Paper · 6180296

Control of dihydrofolate reductase messenger ribonucleic acid production.

Leys EJ and 1 other. Mol Cell Biol, 1981. Cited by 85 papers, by iCite.

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ConductScience Library. Control of dihydrofolate reductase messenger ribonucleic acid production. Papers, record 6180296. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6180296

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Control of dihydrofolate reductase messenger ribonucleic acid production.; PubMed
Journal: Mol Cell Biol; PubMed
Year: 1981; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6180296/; PubMed
DOI: https://doi.org/10.1128/mcb.1.11.961-971.1981; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC369718/; PubMed
The journal: https://conductscience.org/library/journal-index/8109087; PubMed
Citations, by iCite: 85; iCite
Relative citation ratio, by iCite: 1.78; iCite
Revised in PubMed: 2021-05-26; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Leys EJ	E J
2	Kellems RE	R E

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
RNA, Messenger	Major topic
Tetrahydrofolate Dehydrogenase	Major topic
Animals
Cell Division
Cell Nucleus
Cells, Cultured
Cytoplasm
DNA, Recombinant
Drug Resistance
Methotrexate
Mice
Nucleic Acid Hybridization
Poly A
RNA
Sarcoma 180

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
CA24618	NCI NIH HHS	United States	R01CA024618	PubMed and NIH	NIH RePORTER
RR-05425	NCRR NIH HHS	United States		PubMed	PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	360,074	Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.	Nature	1978	https://conductscience.org/library/papers/360074	PubMed
2	6,267,077	The effect of polyoma virus, serum factors, and dibutyryl cyclic AMP on dihydrofolate reductase synthesis, and the entry of quiescent cells into S phase.	J Cell Physiol	1981	https://conductscience.org/library/papers/6267077	PubMed
3	13,710,631	Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.	J Biol Chem	1961	https://conductscience.org/library/papers/13710631	PubMed
4	4,288,549	Induction of dihydrofolate reductase activity by SV40 and polyoma virus.	Cancer Res	1966	https://conductscience.org/library/papers/4288549	PubMed
5	4,504,350	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	Proc Natl Acad Sci U S A	1972	https://conductscience.org/library/papers/4504350	PubMed
6	4,526,211	Rapid inactivation of ovalbumin messenger ribonucleic acid after acute withdrawal of estrogen.	Proc Natl Acad Sci U S A	1974	https://conductscience.org/library/papers/4526211	PubMed
7	1,090,375	Transcription in polytene chromosomes.	Cell	1975	https://conductscience.org/library/papers/1090375	PubMed
8	944,697	Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.	J Biol Chem	1976	https://conductscience.org/library/papers/944697	PubMed
9	954,102	Biosynthesis and stability of globin mRNA in cultured erythroleukemic Friend cells.	Cell	1976	https://conductscience.org/library/papers/954102	PubMed
10	62,753	Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.	J Biol Chem	1976	https://conductscience.org/library/papers/62753	PubMed

1 to 10 of 33

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Cited by33

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 85 citations.

PMID	Title	Journal	Year	In Papers	Source
14,582,196	Genetic test for involvement of intervening sequences in transport of nuclear RNA.	Mol Cell Biol	1982	https://conductscience.org/library/papers/14582196	PubMed
6,865,943	Control of cellular gene expression during adenovirus infection: induction and shut-off of dihydrofolate reductase gene expression by adenovirus type 2.	Mol Cell Biol	1983	https://conductscience.org/library/papers/6865943	PubMed
6,736,126	Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus.	J Cell Biol	1984	https://conductscience.org/library/papers/6736126	PubMed
6,646,125	Delayed processing of dihydrofolate reductase heterogeneous nuclear RNA in amino acid-starved mouse fibroblasts.	Mol Cell Biol	1983	https://conductscience.org/library/papers/6646125	PubMed
6,493,233	tk Enzyme expression in differentiating muscle cells is regulated through an internal segment of the cellular tk gene.	Mol Cell Biol	1984	https://conductscience.org/library/papers/6493233	PubMed
6,285,377	Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6285377	PubMed
6,227,808	Isolation and preliminary characterization of the Chinese hamster thymidine kinase gene.	Mol Cell Biol	1983	https://conductscience.org/library/papers/6227808	PubMed
6,209,555	Inhibition of protein synthesis stabilizes histone mRNA.	Mol Cell Biol	1984	https://conductscience.org/library/papers/6209555	PubMed
6,199,739	Post-transcriptional regulation of the chicken thymidine kinase gene.	Nucleic Acids Res	1984	https://conductscience.org/library/papers/6199739	PubMed
6,186,903	Genetic analysis of alpha-fetoprotein synthesis in mice.	Mol Cell Biol	1982	https://conductscience.org/library/papers/6186903	PubMed

1 to 10 of 33

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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