Paper · 41570990

Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles.

Gong Q and 6 others. J Biol Chem, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles. Papers, record 41570990. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41570990

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles.; PubMed
Journal: J Biol Chem; PubMed
Year: 2026; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41570990/; PubMed
DOI: https://doi.org/10.1016/j.jbc.2026.111182; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12996777/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-08-13; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Gong Q	Qing
2	Zhao W	Weiwei
3	Wang T	Tiantian
4	Pan Y	Yuting
5	Cui C	Can
6	Qu Y	Yi
7	Zhou X	Xianglian

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Syndecan-4	Major topic
Syntenins	Major topic
Extracellular Vesicles	Major topic
Humans
Protein Binding
Animals
Diterpenes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References55

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	25,912,030	A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation.	Cell Mol Life Sci	2015	https://conductscience.org/library/papers/25912030	PubMed
2	37,977,120	The γ-secretase substrate proteome and its role in cell signaling regulation.	Mol Cell	2023	https://conductscience.org/library/papers/37977120	PubMed
3	33,246,160	MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity.	Osteoarthritis Cartilage	2021	https://conductscience.org/library/papers/33246160	PubMed
4	35,053,202	Site-Specific Proteasome Inhibitors.	Biomolecules	2021	https://conductscience.org/library/papers/35053202	PubMed
5	33,810,567	Syndecan-4 as a Pathogenesis Factor and Therapeutic Target in Cancer.	Biomolecules	2021	https://conductscience.org/library/papers/33810567	PubMed
6	29,976,761	Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments.	EMBO J	2018	https://conductscience.org/library/papers/29976761	PubMed
7	16,310,216	Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling.	J Mol Biol	2006	https://conductscience.org/library/papers/16310216	PubMed
8	23,374,111	Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.	FEBS J	2013	https://conductscience.org/library/papers/23374111	PubMed
9	25,941,170	Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics.	Trends Biochem Sci	2015	https://conductscience.org/library/papers/25941170	PubMed
10	33,990,545	Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma.	Cell Death Dis	2021	https://conductscience.org/library/papers/33990545	PubMed

1 to 10 of 55

See all 55 references

Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
SDC4	6,385	PubTator's text mining	https://conductscience.org/library/genes/6385	NCBI Gene
SDCBP	6,386	PubTator's text mining	https://conductscience.org/library/genes/6386	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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