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Paper · 42826199

Tumor cell-intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer.

Fröse J and 11 others. Sci Adv, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Tumor cell-intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer. Papers, record 42826199. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42826199

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Tumor cell-intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer.
Journal
Sci Adv
Year
2026
Publication types
Journal Article
Revised in PubMed
2026-10-08

Source PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Fröse JJuliahttps://orcid.org/0000-0002-8179-1777
2Chen EEvelynhttps://orcid.org/0000-0003-1102-6997
3Whittaker CACharles Ahttps://orcid.org/0000-0002-2400-0094
4Leclerc PPaulhttps://orcid.org/0009-0007-6392-6512
5Doherty SSeanhttps://orcid.org/0009-0007-2096-8026
6Langenbucher AAdam
7Shao JJasminehttps://orcid.org/0009-0004-6831-9832
8Hellinger RDRiley Dhttps://orcid.org/0000-0001-6303-3641
9Goulet DDaniel
10Tammela TTuomashttps://orcid.org/0000-0003-3675-6961

1 to 10 of 12Source PubMed

See all 12 authors

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Pancreatic NeoplasmsMajor topic
Immunotherapy, AdoptiveMajor topic
Carcinoma, Pancreatic DuctalMajor topic
Receptors, Chimeric AntigenMajor topic
Stress, PhysiologicalMajor topic
Humans
Animals
Mice
Cell Line, Tumor
Kelch-Like ECH-Associated Protein 1
NF-E2-Related Factor 2
Xenograft Model Antitumor Assays

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 CA014051NCI NIH HHSUnited StatesP30CA014051PubMedNIH RePORTER
R01 CA290400NCI NIH HHSUnited StatesR01CA290400PubMedNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Update of40,766,461In vivo screening reveals cell-intrinsic mediators of solid tumor resistance to CAR T cell-therapy.https://conductscience.org/library/papers/40766461

Source PubMed

References87

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
131,540,286Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions.Int J Mol Sci2019https://conductscience.org/library/papers/31540286PubMed
231,570,880Tumour-intrinsic resistance to immune checkpoint blockade.Nat Rev Immunol2020https://conductscience.org/library/papers/31570880PubMed
339,845,944Pseudoprogression in CAR-T cell therapy for solid tumor: Case report.Front Immunol2024https://conductscience.org/library/papers/39845944PubMed
439,112,706Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.Nature2024https://conductscience.org/library/papers/39112706PubMed
536,917,948The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.Cancer Cell2023https://conductscience.org/library/papers/36917948PubMed
632,467,592Immune checkpoint signaling and cancer immunotherapy.Cell Res2020https://conductscience.org/library/papers/32467592PubMed
726,516,065Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.Cancer Discov2015https://conductscience.org/library/papers/26516065PubMed
840,764,107Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1, SMARCA4, and PTEN mutations.J Immunother Cancer2025https://conductscience.org/library/papers/40764107PubMed
937,248,395Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.Nat Cancer2023https://conductscience.org/library/papers/37248395PubMed
1028,967,920Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.Nat Med2017https://conductscience.org/library/papers/28967920PubMed

1 to 10 of 87

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first.

None in this release.

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
KEAP19,817PubTator's text mininghttps://conductscience.org/library/genes/9817NCBI Gene
NFE2L24,780PubTator's text mininghttps://conductscience.org/library/genes/4780NCBI Gene
SLC33A19,197PubTator's text mininghttps://conductscience.org/library/genes/9197NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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