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Paper · 26558140

Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.

Kohn A and 6 others. Bone Res, 2015. Cited by 41 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9. Papers, record 26558140. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/26558140

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.
PubMed
Journal
Bone Res
PubMed
Year
2015
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
41
iCite
Relative citation ratio, by iCite
1.37
iCite
Revised in PubMed
2020-09-30
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kohn AAnat
2Rutkowski TPTimothy P
3Liu ZZhaoyang
4Mirando AJAnthony J
5Zuscik MJMichael J
6O'Keefe RJRegis J
7Hilton MJMatthew J

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 AR063071NIAMS NIH HHSUnited StatesR01AR063071PubMed and NIHNIH RePORTER
T32 AR053459NIAMS NIH HHSUnited StatesT32AR053459PubMedNIH RePORTER
P50 AR054041NIAMS NIH HHSUnited StatesP50AR054041PubMed and NIHNIH RePORTER
P30 AR061307NIAMS NIH HHSUnited StatesP30AR061307PubMedNIH RePORTER
R01 AR057022NIAMS NIH HHSUnited StatesR01AR057022PubMedNIH RePORTER
R21 AR059733NIAMS NIH HHSUnited StatesR21AR059733PubMedNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,141,219Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.Development2005https://conductscience.org/library/papers/16141219PubMed
216,203,988Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/16203988PubMed
36,165,088Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S.Teratology1980https://conductscience.org/library/papers/6165088PubMed
412,112,875Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer.Genesis2002https://conductscience.org/library/papers/12112875PubMed
510,319,868Sox9 is required for cartilage formation.Nat Genet1999https://conductscience.org/library/papers/10319868PubMed
68,001,137Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.Cell1994https://conductscience.org/library/papers/8001137PubMed
718,297,083Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.Nat Med2008https://conductscience.org/library/papers/18297083PubMed
821,594,584Unraveling the transcriptional regulatory machinery in chondrogenesis.J Bone Miner Metab2011https://conductscience.org/library/papers/21594584PubMed
922,991,339Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9.J Bone Miner Res2013https://conductscience.org/library/papers/22991339PubMed
1019,520,195NOTCHing the bone: insights into multi-functionality.Bone2010https://conductscience.org/library/papers/19520195PubMed

1 to 10 of 38

See all 38 references

Cited by29

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 41 citations.

PMIDTitleJournalYearIn PapersSource
42,769,654Role of Notch signaling pathway in joint homeostasis and osteoarthritis.Front Bioeng Biotechnol2026https://conductscience.org/library/papers/42769654PubMed
42,464,284Dynamin inhibitor dynasore modulates longitudinal bone growth in a hormetic manner.BMC Biol2026https://conductscience.org/library/papers/42464284PubMed
41,424,615Innovative tissue engineering strategies for auricular regeneration in microtia: Current advances and future perspectives.Regen Ther2025https://conductscience.org/library/papers/41424615PubMed
41,398,702The Notch signaling pathway in regulating bone and cartilage homeostasis: novel insights into the pathogenesis and therapeutics of osteoarthritis.Cell Commun Signal2025https://conductscience.org/library/papers/41398702PubMed
40,433,419JAG2: A Potential Biomarker for Microtia Identified by Integrated RNA Transcriptome Analysis.Curr Genomics2025https://conductscience.org/library/papers/40433419PubMed
38,523,677Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases.Genes Dis2024https://conductscience.org/library/papers/38523677PubMed
37,794,006MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling.Nat Commun2023https://conductscience.org/library/papers/37794006PubMed
37,485,234Hypertrophic chondrocytes at the junction of musculoskeletal structures.Bone Rep2023https://conductscience.org/library/papers/37485234PubMed
35,185,477Müller Glia in Retinal Development: From Specification to Circuit Integration.Front Neural Circuits2021https://conductscience.org/library/papers/35185477PubMed
34,021,911SOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes.J Pathol2021https://conductscience.org/library/papers/34021911PubMed

1 to 10 of 29

See all 29 cited by

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BMP1649PubTator's text mininghttps://conductscience.org/library/genes/649NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
RBPJ3,516PubTator's text mininghttps://conductscience.org/library/genes/3516NCBI Gene
SOX96,662PubTator's text mininghttps://conductscience.org/library/genes/6662NCBI Gene
TGFB17,040PubTator's text mininghttps://conductscience.org/library/genes/7040NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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