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Paper · 37552839

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.

Engstrom LD and 31 others. Cancer Discov, 2023. Cited by 206 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer. Papers, record 37552839. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/37552839

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.
PubMed
Journal
Cancer Discov
PubMed
Year
2023
PubMed
Publication types
Clinical Trial, Phase II, Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
206
iCite
Relative citation ratio, by iCite
16.1
iCite
Revised in PubMed
2024-01-10
PubMed

Authors32

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Engstrom LDLars Dhttps://orcid.org/0000-0001-8196-9427
2Aranda RRuthhttps://orcid.org/0009-0008-1754-7367
3Waters LLaurahttps://orcid.org/0009-0009-0127-1631
4Moya KKrystalhttps://orcid.org/0009-0008-6717-8934
5Bowcut VVickiehttps://orcid.org/0000-0002-4934-9225
6Vegar LLaurahttps://orcid.org/0009-0002-9860-746X
7Trinh DDavidhttps://orcid.org/0009-0000-7534-1430
8Hebbert AAllanhttps://orcid.org/0009-0005-0766-2386
9Smith CRChristopher Rhttps://orcid.org/0000-0002-6553-2791
10Kulyk SSvitlanahttps://orcid.org/0000-0003-0346-3441

1 to 10 of 32Source PubMed

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Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carcinoma, Non-Small-Cell LungMajor topic
Lung NeoplasmsMajor topic
Humans
Cell Line, Tumor
Synthetic Lethal Mutations
Enzyme Inhibitors
Protein-Arginine N-Methyltransferases

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
P30 CA008748NCI NIH HHSUnited StatesP30CA008748PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in37,909,092Early Clinical Success of MTA-Cooperative PRMT5 Inhibitors for the Treatment of CDKN2A/MTAP-Deleted Cancers.https://conductscience.org/library/papers/37909092

Source PubMed

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
119,097,774New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).Eur J Cancer2009https://conductscience.org/library/papers/19097774PubMed
228,546,227Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials.Clin Cancer Res2017https://conductscience.org/library/papers/28546227PubMed
331,712,683Synthetic lethality as an engine for cancer drug target discovery.Nat Rev Drug Discov2020https://conductscience.org/library/papers/31712683PubMed
428,061,334Arginine Methylation: The Coming of Age.Mol Cell2017https://conductscience.org/library/papers/28061334PubMed
525,605,792limma powers differential expression analyses for RNA-sequencing and microarray studies.Nucleic Acids Res2015https://conductscience.org/library/papers/25605792PubMed
627,068,473MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.Cell Rep2016https://conductscience.org/library/papers/27068473PubMed
726,912,360MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Science2016https://conductscience.org/library/papers/26912360PubMed
829,946,150Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.Sci Rep2018https://conductscience.org/library/papers/29946150PubMed
928,396,521Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly.Genome Res2017https://conductscience.org/library/papers/28396521PubMed
1016,199,517Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/16199517PubMed

1 to 10 of 30

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Cited by137

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 206 citations.

PMIDTitleJournalYearIn PapersSource
42,963,543KRAS in pancreatic cancer: from molecular biology to transformative therapeutics.J Hematol Oncol2026https://conductscience.org/library/papers/42963543PubMed
42,938,892MTAP Loss and Pleural Mesothelioma (PM): Current Treatment Strategies and Emerging Therapeutic Approaches.Cancers (Basel)2026https://conductscience.org/library/papers/42938892PubMed
42,885,740Case Report WIN-MTB-2024001 - WIN International Molecular Tumor Board: A 55-year-old male with glioblastoma exhibiting amplifications in MDM2 and EGFR.Oncotarget2026https://conductscience.org/library/papers/42885740PubMed
42,882,485The Crosstalk Between Metabolic Reprogramming and Histone Methylation in Tumor Immunity and Immunotherapy.Cells2026https://conductscience.org/library/papers/42882485PubMed
42,792,878Alternative RNA Splicing in Cancer: Molecular Mechanisms, Functional Consequences, Biomarkers and Therapeutic Opportunities.Genes (Basel)2026https://conductscience.org/library/papers/42792878PubMed
42,764,959Deconvoluting the multi-faceted roles of alternative splicing events in cancer: From underlying mechanisms to innovative therapeutics.Acta Pharm Sin B2026https://conductscience.org/library/papers/42764959PubMed
42,742,841Protein arginine methyltransferases as metabolic regulators: many roles beyond cancer.Sci China Life Sci2026https://conductscience.org/library/papers/42742841PubMed
42,737,808Patient-Derived Organoid Models and Precision HIPEC in Diffuse Malignant Peritoneal Mesothelioma: Modeling Heterogeneity to Address Recurrence.Int J Mol Sci2026https://conductscience.org/library/papers/42737808PubMed
42,736,388Targeting the PRMT5-CBX8 axis overcomes dual barriers of CD8⁺ T cell exclusion and tumor stemness for sensitizing TNBC to anti-PD-1 therapy.Oncogene2026https://conductscience.org/library/papers/42736388PubMed
42,676,823Multi-omics integration in malignant pleural mesothelioma: from molecular evolution and immune ecosystems to precision therapy.Front Oncol2026https://conductscience.org/library/papers/42676823PubMed

1 to 10 of 137

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Genes44

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ALK238PubTator's text mininghttps://conductscience.org/library/genes/238NCBI Gene
ANPEP290PubTator's text mininghttps://conductscience.org/library/genes/290NCBI Gene
ANXA5308PubTator's text mininghttps://conductscience.org/library/genes/308NCBI Gene
ARID1A8,289PubTator's text mininghttps://conductscience.org/library/genes/8289NCBI Gene
BAP18,314PubTator's text mininghttps://conductscience.org/library/genes/8314NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
CD34947PubTator's text mininghttps://conductscience.org/library/genes/947NCBI Gene
CDK1983PubTator's text mininghttps://conductscience.org/library/genes/983NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
CDKN2B1,030PubTator's text mininghttps://conductscience.org/library/genes/1030NCBI Gene

1 to 10 of 44

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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