rev1976https://conductscience.org/library/papers/58463PubMed
958,458Role of the murine major histocompatibility complex in the specificity of in vitro T-cell-mediated lympholysis against chemically-modified autologous lymphocytes.Transplant Rev1976https://conductscience.org/library/papers/58458PubMed
104,623,315Requirement of thymus (T) lymphocytes for resistance to listeriosis.J Exp Med1972https://conductscience.org/library/papers/4623315PubMed
1155,461Specific binding of alloantigens to T cells activated in the mixed lymphocyte reaction.J Exp Med1976https://conductscience.org/library/papers/55461PubMed
1247,901
H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.
J Exp Med1975https://conductscience.org/library/papers/47901PubMed
134,549,027Potentiation of the T lymphocyte response to mitogens. III. Properties of the mediator(s) from adherent cells.Cell Immunol1974https://conductscience.org/library/papers/4549027PubMed
145,033,418Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).J Exp Med1972https://conductscience.org/library/papers/5033418PubMed
15809,532Inhibition of T-lymphocyte-mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor.J Exp Med1975https://conductscience.org/library/papers/809532PubMed
161,097,572The modulation of lymphocyte functions by molecules secreted by macrophages. I. Description and partial biochemical analysis.J Exp Med1975https://conductscience.org/library/papers/1097572PubMed
171,093,892Macrophage-lymphocyte interaction and antigen recognition.Fed Proc1975https://conductscience.org/library/papers/1093892PubMed
181,084,997Role of major histocompatibility complex gene products in delayed-type hypersensitivity.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1084997PubMed
191,084,402The modulation of lymphocyte functions by molecules secreted by macrophages. II. Conditions leading to increased secretion.J Exp Med1976https://conductscience.org/library/papers/1084402PubMed
201,090,698Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.J Exp Med1975https://conductscience.org/library/papers/1090698PubMed

See all 23 references

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 82 citations.

PMIDTitleJournalYearIn PapersSource
22,457,929Activation or suppression of bactericidal activity of macrophages during a graft-versus-host reaction against I-A and I-J-region differences, respectively.Immunogenetics1980https://conductscience.org/library/papers/22457929PubMed
16,106,079Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?Immunol Res2005https://conductscience.org/library/papers/16106079PubMed
6,981,816Interleukin 1 can replace the requirement for I-A-positive cells in the proliferation of antigen-primed T cells.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6981816PubMed
6,969,776Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages.J Exp Med1980https://conductscience.org/library/papers/6969776PubMed
6,929,512During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6929512PubMed
6,804,386Ontogeny of murine macrophages: functions related to antigen presentation.Infect Immun1982https://conductscience.org/library/papers/6804386PubMed
6,369,329Mutational specificity of depurination.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6369329PubMed
6,332,170Purification and partial biochemical characterization of normal human interleukin 1.J Exp Med1984https://conductscience.org/library/papers/6332170PubMed
3,517,219Immunocytochemical detection of interleukin 1 within stimulated human monocytes.J Exp Med1986https://conductscience.org/library/papers/3517219PubMed
3,464,353Immunoregulating activity of tumor-associated macrophages.Cancer Immunol Immunother1986https://conductscience.org/library/papers/3464353PubMed
3,155,862Two separate functions of class II (Ia) molecules: T-cell stimulation and B-cell excitation.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3155862PubMed
3,138,184The role of T cell subpopulations in cell mediated immunity to facultative intracellular bacteria.Infection1988https://conductscience.org/library/papers/3138184PubMed
3,100,876Functional characteristics of human alveolar macrophages in lung cancer.Lung1986https://conductscience.org/library/papers/3100876PubMed
2,969,373T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired immunity.Infect Immun1988https://conductscience.org/library/papers/2969373PubMed
2,931,359L3T4 but not LFA-1 participates in antigen presentation by Ak-positive L-cell transformants.Immunogenetics1985https://conductscience.org/library/papers/2931359PubMed
359,748Alteration of some functional and metabolic characteristics of resident mouse peritoneal macrophages by lymphocyte mediators.J Exp Med1978https://conductscience.org/library/papers/359748PubMed
314,491Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen.J Exp Med1979https://conductscience.org/library/papers/314491PubMed
159,416A defect in the antigen-presenting function of macrophages from neonatal mice.Nature1979https://conductscience.org/library/papers/159416PubMed
115,958The specific binding of Listeria monocytogenes-immune T lymphocytes to macrophages. I. Quantitation and role of H-2 gene products.J Exp Med1979https://conductscience.org/library/papers/115958PubMed
91,174Thymus-derived lymphocytes control the expression of immunogenic properties of peritoneal macrophages.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/91174PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Genes
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Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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