ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 41398702

The Notch signaling pathway in regulating bone and cartilage homeostasis: novel insights into the pathogenesis and therapeutics of osteoarthritis.

Wang H and 4 others. Cell Commun Signal, 2025. Cited by 6 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. The Notch signaling pathway in regulating bone and cartilage homeostasis: novel insights into the pathogenesis and therapeutics of osteoarthritis. Papers, record 41398702. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41398702

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The Notch signaling pathway in regulating bone and cartilage homeostasis: novel insights into the pathogenesis and therapeutics of osteoarthritis.
PubMed
Journal
Cell Commun Signal
PubMed
Year
2025
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
6
iCite
Relative citation ratio, by iCite
1.88, provisional
iCite
Revised in PubMed
2026-01-23
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Wang HHaixiahttps://orcid.org/0000-0001-9789-997X
2Li MMinghttps://orcid.org/0000-0002-7841-4911
3Wang XXiaodonghttps://orcid.org/0009-0006-5098-1734
4Han JJuanjuanhttps://orcid.org/0000-0002-0915-6218
5Zhang XAXin-Anhttps://orcid.org/0000-0002-7854-4134

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
OsteoarthritisMajor topic
Receptors, NotchMajor topic
Signal TransductionMajor topic
HomeostasisMajor topic
Bone and BonesMajor topic
CartilageMajor topic
Humans
Animals

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
32371184National Natural Science Foundation of ChinaPubMedPubMed
2024YFC3607304National Key Research and Development Program of ChinaPubMedPubMed
JYTZD2023131Basic scientific research project of higher education institutions of Liaoning ProvinceJYTZD202313PubMedNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References197

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
126,851,274Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis.Ann Rheum Dis2016https://conductscience.org/library/papers/26851274PubMed
233,333,049Nimbolide exerts protective effects in complete Freund's adjuvant induced inflammatory arthritis via abrogation of STAT-3/NF-κB/Notch-1 signaling.Life Sci2021https://conductscience.org/library/papers/33333049PubMed
316,023,595Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.Cancer Cell2005https://conductscience.org/library/papers/16023595PubMed
434,348,968Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity.Cancer Res2021https://conductscience.org/library/papers/34348968PubMed
520,175,978In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model.Osteoarthritis Cartilage2010https://conductscience.org/library/papers/20175978PubMed
639,973,340eIF5A downregulated by mechanical overloading delays chondrocyte senescence and osteoarthritis by regulating the CREBBP-mediated Notch pathway.Bone Joint Res2025https://conductscience.org/library/papers/39973340PubMed
726,558,140Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.Bone Res2015https://conductscience.org/library/papers/26558140PubMed
835,865,541Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions.Front Immunol2022https://conductscience.org/library/papers/35865541PubMed
936,537,124circFOXK2 promotes the progression of osteoarthritis by regulating the miR-4640-5p/NOTCH2 axis.Mod Rheumatol2024https://conductscience.org/library/papers/36537124PubMed
1021,869,831Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation.Cell Death Differ2012https://conductscience.org/library/papers/21869831PubMed

1 to 10 of 197

See all 197 references

Cited by5

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.

PMIDTitleJournalYearIn PapersSource
42,828,103Intensity-dependent microcurrent stimulation enhances BMSC-derived cartilage microtissue formation under defined culture conditions.Mater Today Bio2026https://conductscience.org/library/papers/42828103PubMed
42,769,654Role of Notch signaling pathway in joint homeostasis and osteoarthritis.Front Bioeng Biotechnol2026https://conductscience.org/library/papers/42769654PubMed
42,695,425Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review).Int J Mol Med2026https://conductscience.org/library/papers/42695425PubMed
42,505,419Pharmacological Targeting of Type H Endothelial Cells in Knee Osteoarthritis: From Molecular Signaling to Cellular Homeostasis.Cells2026https://conductscience.org/library/papers/42505419PubMed
42,437,285Tendon stem/progenitor cells in heterotopic ossification: functional regulation, molecular mechanisms and targeted therapeutic strategies.J Orthop Translat2026https://conductscience.org/library/papers/42437285PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/41398702

GET https://conductscience.org/api/papers/v1/41398702/references?page=2

API referenceFor AI assistants