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Paper · 41449430

Role of TREM2 in neuroinflammation regulation: mechanisms, disease associations, and therapeutic translation advances.

Liao Y and 4 others. J Transl Med, 2025. Cited by 6 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Role of TREM2 in neuroinflammation regulation: mechanisms, disease associations, and therapeutic translation advances. Papers, record 41449430. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41449430

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Role of TREM2 in neuroinflammation regulation: mechanisms, disease associations, and therapeutic translation advances.
PubMed
Journal
J Transl Med
PubMed
Year
2025
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
6
iCite
Relative citation ratio, by iCite
1.77, provisional
iCite
Revised in PubMed
2026-09-10
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Liao YYinsheng
2Mu GGuo
3Deng SShengfeng
4Lu BBin
5Zheng MMaoyaohttps://orcid.org/0009-0005-0048-1013

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Receptors, ImmunologicMajor topic
Membrane GlycoproteinsMajor topic
Neuroinflammatory DiseasesMajor topic
Translational Research, BiomedicalMajor topic
InflammationMajor topic
Humans
Animals
Microglia
Signal Transduction
Ligands

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References206

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
134,672,320Plasma sTREM2: a potential marker of cerebrovascular injury in neurodegenerative disorders.Brain2021https://conductscience.org/library/papers/34672320PubMed
237,917,301TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells.Mol Neurobiol2024https://conductscience.org/library/papers/37917301PubMed
332,466,767TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice.J Neuroinflammation2020https://conductscience.org/library/papers/32466767PubMed
432,514,138Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.Nat Neurosci2020https://conductscience.org/library/papers/32514138PubMed
533,065,553TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice.Aging (Albany NY)2020https://conductscience.org/library/papers/33065553PubMed
640,103,438TREM2 scFv-Engineering Escherichia coli Displaying Modulation of Macrophages to Boost Cancer Radio-Immunotherapy.Adv Mater2025https://conductscience.org/library/papers/40103438PubMed
738,865,485Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice.Sci Transl Med2024https://conductscience.org/library/papers/38865485PubMed
839,758,888Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke.Front Neurosci2024https://conductscience.org/library/papers/39758888PubMed
935,382,840CSF sTREM2 in neurological diseases: a two-sample Mendelian randomization study.J Neuroinflammation2022https://conductscience.org/library/papers/35382840PubMed
1026,949,937microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration.PLoS One2016https://conductscience.org/library/papers/26949937PubMed

1 to 10 of 206

See all 206 references

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.

PMIDTitleJournalYearIn PapersSource
42,742,907Pharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease.Inflammopharmacology2026https://conductscience.org/library/papers/42742907PubMed
42,317,585Peripheral biomarkers of neuronal damage in neuropsychiatric systemic lupus erythematosus (NPSLE).Front Cell Neurosci2026https://conductscience.org/library/papers/42317585PubMed
41,888,656TREM2 contributes to central sensitization through PI3K/Akt/mTOR-mediated autophagic dysfunction in a rat model of vestibular migraine.J Headache Pain2026https://conductscience.org/library/papers/41888656PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
TREM254,209PubTator's text mininghttps://conductscience.org/library/genes/54209

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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