Paper · 27017828
Molecular basis for multimerization in the activation of the epidermal growth factor receptor.
Huang Y and 9 others. Elife, 2016. Cited by 150 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Molecular basis for multimerization in the activation of the epidermal growth factor receptor. Papers, record 27017828. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/27017828
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Molecular basis for multimerization in the activation of the epidermal growth factor receptor.
- PubMed
Topics12
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| ErbB Receptors | Major topic |
| Protein Multimerization | Major topic |
| Allosteric Regulation | |
| Animals | |
| DNA Mutational Analysis | |
| Mutant Proteins | |
| Oocytes | |
| Phosphatidylinositol 3-Kinase | |
| Phosphorylation | |
| Protein Processing, Post-Translational | |
| Single Molecule Imaging | |
| Xenopus |
Source PubMed
Grants3
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| R01 CA096504 | NCI NIH HHS | United States | R01CA096504 | PubMed and NIH | NIH RePORTER |
| R01 GM117051 | NIGMS NIH HHS | United States | R01GM117051 | PubMed and NIH | NIH RePORTER |
| R15 EY024451 | NEI NIH HHS | United States | R15EY024451 | PubMed and NIH | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References80
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 16,107,719 | Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface. | Mol Cell Biol | 2005 | https://conductscience.org/library/papers/16107719 | PubMed |
| 2 | 23,996,272 | How good is automated protein docking? | Proteins | 2013 | https://conductscience.org/library/papers/23996272 | PubMed |
| 3 | 26,337,388 | Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer. | Mol Biol Cell | 2015 | https://conductscience.org/library/papers/26337388 | PubMed |
| 4 | 12,297,049 | Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. | Cell | 2002 | https://conductscience.org/library/papers/12297049 | PubMed |
| 5 | 7,518,560 | Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. | Mol Cell Biol | 1994 | https://conductscience.org/library/papers/7518560 | PubMed |
| 6 | 19,079,236 | The unfolded protein response signals through high-order assembly of Ire1. | Nature | 2009 | https://conductscience.org/library/papers/19079236 | PubMed |
| 7 | 12,461,170 | A putative molecular-activation switch in the transmembrane domain of erbB2. | Proc Natl Acad Sci U S A | 2002 | https://conductscience.org/library/papers/12461170 | PubMed |
| 8 | 16,200,636 | The Amber biomolecular simulation programs. | J Comput Chem | 2005 | https://conductscience.org/library/papers/16200636 | PubMed |
| 9 | 9,029,149 | Two EGF molecules contribute additively to stabilization of the EGFR dimer. | EMBO J | 1997 | https://conductscience.org/library/papers/9029149 | PubMed |
| 10 | 26,621,095 | The MARTINI Coarse-Grained Force Field: Extension to Proteins. | J Chem Theory Comput | 2008 | https://conductscience.org/library/papers/26621095 | PubMed |
1 to 10 of 80
See all 80 referencesCited by109
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 150 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,789,702 | Synthetic FLS2 receptor oligomer boosts plant innate immunity. | Sci Adv | 2026 | https://conductscience.org/library/papers/42789702 | PubMed |
| 42,717,534 | Structural Basis of Lymphangiogenic Receptor VEGFR-3 Activation Mediated by Distinctive Clustering of the Ligand-Receptor Complex. | Adv Sci (Weinh) | 2026 | https://conductscience.org/library/papers/42717534 | PubMed |
| 42,248,463 | Differential ErbB receptor dimerization modulates the ability of EGF receptor ligands to regulate metabolic flux. | J Biol Chem | 2026 | https://conductscience.org/library/papers/42248463 | PubMed |
| 42,018,692 | Quantitative Mapping of Nanoscale EGFR-Grb2 Assemblies by DNA-PAINT. | Chemphyschem | 2026 | https://conductscience.org/library/papers/42018692 | PubMed |
| 41,894,539 | Microproteins in Human Physiology and Pathology. | Biochemistry | 2026 | https://conductscience.org/library/papers/41894539 | PubMed |
| 41,817,402 | Tetraspanin CD82 shapes EGFR signaling outcomes through nanoscale receptor organization. | J Cell Biol | 2026 | https://conductscience.org/library/papers/41817402 | PubMed |
| 41,632,257 | Quantitative Stimulated Emission Depletion (STED) Microscopy with DNA-Fluorophore Labels. | ACS Nano | 2026 | https://conductscience.org/library/papers/41632257 | PubMed |
| 41,410,773 | Emergent eukaryotic directional sensing via receptor degradation and diffusion. | Proc Natl Acad Sci U S A | 2025 | https://conductscience.org/library/papers/41410773 | PubMed |
| 41,348,890 | Steric disruption of EGFR oligomerization overcomes therapy resistance in non-small cell lung cancer. | Sci Adv | 2025 | https://conductscience.org/library/papers/41348890 | PubMed |
| 41,319,267 | Surface-Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF-β Signaling in a Contact-Dependent Manner. | Adv Sci (Weinh) | 2026 | https://conductscience.org/library/papers/41319267 | PubMed |
1 to 10 of 109
See all 109 cited byGenes19
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CLDN16 | 10,686 | PubTator's text mining | https://conductscience.org/library/genes/10686 | NCBI Gene |
| CLEC3B | 7,123 | PubTator's text mining | https://conductscience.org/library/genes/7123 | NCBI Gene |
| EGF | 1,950 | PubTator's text mining | https://conductscience.org/library/genes/1950 | NCBI Gene |
| EGFR | 1,956 | PubTator's text mining | https://conductscience.org/library/genes/1956 | NCBI Gene |
| ERBB2 | 2,064 | PubTator's text mining | https://conductscience.org/library/genes/2064 | NCBI Gene |
| ERBB3 | 2,065 | PubTator's text mining | https://conductscience.org/library/genes/2065 | NCBI Gene |
| ERBB4 | 2,066 | PubTator's text mining | https://conductscience.org/library/genes/2066 | NCBI Gene |
| ERN1 | 2,081 | PubTator's text mining | https://conductscience.org/library/genes/2081 | NCBI Gene |
| GRB2 | 2,885 | PubTator's text mining | https://conductscience.org/library/genes/2885 | NCBI Gene |
| MAPK1 | 5,594 | PubTator's text mining | https://conductscience.org/library/genes/5594 | NCBI Gene |
1 to 10 of 19
See all 19 genesDrugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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