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Paper · 42783

Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle.

Barchi RL and 1 other. J Physiol, 1979. Cited by 91 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle. Papers, record 42783. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42783

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle.
PubMed
Journal
J Physiol
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
91
iCite
Relative citation ratio, by iCite
2.64
iCite
Revised in PubMed
2019-05-09
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Barchi RLR L
2Weigele JBJ B

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Ion ChannelsMajor topic
SarcolemmaMajor topic
SaxitoxinMajor topic
SodiumMajor topic
Animals
Binding Sites
Binding, Competitive
Hydrogen-Ion Concentration
Kinetics
Muscle Denervation
Muscles
Osmolar Concentration
Rats
Temperature

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References26

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,080,198Tetrodotoxin binding to normal depolarized frog muscle and the conductance of a single sodium channel.J Physiol1975https://conductscience.org/library/papers/1080198PubMed
21,083,895Density and distribution of tetrodotoxin receptors in normal and detubulated frog sartorius muscle.J Gen Physiol1976https://conductscience.org/library/papers/1083895PubMed
31,087,646The binding of labelled saxitoxin to normal and denervated muscle [proceedings].J Physiol1976https://conductscience.org/library/papers/1087646PubMed
5138,140Isolation and characterization of muscle membranes using surface-specific labels.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/138140PubMed
6216,403Muscle surface membranes: preparative methods affect apparent chemical properties and neurotoxin binding.Biochim Biophys Acta1979https://conductscience.org/library/papers/216403PubMed
722,807Characterization of exchange-labeled saxitoxin and the origin of linear uptake by excitable tissue.Mol Pharmacol1977https://conductscience.org/library/papers/22807PubMed
8238,231Binding of tetrodotoxin and saxitoxin to sodium channels.Philos Trans R Soc Lond B Biol Sci1975https://conductscience.org/library/papers/238231PubMed
928,248Analysis of saxitoxin binding in isolated rat synaptosomes using a rapid filtration assay.FEBS Lett1978https://conductscience.org/library/papers/28248PubMed
1031,301Saxitoxin binding to the mammalian sodium channel. Competition by monovalent and divalent cations.FEBS Lett1978https://conductscience.org/library/papers/31301PubMed
113,213Properties of the tetrodotoxin binding component in plasma membranes isolated from Electrophorus electricus.Biochemistry1976https://conductscience.org/library/papers/3213PubMed

1 to 10 of 26

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Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 91 citations.

PMIDTitleJournalYearIn PapersSource
40,710,502Saxitoxin: A Comprehensive Review of Its History, Structure, Toxicology, Biosynthesis, Detection, and Preventive Implications.Mar Drugs2025https://conductscience.org/library/papers/40710502PubMed
23,008,436Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.J Gen Physiol2012https://conductscience.org/library/papers/23008436PubMed
20,631,873Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe.Mar Drugs2010https://conductscience.org/library/papers/20631873PubMed
9,826,589Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.Biophys J1998https://conductscience.org/library/papers/9826589PubMed
8,384,241Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction.J Gen Physiol1993https://conductscience.org/library/papers/8384241PubMed
8,179,845Structure, function and expression of voltage-dependent sodium channels.Mol Neurobiol1993https://conductscience.org/library/papers/8179845PubMed
8,011,896Permeation of Na+ through open and Zn(2+)-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions in a multi-ion channel.Biophys J1994https://conductscience.org/library/papers/8011896PubMed
7,696,471Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels.Biophys J1994https://conductscience.org/library/papers/7696471PubMed
6,610,169Denervated frog skeletal muscle. Some electrical and mechanical properties.Pflugers Arch1984https://conductscience.org/library/papers/6610169PubMed
6,335,243Effect of various cations and anions on the action of tetrodotoxin and saxitoxin on frog myelinated nerve fibers.Pflugers Arch1984https://conductscience.org/library/papers/6335243PubMed

1 to 10 of 27

See all 27 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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