Paper · 42225068

Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens.

Fenoglio S and 22 others. Cell Rep Methods, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens. Papers, record 42225068. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42225068

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens.; PubMed
Journal: Cell Rep Methods; PubMed
Year: 2026; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/42225068/; PubMed
DOI: https://doi.org/10.1016/j.crmeth.2026.101470; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13390110/; PubMed
The journal: https://conductscience.org/library/journal-index/9918227360606676; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-08-13; PubMed

Authors23

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Fenoglio S	Silvia
2	Yu Y	Yi
3	Tepper J	James
4	Grove L	Lauren
5	Bejnood A	Alborz
6	Meier SR	Samuel R
7	Choi AH	Ashley H
8	Wu HJ	Hsin-Jung
9	Devault A	Annabel
10	Liu S	Shangtao

1 to 10 of 23Source PubMed

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Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gene Library	Major topic
Clustered Regularly Interspaced Short Palindromic Repeats	Major topic
CRISPR-Cas Systems	Major topic
RNA, Guide, CRISPR-Cas Systems	Major topic
Humans
Animals
Cell Line, Tumor
Mice
Reproducibility of Results

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References52

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	27,653,681	Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.	Cell Rep	2016	https://conductscience.org/library/papers/27653681	PubMed
2	39,468,210	The present and future of the Cancer Dependency Map.	Nat Rev Cancer	2025	https://conductscience.org/library/papers/39468210	PubMed
3	40,223,602	Integration of Organoids With CRISPR Screens: A Narrative Review.	Biol Cell	2025	https://conductscience.org/library/papers/40223602	PubMed
4	40,035,511	Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.	J Med Chem	2025	https://conductscience.org/library/papers/40035511	PubMed
5	30,674,557	JACKS: joint analysis of CRISPR/Cas9 knockout screens.	Genome Res	2019	https://conductscience.org/library/papers/30674557	PubMed
6	37,436,979	An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate.	Sci Adv	2023	https://conductscience.org/library/papers/37436979	PubMed
7	23,550,210	Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.	Sci Signal	2013	https://conductscience.org/library/papers/23550210	PubMed
8	26,653,891	MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.	Genome Biol	2015	https://conductscience.org/library/papers/26653891	PubMed
9	39,227,068	FGA influences invasion and metastasis of hepatocellular carcinoma through the PI3K/AKT pathway.	Aging (Albany NY)	2024	https://conductscience.org/library/papers/39227068	PubMed
10	37,552,839	MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.	Cancer Discov	2023	https://conductscience.org/library/papers/37552839	PubMed

1 to 10 of 52

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
KMT2C	58,508	PubTator's text mining	https://conductscience.org/library/genes/58508	NCBI Gene
KMT2D	8,085	PubTator's text mining	https://conductscience.org/library/genes/8085	NCBI Gene
STAR	6,770	PubTator's text mining	https://conductscience.org/library/genes/6770	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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