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Paper · 41348890

Steric disruption of EGFR oligomerization overcomes therapy resistance in non-small cell lung cancer.

Song D and 3 others. Sci Adv, 2025. Cited by 2 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Steric disruption of EGFR oligomerization overcomes therapy resistance in non-small cell lung cancer. Papers, record 41348890. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41348890

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Steric disruption of EGFR oligomerization overcomes therapy resistance in non-small cell lung cancer.
PubMed
Journal
Sci Adv
PubMed
Year
2025
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
2
iCite
Revised in PubMed
2026-08-05
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Song DDaesunhttps://orcid.org/0000-0002-6206-2034
2Jang JJaebong
3Lin MZMichael Zhttps://orcid.org/0000-0002-0492-1961
4Jung YYongwonhttps://orcid.org/0000-0002-1034-9797

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carcinoma, Non-Small-Cell LungMajor topic
ErbB ReceptorsMajor topic
Drug Resistance, NeoplasmMajor topic
Lung NeoplasmsMajor topic
Protein MultimerizationMajor topic
Humans
Protein Kinase Inhibitors
Mutation
Cell Line, Tumor
Cell Proliferation
Signal Transduction

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R21 GM132687NIGMS NIH HHSUnited StatesR21GM132687PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References54

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
136,344,833Chemically stable fluorescent proteins for advanced microscopy.Nat Methods2022https://conductscience.org/library/papers/36344833PubMed
222,452,895Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial.Lancet Oncol2012https://conductscience.org/library/papers/22452895PubMed
324,063,894Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.Cancer Res2013https://conductscience.org/library/papers/24063894PubMed
437,350,862Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review.RSC Adv2023https://conductscience.org/library/papers/37350862PubMed
525,985,220The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells.ACS Synth Biol2015https://conductscience.org/library/papers/25985220PubMed
62,590,944Structure of the Drosophila BicaudalD protein and its role in localizing the posterior determinant nanos.Cell1989https://conductscience.org/library/papers/2590944PubMed
723,959,269Targeted therapies: Afatinib--new therapy option for EGFR-mutant lung cancer.Nat Rev Clin Oncol2013https://conductscience.org/library/papers/23959269PubMed
826,609,494EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII).Am J Cancer Res2015https://conductscience.org/library/papers/26609494PubMed
927,017,828Molecular basis for multimerization in the activation of the epidermal growth factor receptor.Elife2016https://conductscience.org/library/papers/27017828PubMed
1024,019,492Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.Proc Natl Acad Sci U S A2013https://conductscience.org/library/papers/24019492PubMed

1 to 10 of 54

See all 54 references

Cited by2

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2 citations.

PMIDTitleJournalYearIn PapersSource
41,882,712MicroRNA-regulated signaling and tumor microenvironment modulation in lung cancer: mechanistic insights and translational opportunities.Cancer Cell Int2026https://conductscience.org/library/papers/41882712PubMed
41,690,169Optimization of ultrasound-assisted extraction of Sargassum polycystum for antitumor activity: Multi-objective optimization and mechanistic insights.Ultrason Sonochem2026https://conductscience.org/library/papers/41690169PubMed

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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