Paper · 53729

Functional subdivision of islets of Langerhans and possible role of D cells.

Orci L and 1 other. Lancet, 1975. Cited by 417 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Functional subdivision of islets of Langerhans and possible role of D cells. Papers, record 53729. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/53729

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Functional subdivision of islets of Langerhans and possible role of D cells.; PubMed
Journal: Lancet; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/53729/; PubMed
DOI: https://doi.org/10.1016/s0140-6736(75)92078-4; PubMed
The journal: https://conductscience.org/library/journal-index/2985213R; PubMed
Citations, by iCite: 417; iCite
Relative citation ratio, by iCite: 11.1; iCite
Revised in PubMed: 2019-06-10; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Orci L	L
2	Unger RH	R H

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Islets of Langerhans	Major topic
Somatostatin	Major topic
Animals
Glucagon
Humans
Insulin
Insulin Antagonists
Insulin Secretion

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by134

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 417 citations.

PMID	Title	Journal	Year	In Papers	Source
42,734,243	Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia.	Ann N Y Acad Sci	2026	https://conductscience.org/library/papers/42734243	PubMed
42,627,374	Pancreatic islets: new discoveries for innovative treatments of diabetes?	Diabetologia	2026	https://conductscience.org/library/papers/42627374	PubMed
42,451,182	Systematic Expression and Localization Profiling of Piezo2 in Rodent Pancreatic Islets.	Nutrients	2026	https://conductscience.org/library/papers/42451182	PubMed
36,834,860	Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes.	Int J Mol Sci	2023	https://conductscience.org/library/papers/36834860	PubMed
35,258,417	Determinants and dynamics of pancreatic islet architecture.	Islets	2022	https://conductscience.org/library/papers/35258417	PubMed
35,165,817	Shifting Paradigms in the Pathophysiology and Treatment of Carcinoid Crisis.	Ann Surg Oncol	2022	https://conductscience.org/library/papers/35165817	PubMed
34,580,120	Pancreatic β-Cell Development and Regeneration.	Cold Spring Harb Perspect Biol	2022	https://conductscience.org/library/papers/34580120	PubMed
34,502,413	The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.	Int J Mol Sci	2021	https://conductscience.org/library/papers/34502413	PubMed
34,231,467	Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells.	Elife	2021	https://conductscience.org/library/papers/34231467	PubMed
34,209,449	Pancreatic β Cells Inhibit Glucagon Secretion from α Cells: An In Vitro Demonstration of α-β Cell Interaction.	Nutrients	2021	https://conductscience.org/library/papers/34209449	PubMed

1 to 10 of 134

See all 134 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
GCG	2,641	PubTator's text mining	https://conductscience.org/library/genes/2641	NCBI Gene
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
SST	6,750	PubTator's text mining	https://conductscience.org/library/genes/6750	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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